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排序方式: 共有253条查询结果,搜索用时 31 毫秒
121.
K. Sakuraba Y. Tsuruda T. Hanada J.-C. Liou Y. Akahoshi 《International Journal of Impact Engineering》2008
This paper summarizes two new satellite impact tests conducted in order to investigate on the outcome of low- and hypervelocity impacts on two identical target satellites. The first experiment was performed at a low velocity of 1.5 km/s using a 40-g aluminum alloy sphere, whereas the second experiment was performed at a hypervelocity of 4.4 km/s using a 4-g aluminum alloy sphere, by a two-stage light gas gun. To date, approximately 1500 fragments from each impact test have been collected for detailed analysis. Each piece was analyzed based on the method used in the NASA standard breakup model 2000 revision. The detailed analysis will conclude (1) the similarity in mass distribution of fragments between low- and hypervelocity impacts encourages the development of a general-purpose mass-based distribution model applicable for a wide impact velocity range, and (2) the difference in area-to-mass ratio distribution between the impact experiments and the NASA standard breakup model suggests to describe the area-to-mass ratio by a bi-normal distribution. 相似文献
122.
T Sato T Hanada M Arioka TI Morita H Koshino M Uramoto M Yamasaki K Kitamoto 《Canadian Metallurgical Quarterly》1998,51(11):1047-1050
A trend can be observed for multinational research-based drug companies shifting their resources away from Germany (and partly also from Europe) and expanding their preclinical and clinical drug research and development programmes and organizations in the USA. The main reasons, which are presently under discussion in Germany, are the image and public acceptance of clinical drug research, professionalism of clinical studies (i.e. availability of an adequate infrastructure), the process of ethics committees votes, the citation impact of publications, the legal obstacles, the implementation of Good Clinical Practice (GCP), the regulatory and institutional situation and the political environment. These problems have been recognised and appraised recently by the pharmaceutical industry, universities, scientific associations, and governmental institutions. Prerequisites to improve the basic conditions of clinical research in Germany to make it internationally competitive are proposed in this paper. 相似文献
123.
K Yamamoto R Hanada A Kikuchi M Ichikawa T Aihara E Oguma T Moritani Y Shimanuki M Tanimura Y Hayashi 《Canadian Metallurgical Quarterly》1998,16(4):1265-1269
PURPOSE: A retroperitoneal access is commonly used for open urological procedures. Since the introduction of the balloon dissecting technique by Gaur this anatomical route has also been used for laparoscopic surgery. We present our experience with retroperitoneoscopy in 200 cases. MATERIALS AND METHODS: From December 1992 to October 1997 a total of 200 retroperitoneoscopic procedures were performed in 197 patients 4 to 82 years old, comprising 78 nephrectomies, 50 renal cyst resections, 14 nephropexies, 11 ureterolyses, 8 retroperitoneal lymph node dissections, 8 renal biopsies, 6 adrenalectomies, 6 heminephrectomies, 6 pyeloplasties, 5 ureterolithotomies, 6 ureterocutaneostomies and 2 others. Of the patients 38 (19%) and 22 (11%) had undergone previous abdominal surgery, and kidney and ureter operations, respectively. Dissection of the retroperitoneal space was enabled by the use of a balloon catheter in 14, balloon trocar system in 93 and finger dissection technique in 93 cases. RESULTS: We classified 76 procedures (38%) as simple (renal biopsy, renal cyst resections, ureterocutaneostomy), 102 (51%) as difficult (adrenalectomy, nephrectomy, nephropexy) and 22 (11%) as very difficult (pyeloplasty, heminephrectomy, lymphadenectomy). There was a significant learning curve during the first 50 cases reflected by longer operating time, and higher complication, conversion to open surgery and open reintervention rates (14, 10 and 6%, respectively). In addition to the learning curve, mean operating time depended on the difficulty of the procedure, averaging 45 to 100 minutes for a simple, 95 to 185 for a difficult and 185 to 240 for a very difficult retroperitoneoscopy. In the last 50 cases the complication, conversion and reintervention rates (2, 4 and 2%, respectively) were acceptable for routine clinical application. CONCLUSIONS: After experience with more than 200 cases of retroperitoneoscopy the access technique has been significantly simplified. The procedure is standardized, safe and reproducible. 相似文献
124.
T Kameyama F Ando F Okamoto M Hanada N Sasahashi 《Canadian Metallurgical Quarterly》1998,66(6):2108-2110
Aortomitral common annular involvement, which is not uncommon in infective endocarditis, necessitates deliberate surgical procedures. To repair fibrous skeleton abscess accompanied with annuloaortic ectasia, we used a brimmed valved conduit. Tension-free reconstruction of the aortic root and aortomitral common annulus was easily performed with this method. 相似文献
125.
