全文获取类型
收费全文 | 3392篇 |
免费 | 181篇 |
国内免费 | 16篇 |
专业分类
电工技术 | 64篇 |
综合类 | 8篇 |
化学工业 | 768篇 |
金属工艺 | 79篇 |
机械仪表 | 83篇 |
建筑科学 | 115篇 |
矿业工程 | 3篇 |
能源动力 | 210篇 |
轻工业 | 304篇 |
水利工程 | 38篇 |
石油天然气 | 81篇 |
无线电 | 426篇 |
一般工业技术 | 644篇 |
冶金工业 | 115篇 |
原子能技术 | 14篇 |
自动化技术 | 637篇 |
出版年
2024年 | 14篇 |
2023年 | 121篇 |
2022年 | 234篇 |
2021年 | 275篇 |
2020年 | 184篇 |
2019年 | 180篇 |
2018年 | 225篇 |
2017年 | 170篇 |
2016年 | 176篇 |
2015年 | 115篇 |
2014年 | 141篇 |
2013年 | 273篇 |
2012年 | 177篇 |
2011年 | 195篇 |
2010年 | 139篇 |
2009年 | 137篇 |
2008年 | 103篇 |
2007年 | 69篇 |
2006年 | 77篇 |
2005年 | 70篇 |
2004年 | 51篇 |
2003年 | 37篇 |
2002年 | 38篇 |
2001年 | 33篇 |
2000年 | 25篇 |
1999年 | 32篇 |
1998年 | 35篇 |
1997年 | 20篇 |
1996年 | 24篇 |
1995年 | 14篇 |
1994年 | 18篇 |
1993年 | 22篇 |
1992年 | 20篇 |
1991年 | 8篇 |
1990年 | 8篇 |
1989年 | 15篇 |
1988年 | 17篇 |
1987年 | 5篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1983年 | 8篇 |
1982年 | 6篇 |
1981年 | 7篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1978年 | 8篇 |
1977年 | 4篇 |
1976年 | 7篇 |
1974年 | 4篇 |
排序方式: 共有3589条查询结果,搜索用时 15 毫秒
71.
Reham Hammad Reda Badr Aglan Shaymaa A. Mohammed Eman Abu-elnasr Awad Marwa A. Elsaid Hanan M. Bedair Seham K. Khirala Mohamed A Selim Asmaa A. Abo Elqasem Areej Rushdi Mohamed Ali Omaima I. Abo-Elkheir Eman F. Sanad Nadia M. Hamdy 《International journal of molecular sciences》2022,23(20)
Virus-related hepatocellular carcinoma (HCC) pathogenesis involves liver inflammation, therefore, despite successful treatment, hepatitis C virus (HCV) may progress to HCC from initiated liver cirrhosis. Cytotoxic T cells (Tcs) are known to be involved in HCV-related cirrhotic complications and HCC pathogenesis. The inhibitory checkpoint leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is expressed on Tcs. Therefore, we aimed to determine whether the Tc expression level of LAIR-1 is associated with HCC progression and to evaluate LAIR-1 expression as a noninvasive biomarker for HCC progression in the context of liver cirrhosis related to HCV genotype 4 (G4) in Egyptian patients’ peripheral venous blood liquid biopsy. A total of 64 patients with HCC and 37 patients with liver cirrhosis were enrolled in this case-controlled study, and their LAIR-1 expression on Tc related to the progression of liver cirrhosis was examined and compared to that of the apparently healthy control group (n = 20). LAIR-1 expression was analyzed using flow cytometry. Results: The HCC group had significantly higher LAIR-1 expression on Tc and percentage of Tc positive for LAIR-1 (LAIR-1+Tc%) than the HCV G4-related liver cirrhosis group. LAIR-1+Tc% was correlated with the HCC surrogate tumor marker AFP (r = 0.367, p = 0.001) and insulin resistance and inflammation prognostic ratios/indices. A receiver operating characteristic (ROC) curve revealed that adding LAIR-1+Tc% to AFP can distinguish HCC transformation in the Egyptian patients’ cohort. Upregulated LAIR-1 expression on Tc could be a potential screening noninvasive molecular marker for chronic inflammatory HCV G4 related liver cirrhosis. Moreover, LAIR-1 expression on Tc may be one of the players involved in the progression of liver cirrhosis to HCC. 相似文献
72.
