Evaluation of IP over WDM Network Architectures

The commonly used IP-backbone network architecture of today is IP/ATM/SDH/WDM. This architecture has many redundant functionalities and is not optimized to transport IP traffic. New approaches for simplified network architectures try to eliminate redundant functionalities and to decrease the protocol overhead and thereby transport IP as efficiently as possible over WDM-based optical networks. EURESCOM project P918 Integration of IP-over-optical networks: networking and management investigated scenarios for optimized IP transport in WDM-based backbone networks. In this paper, three architectures, namely Gigabit Ethernet, Packet over Sonet/SDH and Dynamic Packet Transport are investigated and evaluated as an alternative to the IP/ATM/SDH/WDM architecture.     

Analysis of structural modifications in γ-irradiated PbO–B2O3–SiO2 glasses by FTIR spectroscopy

The effect of γ-irradiation on the structure of lead borosilicate glasses of varying composition has been probed by FTIR spectroscopy, before and immediately after γ-irradiation. The glasses were irradiated at Calliope ⁶⁰Co plant (RC ENEA Casaccia, Rome), and the spectra were recorded after absorbed doses of 50 Gy, 500 Gy, and 4 kGy. The structural analysis have been made considering both the effect of composition and of irradiation. The experimental results clearly indicate that after irradiation a significant change in structure of borosilicate glass network is observed.     

Efficient tracking of moving objects using a relational database

Tracking uncooperative moving objects by means of radar is a complex task due to clutter and association problems in multi-target scenarios. An approach to solve this problem is probabilistic multiple hypothesis tracking (PMHT). This method combines classical track filtering with a likelihood ratio test for the estimation of the plot-to-track association. The basics of PMHT and similar algorithms have gained much attention recently. However, the efficient implementation of real world applications of this technique still represents a challenging task. Since a common requirement in this context is the reliable storage of track data in a database, an implementation of the tracker's calculation inside a database management system (DBMS) using SQL views is desirable. A naive implementation of PMHT using a commercial DBMS, however, usually leads to performance problems because of the high frequency of measurement updates. In this paper, we propose possible optimizations for solving these performance problems. Their usage leads to a dramatic run-time improvement in our sample case and makes the implementation of PMHT in a database context feasible.     

Efficient computer implementation of the renormalized coupled-cluster methods: The R-CCSD[T], R-CCSD(T), CR-CCSD[T], and CR-CCSD(T) approaches

The recently proposed renormalized (R) and completely renormalized (CR) coupled-cluster (CC) methods of the CCSD[T] and CCSD(T) types have been implemented using recursively generated intermediates and fast matrix multiplication routines. The details of this implementation, including the complete set of equations that have been used in writing efficient computer codes, memory requirements, and typical CPU timings, are discussed. The R-CCSD[T], R-CCSD(T), CR-CCSD[T], and CR-CCSD(T) computer codes and similar codes for the standard CC methods, including the LCCD, CCD, CCSD, CCSD[T], and CCSD(T) approaches, have been incorporated into the gamess package. Information about the main features of this new set of CC programs is provided.     

An evaluation tool for design quality: PFI sheltered housing

The complex procurement process entailed by the private finance initiative (PFI) means that clients need new capacities to manage their relationships with bidders and to assess project proposals if the desired level of design quality is to be achieved. To assist local authorities in their client role, a new Architectural Design Quality Evaluation Tool was developed. The aim was to improve the quality of design in residential sheltered housing, procured through the PFI. The tool was developed for and applied to a programme that will see the replacement of a local authority's entire sheltered housing stock. The tool has two functions: (1) to inform the client's assessment process and assist with the selection of the preferred bidding consortium through a series of stages in the PFI process; and (2) to improve the quality of all the submitted designs through an iterative process. Although several existing mechanisms are available for evaluating the performance attributes of buildings, few also tackle the less tangible amenity attributes, which are vital to the feeling of home. The new tool emphasizes the amenity attributes without neglecting performance.     