Hanada M. Ikeda Y. Kamada M. Kikuchi K. Komata M. Mogaki K. Umeda N. Usui K. Grisham L.R. Kobayashi S. 《Dielectrics and Electrical Insulation, IEEE Transactions on》2007,14(3):572-576
Voltage holding capability in a 500 keV electrostatic accelerator with large FRP insulators was examined without the beam acceleration. When high voltage was applied, the light with a broad peak at a wavelength of 420 nm was mostly emitted inside the accelerator even though breakdown did not occur. The voltage holding capability has a strong correlation with the light intensity. Stable voltage holding was realized under the conditions in which light emission was well suppressed. 相似文献
126.
127.
Phase field and room-temperature mechanical properties of the C15 laves phase in the Zr-Ta-Cr alloy system 总被引:1,自引:0,他引:1
T. Ohta Y. Kaneno H. Inoue T. Takasugi S. Hanada 《Metallurgical and Materials Transactions A》2005,36(3):583-590
The phase field of the C15 Laves phase in the Zr-Ta-Cr alloy system at 1273 K exhibited a continuous solid solution along
the ZrCr2-TaCr2 pseudobinary line and also a broad off-stoichiometric range on the (Zr,Ta)-rich side. The defect structures in the C15 Laves
phase were evaluated by lattice parameter and density measurements. The room-temperature fracture toughness was assessed by
Vickers indentation testing. Alloying, off-stoichiometry, and the related defect structures were shown to be beneficial for
improving the room-temperature deformability of the C15 Laves phase in the Zr-Ta-Cr alloy system. The results are discussed
in terms of the constituent atomic sizes on the most closely packed planes in the C15 Laves phase where shear deformation
takes place.
This article is based on a presentation made in the symposium entitled “Beyond Nickel-Base Superalloys,” which took place
March 14–18, 2004, at the TMS Spring meeting in Charlotte, NC, under the auspices of the SMD-Corrosion and Environmental Effects
Committee, the SMD-High Temperature Alloys Committee, the SMD-Mechanical Behavior of Materials Committee, and the SMD-Refractory
Metals Committee. 相似文献
128.
K Hachisuka S Saeki H Ogata K Nakahara Y Hanada 《Canadian Metallurgical Quarterly》1998,20(4):297-306
Detection of nucleic acid sequence at the ultrastructural level has allowed us to better understand the expression of genes in some fields of application in cell biology. In situ hybridization at the ultrastructural level can be carried out using three different methods: on vibratome sections before embedding in epoxy resin, on ultrathin frozen section, or on ultrathin section of tissue embedded in hydrophilic resin such as Lowicryl. Before starting the detection of nucleic acid sequences at the electron microscope level, the experimenter has to choose various parameters; the type of tissue fixation, the probe and its label, and the in situ hybridization method, depending on the sensitivity, the resolution and the ultrastructural preservation required. This review of technical aspects, by describing the different methods of ultrastructural in situ hybridization, will help the experimenter to optimize each step of the hybridization procedure. 相似文献
129.
130.
T Yamaoka M Hanada S Ichii S Morisada T Noguchi Y Yanagi 《Canadian Metallurgical Quarterly》1998,89(10):1067-1073
Amrubicin, a completely synthetic 9-aminoanthracycline derivative, was previously shown to have potent antitumor activities against various human tumor xenografts. In this study, the in vitro activities of amrubicin and its major metabolite, amrubicinol, were examined using 17 human tumor cell lines. Amrubicinol was 5 to 54 times more potent than amrubicin, and as potent as doxorubicin, in inhibiting the growth of the cells following 3-day continuous drug exposure. Amrubicinol closely resembled doxorubicin in its profile of activities on the 17 human tumor cell lines. Cells were incubated with the drugs for 1 h, and the intracellular drug concentration and cell growth inhibition after 3 days were determined. Amrubicinol attained similar intracellular concentrations at lower medium concentrations compared to amrubicin, and the intracellular concentration of amrubicinol necessary to produce 50% cell growth inhibition was 3 to 8 times lower than that of amrubicin in 4 cell lines tested. Amrubicinol has a higher activity level inside the cells than does amrubicin. When cells were incubated with amrubicin for 5 h, a substantial amount of amrubicinol, more than 9% of that of amrubicin, was found in cells in 4 of the 8 cell lines tested. Amrubicinol may contribute to the in vitro growth-inhibitory effect of amrubicin on these cells. The results suggest that amrubicinol plays an important role in the in vivo antitumor effect of amrubicin as an active metabolite. 相似文献