Jessica Mendes Nadal  Mona Lisa Simionatto Gomes  Débora Maria Borsato  Martinha Antunes Almeida  Fernanda Malaquias Barboza  Sônia Faria Zawadzki 《Drug development and industrial pharmacy》2016,42(11):1813-1824

This article aimed to improve the relative solubility and dissolution rate of ferulic acid (FA) by the use of spray-dried solid dispersions (SDs) in order to ensure its in vitro antioxidant potential and to enhance its in vivo anti-platelet effect. These SDs were prepared by spray-drying at 10 and 20% of drug concentration using polyvinylpyrrolidone K30 (PVP-K30), polyethylene glycol 6000 (PEG 6000) and poloxamer-188 (PLX-188) as carriers. SDs and physical mixtures (PM) were characterized by SEM, XRPD, FTIR spectroscopy and TGA analysis. Spray-dried SDs containing FA were successfully obtained. Relative solubility of FA was improved with increasing carrier concentration. PVP-K30 and PEG 6000 formulations showed suitable drug content values close to 100%, whereas PLX-188 presented mean values between 70 and 90%. Agglomerates were observed depending on the carrier used. XRPD patterns and thermograms indicated that spray-drying led to drug amorphization and provided appropriate thermal stability, respectively. FTIR spectra demonstrated no remarkable interaction between carrier and drug for PEG 6000 and PLX-188 SDs. PVP-K30 formulations had changes in FTIR spectra, which denoted intermolecular O–H???O?=?C bonds. Spray-dried SDs played an important role in enhancing dissolution rate of FA when compared to pure drug. The free radical-scavenging assay confirmed that the antioxidant activity of PEG 6000 10% SDs was kept. This formulation also provided a statistically increased in vivo anti-platelet effect compared to pure drug. In summary, these formulations enhanced relative solubility and dissolution rate of FA and chosen formulation demonstrated suitable in vitro antioxidant activity and improved in vivo anti-platelet effect.  相似文献   

    

Nikki Kumari  Rashmi Kumari  Ankita Dua  Mona Singh  Roushan Kumar  Poonam Singh  Susan Duyar-Ayerdi  Sunila Pradeep  Akinyemi I. Ojesina  Roshan Kumar 《Molecular nutrition & food research》2024,68(6):2300688

The human gut microbiota regulates estrogen metabolism through the “estrobolome,” the collection of bacterial genes that encode enzymes like β-glucuronidases and β-glucosidases. These enzymes deconjugate and reactivate estrogen, influencing circulating levels. The estrobolome mediates the enterohepatic circulation and bioavailability of estrogen. Alterations in gut microbiota composition and estrobolome function have been associated with estrogen-related diseases like breast cancer, enometrial cancer, and polycystic ovarian syndrome (PCOS). This is likely due to dysregulated estrogen signaling partly contributed by the microbial impacts on estrogen metabolism. Dietary phytoestrogens also undergo bacterial metabolism into active metabolites like equol, which binds estrogen receptors and exhibits higher estrogenic potency than its precursor daidzein. However, the ability to produce equol varies across populations, depending on the presence of specific gut microbes. Characterizing the estrobolome and equol-producing genes across populations can provide microbiome-based biomarkers. Further research is needed to investigate specific components of the estrobolome, phytoestrogen-microbiota interactions, and mechanisms linking dysbiosis to estrogen-related pathology. However, current evidence suggests that the gut microbiota is an integral regulator of estrogen status with clinical relevance to women's health and hormonal disorders.  相似文献   

    

Jae Won Choi;Chanho Park;Gil-Sung Kim;Jung-Min Cho;No-Won Park;Yun-Ho Kim;Min Young Jung;Seo Hyoung Chang;Md Sabbir Akhanda;Bellave Shivaram;Steven P. Bennett;Mona Zebarjadi;Sang-Kwon Lee; 《Small (Weinheim an der Bergstrasse, Germany)》2024,20(43):2403315

Iron rhodium (FeRh) undergoes a first-order anti-ferromagnetic to ferromagnetic phase transition above its Curie temperature. By measuring the anomalous Nernst effect (ANE) in (110)-oriented FeRh films on Al2O3 substrates, the ANE thermopower over a temperature range of 100–350 K is observed, with similar magnetic transport behaviors observed for in-plane magnetization (IM) and out-of-plane magnetization (PM) configurations. The temperature-dependent magnetization–magnetic field strength (M–H) curves revealed that the ANE voltage is proportional to the magnetization of the material, but additional features magnetic textures not shown in the M-H curves remained intractable. In particular, a sign reversal occurred for the ANE thermopower signal near zero field in the mixed-magnetic-phase films at low temperatures, which is attributed to the diamagnetic properties of the Al2O3 substrate. Finite element method simulations associated with the Heisenberg spin model and Landau–Lifshitz–Gilbert equation strongly supported the abnormal heat transport behavior from the Al2O3 substrate during the experimentally observed magnetic phase transition for the IM and PM configurations. The results demonstrate that FeRh films on an Al2O3 substrate exhibit unusual behavior compared to other ferromagnetic materials, indicating their potential for use in novel applications associated with practical spintronics device design, neuromorphic computing, and magnetic memory.  相似文献   

    

Reza Sheikhrabori  Majid Aminnayeri  Mona Ayoubi 《Quality and Reliability Engineering International》2018,34(1):27-36

