Electroosmotic micropump for lab‐on‐a‐chip biomedical applications

Lab‐on‐a‐chip (LOC) integrated microfluidics has been a powerful tool for new developments in analytical chemistry. These microfluidic systems enable the miniaturization, integration and automation of complex biochemical assays through the reduction of reagent use and enabling portability. Electroosmotic micropumps could be employed as powerful tools to generate required flow in point of care (POC) devices. In the present study, parallel electroosmotic micropumps are investigated to improve the efficiency of simple micropumps. According to the results, parallel micropumps generate higher flow rate in comparison with conventional electroosmotic pump. In the last decade, a large variety of non‐Newtonian fluids have been utilized in biomedical application but requirements for a POC device such as high efficient driving flow, miniaturization and simple handling of POC devices remain unmet. As a consequence, in this study, power law model as non‐Newtonian fluids that flow through the parallel micropumps are investigated in order to enhance fluid pumping and decreasing voltage requirement.. It is found that as the power law index increases the mass flow rate decreases. Also, the flow rate is almost constant for the higher power law index. Obtained results, demonstrated that parallel micropump could enhance pumping of non‐Newtonian fluid (blood) up to 30%. Copyright © 2016 John Wiley & Sons, Ltd.     

3D FEM analysis,dynamic modeling,and performance assessment of transverse flux PMSG for small‐scale gearless wind energy conversion systems

The transverse flux permanent magnet synchronous generator has a great potential for use in direct‐drive wind energy conversion systems due to its large pole numbers, high torque, and power density. This research work develops dynamic model of a single‐side transverse flux permanent magnet synchronous generator for use in a small‐scale gearless wind energy conversion system. For acquiring the parameters of the considered generator, required for dynamic modeling, 3D finite element model of the machine is developed and analyzed in both magneto‐static and transient modes. Field‐oriented control approach is employed for tracking maximum power point from the variable wind speed. The simulation results illustrate an accurate response of the system to the wind speed variation and proper performance of the developed dynamic model and control approach of the system. Copyright © 2015 John Wiley & Sons, Ltd.     

Mechanical, rheological, and thermal behavior assessments in HDPE/PA-6/EVOH ternary blends with variable morphology

Visco-elastic and dielectric spectra of multiwalled carbon-nanotube reinforced silicon elastomer nanocomposites were used to study relaxation behavior. SEM photomicrographs shows well dispersion of MWCNT in elastomer matrix. In visco-elastic analysis primary relaxation was studied as a function of temperature (?100 to 100 °C) at frequency 1Hz and strain 1 %. The effect of MWCNT loadings on storage modulus, loss modulus, and loss tangent has been studied. The non-linearity in loss tangent, storage modulus and loss modulus was explained on the basis of MWCNT-elastomer interaction and the inter-aggregate attraction of MWCNT. The secondary β relaxation was studied using dielectric relaxation spectra in the frequency range of 0.1 Hz to 10⁶ Hz. The effect of MWCNT loadings on the complex and real parts of impedance was distinctly visible which has been explained on the basis of interfacial polarization of fillers in a heterogeneous medium and relaxation dynamics of polymer chains in the vicinity of fillers. The dielectric formalism has been utilized to further investigate the conductivity and relaxation phenomenon. The ‘percolation limit’ of the MWCNT in the silicon elastomer was found to be in the range of 4 phr loading.     

Preparation of porous PLLA/PCL blend by a combination of PEO phase and NaCl particulate leaching in PLLA/PCL/PEO/NaCl blend

In this study, the ternary blends containing microporosity based on poly(l-lactic acid) (PLLA), poly(ε-caprolactone) (PCL) and polyethylene oxide (PEO) were prepared using an internal mixer via a polymer leaching technique. The particulate leaching is the most widely used technique to create porosity. To introduce macroporosity besides micropores, NaCl particulates were incorporated into the ternary blends at 40–80 wt % and macropores were formed by particulate leaching. Samples porosity were evaluated by calculating the ratio of porous scaffold density (ρ*) to the non-porous material density (ρ _s). The results showed that with an increase in NaCl particulate content, the amount of porosity increased and the distribution of pore size was gradually transformed from monomodal into bimodal form. The porosity plays a key role in governing the compression properties. Mechanical properties are presented by Gibson–Ashby model. Compressive modulus decreased with an increase in NaCl particulate concentration due to the increase in porosity and thinning of pore wall that caused rupture at these weaker spots. Blending and forming of the bio-scaffold can be made using conventional polymer processing equipment. This process seems promising for a large-scale production of porous bio-scaffold of many sizes through an economic method.     