Qusai Q. Abuein Mohammed Q. Shatnawi Muneer Bani Yassein Reem Mahafza 《Multimedia Tools and Applications》2018,77(14):17557-17571
The accuracy of searches for visual data elements, as well as other types of information, depends on the terms used by the user in the input query to retrieve the relevant results and to reduce the irrelevant ones. Most of the results that are returned are relevant to the query terms, but not to their meaning. For example, certain types of web contents hold hidden information that traditional search engines are unable to retrieve. Searching for the mathematical construct of 1/x using Google will not result in the retrieval of the documents that contain the mathematically equivalent expressions (i.e. x?1). Because conventional search engines fall short of providing math-search capabilities. One of these capabilities is the ability of these search engines to detect the mathematical equivalence between users’ quires and math contents. In addition, users sometimes need to use slang terms, either to retrieve slang-based visual data (e.g. social media content) or because they do not know how to write using classical form. To solve such a problem, this paper proposed an AI-based system for analysing multilingual slang web contents so as to allow a user to retrieve web slang contents that are relevant to the user’s query. The proposed system presents an approach for visual data analytics, and it also enables users to analyse hundreds of potential search results/web pages by starting an informed friendly dialogue and presenting innovative answers. 相似文献
73.
Sofiane Bououden Mohammed Chadli Lixian Zhang Ting Yang 《International Journal of Control, Automation and Systems》2016,14(1):51-58
This study investigates the problem of robust model predictive control (RMPC) for active suspension systems with time-varying delays and input constraints. The uncertainty is of convex polytopic type. Based on the Lyapunov-Krasovskii functional method, sufficient stability conditions of the time-varying delays systems are derived by linear matrix inequalities (LMIs) terms. At each time set, a feasible state feedback is obtained by minimizing an upper bound of the ‘worst-case’ quadratic objective function over an infinite horizon subject to constraints on inputs. Finally, a quarter-vehicle model is exploited to demonstrate the effectiveness of the proposed method. 相似文献
74.
Mohammed H. AL Mughram Mohini S. Ghatge Glen E. Kellogg Martin K. Safo 《International journal of molecular sciences》2023,24(1)
Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, serves as a cofactor for scores of B6-dependent (PLP-dependent) enzymes involved in many cellular processes. One such B6 enzyme is dopa decarboxylase (DDC), which is required for the biosynthesis of key neurotransmitters, e.g., dopamine and serotonin. PLP-dependent enzymes are biosynthesized as apo-B6 enzymes and then converted to the catalytically active holo-B6 enzymes by Schiff base formation between the aldehyde of PLP and an active site lysine of the protein. In eukaryotes, PLP is made available to the B6 enzymes through the activity of the B6-salvage enzymes, pyridoxine 5′-phosphate oxidase (PNPO) and pyridoxal kinase (PLK). To minimize toxicity, the cell keeps the content of free PLP (unbound) very low through dephosphorylation and PLP feedback inhibition of PNPO and PLK. This has led to a proposed mechanism of complex formation between the B6-salvage enzymes and apo-B6 enzymes prior to the transfer of PLP, although such complexes are yet to be characterized at the atomic level, presumably due to their transient nature. A computational study, for the first time, was used to predict a likely PNPO and DDC complex, which suggested contact between the allosteric PLP tight-binding site on PNPO and the active site of DDC. Using isothermal calorimetry and/or surface plasmon resonance, we also show that PNPO binds both apoDDC and holoDDC with dissociation constants of 0.93 ± 0.07 μM and 2.59 ± 0.11 μM, respectively. Finally, in the presence of apoDDC, the tightly bound PLP on PNPO is transferred to apoDDC, resulting in the formation of about 35% holoDDC. 相似文献
75.