Change point estimation is a useful concept in time series models that could be applied in several fields such as financing, quality control. It helps to decrease costs of decision making and production by monitoring stock market and production lines, respectively. In this paper, the maximum likelihood technique is developed to estimate change point at which the stationary AR(1) model changes to a nonstationary process. Filtering and smoothing of dynamic linear model are used to estimate unknown parameters after change point. We also assume that correlation exists between samples' statistics. Simulation results show the effectiveness of the proposed estimators to estimate the change point of stationary. In addition based on Shewhart control chart, filtering has a better accuracy in comparison to smoothing. A real example is provided to illustrate the application.  相似文献   

    

Hanan M. F. Abd El‐Wahab  Mona A. Mohamed  Hanaa H. El Sayed  Alshimaa E. Bauomy 《Journal of Food Biochemistry》2017,41(1)

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Ahmed M. Awad Abouelata  S. M. Aly Abdallah  Mohamed H. Sorour  Nourhan A. Shawky  Mona A. Abdel-Fatah 《应用聚合物科学杂志》2020,137(39):49190

Hollow fiber membrane (HF) is considered one of the prevalent materials for water treatment; its effectiveness is controlled by permeation and mechanical characteristics. In this study, HF membrane surface was stimulated using electrochemical technique, where binary system of stainless steel cylinder and graphite rod electrodes was used into electrolytic solution of sodium acetate 0.1 M as electrolyte. Two pH of acidic medium (pH = 3.5) and alkaline medium (pH = 8.5) were prepared and different potential between 2 and 10 V were applied. EDX analysis of HF membrane surface revealed the formation of sodium ions on the surface of HF membrane with maximum content of Na⁺ ions 1.84%. Also, HF membrane surface showed variation of roughness (R _a) as, HF membrane surface may undergo distortion by using aggressive conditions of high electric potential (7.5–10 V), The measured raw HF membrane (R _a) was 34.8 nm, while, after electrochemical modification in alkaline medium R _a showed higher values 36, 37, and 41 nm using 2, 2.5, and 5 V, respectively. While, after electrochemical modification in acidic medium (R _a) showed 35, 39, 42, 49, 52 nm for 2, 2.5, 5, 7.5, and 10 V, respectively. Moreover, tensile strength Young's modulus, break stress and break strain were measured after electrochemical modification in both acidic and alkaline mediums and maximum porosity value 76.84% was observed after 30 min in acidic medium.  相似文献   

    

Mona MY Elghandour  Mohamed ZM Salem  Ralf Greiner  Abdelfattah ZM Salem 《Journal of the science of food and agriculture》2018,98(14):5313-5321

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Himanshu Khanna  Mona Aggarwal  Swaran Ahuja 《International Journal of Communication Systems》2018,31(1)

In this work, an amplify‐and‐forward variable‐gain relayed mixed RF‐FSO system is studied. The considered dual‐hop system consists of a radio frequency (RF) link followed by a free space optical (FSO) channel. The RF link is affected by short‐term multipath fading and long‐term shadowing effects and is assumed to follow the generalized‐K fading distribution that approximates accurately several important distributions often used to model communication channels. The FSO channel experiences fading caused by atmospheric turbulence that is modeled by the gamma‐gamma distribution characterizing moderate and strong turbulence conditions. The FSO channel also suffers path loss and pointing error induced misalignment fading. The performance of the considered system is analyzed under the collective influence of distribution shaping parameters, pointing errors that result in misalignment fading, atmospheric turbulence, and path loss. The moment‐generating function of the Signal power to noise power ratio measured end‐to‐end for this system is derived. The cumulative distribution function for the Signal power to noise power ratio present between the source and destination receiver is also evaluated. Further, we investigate the error and outage performance and the average channel capacity for this system. The analytical expressions in closed form for the outage probability, symbol and bit error rate considering different modulation schemes and channel capacity are also derived. The mathematical expressions obtained are also demonstrated by numerical plots.  相似文献   

    

Nadia A. Mohamed  Nahed A. Abd El-Ghany  Mona M. Fahmy  Perihan A. Khalaf-Alla 《国际聚合物材料杂志》2018,67(2):68-77

Novel polymaleimide containing dibenzoyl hydrazine pendant group, poly[N-benzoyl-4-(N-maleimido)-phenyl hydrazide], and its metal complexes have been synthesized. Their antimicrobial activity against Bacillus subtilis, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Escherichia coli bacteria and that against Aspergillus fumigatus, Syncephalastrum racemosum, Geotrichum candidum, and Candida albicans fungi were investigated. The polymer–metal complexes showed better antimicrobial activity than that of the parent polymer. The inhibition of the growth of the microbes remarkably depends on the type of the metal in the complexes. The polymer–Co(II) and the polymer–Cd(II) complexes are more potent in inhibition of the tested microbes growth than the rest of the prepared complexes.  相似文献   

    

Naiming Liu  S. Emad Rezaei  Wade Aaron Jensen  Shaowei Song  Zhifeng Ren  Keivan Esfarjani  Mona Zebarjadi  Jerrold Anthony Floro 《Advanced functional materials》2019,29(38)

A β‐FeSi₂–SiGe nanocomposite is synthesized via a react/transform spark plasma sintering technique, in which eutectoid phase transformation, Ge alloying, selective doping, and sintering are completed in a single process, resulting in a greatly reduced process time and thermal budget. Hierarchical structuring of the SiGe secondary phase to achieve coexistence of a percolated network with isolated nanoscale inclusions effectively decouples the thermal and electrical transport. Combined with selective doping that reduces conduction band offsets, the percolation strategy produces overall electron mobilities 30 times higher than those of similar materials produced using typical powder‐processing routes. As a result, a maximum thermoelectric figure of merit ZT of ≈0.7 at 700 °C is achieved in the β‐FeSi₂–SiGe nanocomposite.  相似文献