Synthesis of imidazo[2,1-b]thiazoles through the reaction of thiohydantoins and α-bromoketones

Imidazo-fused heterocycles are used as anticancer agents. In this study, some novel imidazo[2,1-b]thiazoles were synthesized from thiohydantoins and α-bromoketones in good yields. This method has the advantages of simple operation, high yields, and mild reaction conditions and uses less toxic and low-cost chemical reagents.     

Carbon nanotubes: properties,synthesis, purification,and medical applications

Current discoveries of different forms of carbon nanostructures have motivated research on their applications in various fields. They hold promise for applications in medicine, gene, and drug delivery areas. Many different production methods for carbon nanotubes (CNTs) have been introduced; functionalization, filling, doping, and chemical modification have been achieved, and characterization, separation, and manipulation of individual CNTs are now possible. Parameters such as structure, surface area, surface charge, size distribution, surface chemistry, and agglomeration state as well as purity of the samples have considerable impact on the reactivity of carbon nanotubes. Otherwise, the strength and flexibility of carbon nanotubes make them of potential use in controlling other nanoscale structures, which suggests they will have a significant role in nanotechnology engineering.     

3D experimental and numerical analysis of wind flow around domed-roof buildings with open and closed apertures

This paper presents experimental and numerical study of airflow distribution around a reduced-scale model of a common type of domed-roof building. Measurements are performed in an open loop wind tunnel. A new modified Counihan scheme is developed for constructing a part-depth atmospheric boundary layer (ABL). Measured quantities include: wind velocity profile, turbulence intensity and airflow pattern around the building. To conduct the experiments, a 1:54 scale model of a real domed-roof building with six windows and an aperture on the roof is fabricated and placed in the test section of the wind tunnel. In addition, using a numerical modeling, turbulent airflow around such scale model in the wind tunnel is simulated and airflow field inside and outside the model as well as ventilating discharge coefficient are computed. It is illustrated that, airflow around this type of building contains complex adjacent recirculation flows. The building with open apertures has acceptable discharge coefficient for ventilation, which can be a factor to ensure comfort condition for residents as well as complying with energy-saving considerations.     

A time-domain noise-coupling technique for continuous-time sigma-delta modulators

In this paper, a time-domain noise-coupling technique based on the pulse width modulation is proposed. The time-domain quantization error is digitally extracted and shaped by an asynchronous digital filter. This digitally filtered quantization error is applied to the quantizer input to increase the modulator’s noise-shaping order. By using this technique in continuous-time sigma-delta modulators, the modulator’s shaping property is significantly enhanced. Comparative analytical calculations and simulation results are presented to estimate the performance of modulators employing the proposed quantizer. System-level simulation results reveal a (L + 2)th order noise-shaping capability of the proposed modulator while it employs only L analog integrators. The effects of main circuit non-idealities in the modulator’s performance are analytically investigated and confirmed by the simulation results.     

Design of CMOS three-stage amplifiers for fast-settling switched-capacitor circuits

In this paper, a time-domain design procedure for fast-settling three-stage amplifiers is presented. In the proposed design approach, the amplifier is designed to settle within a specific time with a given settling accuracy and circuit noise budget by optimizing both the power consumption and silicon die area. Both linear and nonlinear settling regions of three-stage amplifiers are considered and optimal values of the amplifier stages transconductance and compensation capacitors are obtained using the genetic algorithm optimization. Detailed design equations are provided and circuit level simulation results using a 90 nm CMOS technology are presented to evaluate the usefulness of the proposed design scheme respected to the previously reported design approaches.     

IGBDD: Intelligent Grid Based Data Dissemination Protocol for Mobile Sink in Wireless Sensor Networks

Lifetime and energy efficiency are important factors in the design of wireless sensor network. A critical issue during data collection is the formation of energy holes near the sink. Sensors which are located near the sink have to participate in relaying data on behalf of other sensors and thus their energy will be depleted very quickly. Mobile sink movement yields the significant performance gained by decreasing the amount of energy consumption. In this paper, we propose an Intelligent Grid Based Data Disseminating protocol for mobile sink in wireless sensor networks. We have utilized a virtual grid as the protocol’s substructure. In our proposed method, cell heads (CHs) will be selected based on the locations of virtual cross points (CPs) and CPs selection is needless to transfer any required data between neighbor nodes. We have optimized CPs selection using linear programming technique in order to increase network lifetime. By selecting the CHs based on our proposed algorithm, data will be disseminated toward the sink. Our data dissemination protocol is simple and has low overhead to construct and maintain. Also, we have presented a new method for sink location update which leads to the least cost in data transfer. Simulation results illustrate that by utilizing hierarchical functionality and selecting appropriate CPs and consequently selecting CHs, energy consumption will be decreased in comparison with other presented methods which directly lead to network lifetime increment. Also by determining an optimal cell size, packet delivery rate will be improved noticeably.