Mohammed Al-Duais Lars Müller Volker Böhm Gottfried Jetschke 《European Food Research and Technology》2009,228(5):813-821
In the framework of standardisation of new healthy food sources, this paper aimed to study the total phenolics and the antioxidant
power of Cyphostemma digitatum (Vitaceae) in water and ethanol extracts, using 96-well micro plates with BMG FLUOstar Optima micro plate reader. Total phenolics
by Folin–Ciocalteu method in the water extracts were significantly lower after processing, decreasing from 1.41 ± 0.06 g GAE/100 g
in the raw leaves to 0.80 ± 0.08 g GAE/100 g in the processed sample; the ethanol extract revealed the same trend with higher
values, decreasing from 1.95 ± 0.03 to 1.56 ± 0.12 g GAE/100 g. The antioxidant capacity was elucidated by four methods: TEAC,
DPPH, FRAP and ORAC. No or very weak correlations were found between antioxidant assays and total phenolics; this confirms
that the antioxidant capacity could be attributed to other molecules. The ORAC assay proved to be more powerful than the other
assays; it showed 103.3 ± 2.5 mmol/100 g Trolox equivalents in the raw leaves ethanol extract and 91.9 ± 3.0 mmol/100 g in
the processed sample. ORAC assay showed the opposite for the water extract where the antioxidant capacity increased from 16.7 ± 0.2
to 41.7 ± 2.7 mmol/100 g Trolox equivalents after processing, which could be attributed to new water-soluble compounds generated
in the consumed form. 相似文献
76.
Habibullah Khalilullah Deepak K. Agarwal Mohamed J. Ahsan Surender S. Jadav Hamdoon A. Mohammed Masood Alam Khan Salman A. A. Mohammed Riaz Khan 《International journal of molecular sciences》2022,23(12)
Newly designed series of indole-containing pyrazole analogs, pyrazolinylindoles, were synthesized, and their structures were confirmed based on the spectral data of the 1H NMR, 13C NMR, and HR-MS analyses. Preliminary anti-cancer activity testings were carried out by the National Cancer Institute, United States of America (NCI, USA). Compounds HD02, HD05, and HD12 demonstrated remarkable cytotoxic activities against nine categories of cancer types based cell line panels which included leukemia, colon, breast, melanoma, lungs, renal, prostate, CNS, and ovarian cancer cell lines. The highest cytotoxic effects were exhibited by the compounds HD02 [1-(5-(1-H-indol-3-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-phenylethanone], HD05 [1-(3-(4-chlorophenyl)-5-(1H-indol-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-2-phenoxyethanone], and HD12 [(3-(4-chlorophenyl)-5-(1H-indol-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanone] against some of the 56 types of NCI-based cell lines in different panels. Compound HD05 showed the maximum range of cancer cell growth inhibitions against all categories of the cell lines in all nine panels. On average, in comparison to the referral standard, imatinib, at a dose level of 10 µM, the HD05 showed significant activity against leukemia in the range of 78.76%, as compared to the imatinib at 9% of cancer cells’ growth inhibitions. Molecular docking simulation studies were performed in silico on the epidermal growth factor receptor (EGFR) tyrosine kinase, in order to validate the activity. 相似文献
77.
Mohammed Alomair Stelios Georgiou Stella Stylianou 《Quality and Reliability Engineering International》2021,37(1):90-107
Since their introduction by Box and Hunter, resolution criteria have been widely used when comparing regular fractional factorials designs. In this article, we investigate how a generalized resolution criterion can be used to assess some recently developed three-level screening designs, such as definitive screening designs (DSDs) and screening designs from weighing matrices. The aim of this paper is to capture the projection properties of those three-level screening designs, complementing the work of Deng and Tang, who used generalized resolution and minimum aberration criteria for ranking different two-level designs, particularly Plackett-Burman and other nonregular factorial designs. An advantage of generalized resolution, extended here to work on three-level designs, is that it offers a useful criterion for ranking three-level screening designs, whereas the Deng and Tang resolution is used mainly for the assessment of two-level designs. In addition, we applied a projection estimation capacity (PEC) criterion to select three-level screening designs with desirable properties. Practical examples and the best projections of the designs are presented in tables. 相似文献
78.
