The Identification and Influence of Social Roles in a Social Media Product Community

This research focuses on the identification of social roles and an investigation of their influence in online context. Relying on a systemic approach for role conceptualization, we investigate member's activity, shared content and position in the network within a consumer to consumer social media‐based community (SMC) around a product. This investigation led to the identification of ten core roles, based on three key elements: object of interest (product, practice, and community), main contribution type (sharing information and seeking information), individual orientation (factual, emotional). We propose an explanation about how these roles, through their positioning, participate in the community dynamics and how they contribute to the creation and diffusion of cookery as a social practice, shaping the periphery around this practice.     

Gene subset selection using an iterative approach based on genetic algorithms

Microarray data are expected to be useful for cancer classification. However, the process of gene selection for the classification contains a major problem due to properties of the data such as the small number of samples compared with the huge number of genes (higher-dimensional data), irrelevant genes, and noisy data. Hence, this article aims to select a near-optimal (small) subset of informative genes that is most relevant for the cancer classification. To achieve this aim, an iterative approach based on genetic algorithms has been proposed. Experimental results show that the performance of the proposed approach is superior to other previous related work, as well as to four methods tried in this work. In addition, a list of informative genes in the best gene subsets is also presented for biological usage.     

Hybrid Paper–Plastic Microchip for Flexible and High‐Performance Point‐of‐Care Diagnostics

A low‐cost and easy‐to‐fabricate microchip remains a key challenge for the development of true point‐of‐care (POC) diagnostics. Cellulose paper and plastic are thin, light, flexible, and abundant raw materials, which make them excellent substrates for mass production of POC devices. Herein, a hybrid paper–plastic microchip (PPMC) is developed, which can be used for both single and multiplexed detection of different targets, providing flexibility in the design and fabrication of the microchip. The developed PPMC with printed electronics is evaluated for sensitive and reliable detection of a broad range of targets, such as liver and colon cancer protein biomarkers, intact Zika virus, and human papillomavirus nucleic acid amplicons. The presented approach allows a highly specific detection of the tested targets with detection limits as low as 10² ng mL^?1 for protein biomarkers, 10³ particle per milliliter for virus particles, and 10² copies per microliter for a target nucleic acid. This approach can potentially be considered for the development of inexpensive and stable POC microchip diagnostics and is suitable for the detection of a wide range of microbial infections and cancer biomarkers.     

Horizontal bracing to enhance progressive collapse resistance of steel moment frames

In this paper, the effect of horizontal bracing on enhancing the resistance of steel moment frames against progressive collapse is investigated. Previously designed 6 bay by 3 bay 18‐story steel frame prototype building with 6 m bay span (namely, unbraced frame), which was susceptible to progressive collapse, is retrofitted by four types of horizontal bracing systems on the perimeter of the topmost story and analyzed using 3D nonlinear dynamic method. Six different cross‐sections for each bracing system type are considered, and the capacity curves for each model are obtained. Three column removal circumstances, namely, Edge Short Column, First Edge Long Column, and Edge Long Column are considered in this paper. The results imply that horizontal bracing would increase the resistance of moment frames against progressive collapse. However, one of the bracing types in which axial compressive force is created in braces is not appropriate for retrofitting.     

An Overview on SARS‑CoV‑2(COVID‑19)and Other Human Coronaviruses and Their Detection Capability via Amplification Assay,Chemical Sensing,Biosensing,Immunosensing,and Clinical Assays

A novel coronavirus of zoonotic origin(SARSCoV-2)has recently been recognized in patients with acute respiratory disease.COVID-19 causative agent is structurally and genetically similar to SARS and bat SARS-like coronaviruses.The drastic increase in the number of coronavirus and its genome sequence have given us an unprecedented opportunity to perform bioinformatics and genomics analysis on this class of viruses.Clinical tests like PCR and ELISA for rapid detection of this virus are urgently needed for early identification of infected patients.However,these techniques are expensive and not readily available for point-of-care(POC)applications.Currently,lack of any rapid,available,and reliable POC detection method gives rise to the progression of COVID-19 as a horrible global problem.To solve the negative features of clinical investigation,we provide a brief introduction of the general features of coronaviruses and describe various amplification assays,sensing,biosensing,immunosensing,and aptasensing for the determination of various groups of coronaviruses applied as a template for the detection of SARS-CoV-2.All sensing and biosensing techniques developed for the determination of various classes of coronaviruses are useful to recognize the newly immerged coronavirus,i.e.,SARS-CoV-2.Also,the introduction of sensing and biosensing methods sheds light on the way of designing a proper screening system to detect the virus at the early stage of infection to tranquilize the speed and vastity of spreading.Among other approaches investigated among molecular approaches and PCR or recognition of viral diseases,LAMP-based methods and LFAs are of great importance for their numerous benefits,which can be helpful to design a universal platform for detection of future emerging pathogenic viruses.     