Computer-Aided Search for 5-Arylideneimidazolone Anticancer Agents Able To Overcome ABCB1-Based Multidrug Resistance

ABCB1 modulation is an interesting strategy in the search for new anticancer agents that can overcome multidrug resistance (MDR). Hence, 17 new 5-arylideneimidazolones containing an amine moiety, as potential ABCB1 inhibitors, were designed, synthesized, and investigated. The series was tested in both parental (PAR) and multidrug-resistant (MDR) ABCB1-overexpressing T-lymphoma cancer cells using cytotoxicity assays. The ABCB1-modulating activity was examined in rhodamine 123 accumulation tests, followed by Pgp-Glo™ Assay to determine the influence of the most active compounds on ATPase activity. Lipophilic properties were assessed both, in silico and experimentally (RP-TLC). Pharmacophore-based molecular modelling toward ABCB1 modulation was performed. The studies allowed the identification of anticancer agents (p-fluorobenzylidene derivatives) more potent than doxorubicin, with highly selective action on MDR T-lymphoma cells (selectivity index >40). Most of the investigated compounds showed ABCB1-modulating action; in particular, two 5-benzyloxybenzylidene derivatives displayed activity nearly as strong as that of tariquidar.     

Impedance analysis of a phosphatidylcholine-phosphatidylethanolamine system in bilayer lipid membranes

Electrochemical impedance spectroscopy was used for the study of two-component lipid membranes. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were to be investigated, because of their presence in biological membranes. Capacitance values of pure components are 0.62 and 0.32 μF cm⁻², respectively. The 1:1 complex was formed during formation of the PC-PE lipid membrane. Formation of the complex can explain the deviation from the additivity rule. This equilibrium was described by mathematical equations and was further verified experimentally. Adequate equations let us calculate such parameters as: capacitance of the complex molecule, area occupied by the complex molecule as well as the stability constant of the complex.     

Glutathione Deficiency during Early Postnatal Development Causes Schizophrenia-Like Symptoms and a Reduction in BDNF Levels in the Cortex and Hippocampus of Adult Sprague–Dawley Rats

Growing body of evidence points to dysregulation of redox status in the brain as an important factor in the pathogenesis of schizophrenia. The aim of our study was to evaluate the effects of l-buthionine-(S,R)-sulfoximine (BSO), a glutathione (GSH) synthesis inhibitor, and 1-[2-Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride (GBR 12909), a dopamine reuptake inhibitor, given alone or in combination, to Sprague–Dawley pups during early postnatal development (p5–p16), on the time course of the onset of schizophrenia-like behaviors, and on the expression of brain-derived neurotrophic factor (BDNF) mRNA and its protein in the prefrontal cortex (PFC) and hippocampus (HIP) during adulthood. BSO administered alone decreased the levels of BDNF mRNA and its protein both in the PFC and HIP. Treatment with the combination of BSO + GBR 12909 also decreased BDNF mRNA and its protein in the PFC, but in the HIP, only the level of BDNF protein was decreased. Schizophrenia-like behaviors in rats were assessed at three time points of adolescence (p30, p42–p44, p60–p62) and in early adulthood (p90–p92) using the social interaction test, novel object recognition test, and open field test. Social and cognitive deficits first appeared in the middle adolescence stage and continued to occur into adulthood, both in rats treated with BSO alone or with the BSO + GBR 12909 combination. Behavior corresponding to positive symptoms in humans occurred in the middle adolescence period, only in rats treated with BSO + GBR 12909. Only in the latter group, amphetamine exacerbated the existing positive symptoms in adulthood. Our data show that rats receiving the BSO + GBR 12909 combination in the early postnatal life reproduced virtually all symptoms observed in patients with schizophrenia and, therefore, can be considered a valuable neurodevelopmental model of this disease.     

Speed Control of DC Motor with MRPID Controller in the Presence of Noise

Speed control of a DC motor has always been a challenge because of its variable torque. But it becomes more challenging when noise enters the system at its input. Therefore, there is a need of more advanced controllers. In this paper, a multi-resolution proportional integral derivative (MRPID) controller has been proposed to be utilized to control the speed of a DC motor. It works well even in the presence of noise as compared to the conventional PID controller. Also, performance of a PID controller deteriorates when nonlinearity or uncertainty arises in the system. This degraded performance can be improved by utilizing the multi-resolution property of wavelets, which decomposes the error signal into various frequency components. Further, wavelet coefficients of these decompositions are used to generate the control signal for controlling speed of a DC motor. In this paper, performances of a MRPID, a fractional order PID (FOPID) and a conventional PID controllers are compared in the presence of noise for speed control of a DC motor. The results obtained using a MRPID controller are observed to be better in terms of improved transient characteristics and disturbance rejection for a DC motor as compared to those obtained with PID and FOPID controllers.