Samet Güler Mohammed A. Algarni Mohammad Z. Shaqura Hassan Jaleel Mohamed A. Mabrok Jiming Jiang Yimeng Lu Jeff S. Shamma 《野外机器人技术杂志》2019,36(5):973-1003
The ground robotics challenge in the Mohammed Bin Zayed International Robotics Challenge required a ground vehicle equipped with a robotic arm to autonomously locate a panel, select a proper size wrench among several options mounted on the panel, and use the wrench to rotate a valve. Autonomy was the critical factor in this challenge, which required the teams to devise algorithms that can operate successfully in a semistructured environment without human supervision. This paper presents the approaches taken by team KAUST to meet this challenge, ranging from in‐house hardware designs to algorithm integration and customization. We separated the whole objective into three interconnected tasks: Navigation, perception, and manipulation. For the navigation task, we developed a basic robotic exploration scheme to find the panel front side where the wrenches were present. For the perception task, we integrated common object detection algorithms with neural networks to identify the proper size wrench precisely. For successful manipulation, we designed and built a custom gripper, which was inspired by the common grasping behavior of a human hand under tight clearance conditions. The modular structure of the proposed approach allowed the team to progress in several subtasks simultaneously. However, the interconnection between the subtasks necessitated a reliable integration framework between these modules for effective implementation. We tuned our algorithms in extensive experimental studies and eventually obtained 10 consecutive successful navigation runs, 96% true wrench detection rate, and high success rate in wrench grasping. Furthermore, successful complete tests proved the reliability and repeatability of our system. 相似文献
79.
The methanol extract from mature fruits of Aristotelia chilensis (Mol) Stuntz (Elaeocarpaceae) showed antioxidant activities and cardioprotective effects on acute ischemia/reperfusion performed in rat heart in vivo. This extract protected animals from heart damage by the incidence of reperfusion dysrythmias, and the no-recovery of sinus rhythm. On the other hand, the MeOH extract of the fruit was able to prevent these harmful events in the animal’s heart by diminishing lipid oxidation and reducing the concentration of thiobarbituric acid reactive substances (TBARS), a lipid peroxidation index. In addition, MeOH extract of A. chilensis was evaluated for DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, crocin radical scavenging, oxygen radical absorption capacity (ORAC), ferric reducing antioxidant power (FRAP), an estimation of lipid peroxidation in liposomes through the inhibition of formation of TBARS. MeOH extract was found to have IC50 of 1.62 ppm against DPPH and 2.51 ppm against TBARS, compared with the juice, whose IC50 was 12.1 ppm and 9.58 ppm against DPPH and TBARS formation, respectively. Antioxidant activities of MeOH extract were strongly correlated with total polyphenol content. Consistent with this finding, MeOH had the greatest ORAC and FRAP values as percentage of activity. These results show that these fruits could be useful as antioxidant, cardioprotective and nutraceutical sources. 相似文献
80.
The effect of high-pressure (HP) pretreatment on oil uptake of potato slices is examined in this paper. Potato slices were
treated either by HP or thermal blanching, or a combination of thermal blanching followed by HP prior to frying. The effect
of HP on starch gelatinization and potato microstructure was assessed by differential scanning calorimeter and environmental
scanning electron microscope (ESEM), respectively. After treatments, the slices were fried in sunflower oil at 185 °C for
a predetermined time. Frying time was either kept constant (4 min) or varied according to the time needed to reach a desired
moisture content of ≈2%. The high pressure applied in this study was found not to be sufficient to cause a significant degree
of starch gelatinization. Analysis of the ESEM images showed that blanching had a limited effect on cell wall integrity. HP
pretreatment was found to increase the oil uptake marginally. When frying for a fixed time, the highest total oil content
was found in slices treated at 200 MPa for 5 min. The oil content was found to increase significantly (p < 0.05) to 41.23 ± 1.82 compared to 29.03 ± 0.21 in the control slices. The same effect of pressure on oil content was found
when the time of frying varied. On the other hand, HP pretreatment was found to decrease the frying time required to achieve
a given moisture content. Thus, high-pressure pretreatment may be used to reduce the frying time, but not oil uptake. 相似文献