Antioxidant activity and phenolic content of phenolic rich fractions obtained from black cumin (Nigella sativa) seedcake

The antioxidant activities of crude methanolic extract (CME) and its fractions using ethyl acetate (EAF), hexane (HF) and water (WF) of black cumin seedcake were investigated. DPPH radical scavenging activity, β-carotene–linoleate bleaching, and inhibition of corn oil oxidation were used to evaluate the antioxidant capacity. The total phenolics were found to be 78.8, 27.8, 32.1 and 12.1 mg gallic acid equivalents (GAE)/g in EAF, CME, WF and HF, respectively. The CME and EAF exhibited the highest DPPH followed by WF and HF. The extract/fractions showed high effect on reducing the oxidation of β-carotene. The effect of extract/fractions on the oxidative stability of corn oil at 70 °C was tested in the dark and compared with butylated hydroxyanisole (BHA). The oil peroxide and anisidine values were generally lower with addition of PRFs in comparison to a control. The predominant phenolic compounds identified by HPLC–DAD in CME and WF of black cumin seedcake were hydroxybenzoic, syringic and p-cumaric acids.     

In vitro antioxidant and in vivo xanthine oxidase inhibitory activities of Pandanus amaryllifolius in potassium oxonate‐induced hyperuricemic rats

Xanthine oxidase (XO) plays an important role in the regulation of uric acid and prevents it from being overproduced as in hyperuricemia disease. The combined effects of antioxidant and xanthine oxidase inhibitor would become a promising approach for hyperuricemia treatment. In this research, the antioxidant and xanthine oxidase inhibitory activities of Pandanus amaryllifolius leaf were evaluated. The leaf water extract (PA‐W) showed highest total phenols, and petroleum ether extract (PA‐PE) showed highest total flavonoids contents. The antioxidant activity of DPPH, metal chelating and hydrogen peroxide was highest in PA‐W extract. The treatment of PA‐W extract at 1000 mg kg^?1 body weight in potassium oxonate‐induced hyperuricemic rats showed significant (P < 0.001) decrease in serum uric acid level by 85% and XO activity by 64%, respectively, as compared to the hyperuricemic rats. In conclusion, the P. amaryllifolius possess the dual effect of antioxidant and XO inhibition as potential therapeutic agents in the hyperuricemia treatment.     

Simultaneous Determination of Sodium, Potassium, Manganese and Bromine in Tea by Standard Addition Neutron Activation Analysis

Standard addition method was applied for neutron activation analysis of tea leaves. Four brands of tea leaves were analyzed for its Na, K, Mn, and Br contents by this method. The Na, K, Mn, and Br concentrations were found to be in the 90–120 μg/g, 1.8–2.1% w/w, 150–500 and 3–7 μg/g ranges, respectively. The extraction efficiency of these elements, during the infusion, was calculated by analysis of tea leaves before and after the infusion process. It was observed that about 90% of the Na, K, and Br elements were extracted to water during the infusion process. The drinking tea is a rich source of Mn (despite of an extraction efficiency of 50% for this element).     

LAI based trees selection for mid latitude urban developments: A microclimatic study in Cairo, Egypt

To study the leaf area index, LAI, based thermal performance in distinguishing trees for Cairo's urban developments, ENVI-met plants database was used as platform for a foliage modeling parameter, the leaf area density, LAD. Two Egyptian trees; Ficus elastica, and Peltophorum pterocarpum were simulated in 2 urban sites with one having no trees, whilst the second is having Ficus nitida trees. Trees LAD values were calculated using flat leaves' trees LAI definition to produce maximum ground solid shadow at peak time. An empirical value of 1 for LAI is applied to numerically introduce LAD values for ENVI-met.Basically, different meteorological records showed improvements for pedestrian comfort and ambient microclimate of the building using F. elastica. About 40–50% interception of direct radiation, reductions in surfaces' fluxes around trees and in radiant temperature T_mrt in comparison to base cases gave preferability to F. elastica. The lack of soil water prevented evapotranspiration to take place effectively and the reduced wind speeds concluded negligible air temperature differences from both base cases except slightly appeared with the F. elastica. Results show that a flat leaves tree if does not validate LAI of 1, the ground shading would not fulfill about 50% direct radiation interception and this value can be used as a reference for urban trees selection.Further simulations were held to investigate LAI value of maximum direct radiation interception.Performing additional simulations, F. elastica of LAI of 3 intercepted almost 84% of direct radiation and revealed implications about urban trees in practice and its actual LAI.