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541.
Lorena Cristina Miranda Barbosa Monique Santos Thiago Luiz Lara Oliveira Guilherme Ferreira Gomes Antonio Carlos Ancelotti Junior 《Polymer Engineering and Science》2019,59(11):2185-2194
This article investigated the effect of moisture on the tensile strength and in‐plane shear of laminated composites. For this, the results of a composite system based on a new thermoplastic Elium® 150 resin were compared to a traditional epoxy resin result. Both composites were fabricated via VARTM using a 0/90° plain weave carbon fiber fabric. For the non‐conditioned specimens, the thermoplastic composites presented 30% more tensile resistance in comparison to epoxy composites. For conditioned specimens, this difference was 14%. These results were related to plasticization, which tends to favor the polymer softening providing a greater matrix plastic deformation, promoting a ductile fracture of the composite. On the other hand, the in‐plane shear properties were 30% higher for the thermosetting laminates for both conditions. In this case, moisture may have favored the formation of surface cracks and weakened the fiber/matrix interfacial adhesion. Additional analysis based on design of experiments has shown that the Elium® 150 resin significantly affects all responses and presented in fact a better behavior in comparison to Epoxy resin. While the conditioning effects have featured a statistically noticeable contribution to the tensile strength, the presence of the moisture did not provide a significant enhancement to the in‐plane shear strength. Besides that, the unknown fractographic aspects of the fracture surfaces of both composites were used as a complementary tool for the mechanical characterization. POLYM. ENG. SCI., 59:2185–2194, 2019. © 2019 Society of Plastics Engineers 相似文献
542.
543.
Ling Ding;Zhenbin Lyu;Teodora-Adriana Perles-Barbacaru;Adela Ya-Ting Huang;Baoping Lian;Yifan Jiang;Tom Roussel;Christina Galanakou;Suzanne Giorgio;Chai-Lin Kao;Xiaoxuan Liu;Juan Iovanna;Monique Bernard;Angèle Viola;Ling Peng; 《Advanced materials (Deerfield Beach, Fla.)》2024,36(7):2308262
Bioimaging is a powerful tool for diagnosing tumors but remains limited in terms of sensitivity and specificity. Nanotechnology-based imaging probes able to accommodate abundant imaging units with different imaging modalities are particularly promising for overcoming these limitations. In addition, the nanosized imaging agents can specifically increase the contrast of tumors by exploiting the enhanced permeability and retention effect. A proof-of-concept study is performed on pancreatic cancer to demonstrate the use of modular amphiphilic dendrimer-based nanoprobes for magnetic resonance (MR) imaging (MRI) or MR/near-infrared fluorescence (NIRF) multimodality imaging. Specifically, the self-assembly of an amphiphilic dendrimer bearing multiple Gd3+ units at its terminals, generates a nanomicellar agent exhibiting favorable relaxivity for MRI with a good safety profile. MRI reveals an up to two-fold higher contrast enhancement in tumors than in normal muscle. Encapsulating the NIRF dye within the core of the nanoprobe yields an MR/NIRF bimodal imaging agent for tumor detection that is efficient both for MRI, at Gd3+ concentrations 1/10 the standard clinical dose, and for NIRF imaging, allowing over two-fold stronger fluorescence intensities. These self-assembling dendrimer nanosystems thus constitute effective probes for MRI and MR/NIRF multimodality imaging, offering a promising nanotechnology platform for elaborating multimodality imaging probes in biomedical applications. 相似文献
544.
Monique J. Cormier Simon Desmeules Maude St‐Onge Marc Ghannoum 《Hemodialysis international. International Symposium on Home Hemodialysis》2017,21(1):E13-E17
We describe the case of a 52‐year‐old man who presented after having ingested an unknown quantity of phenytoin. Peak phenytoin concentration was 51.2 mg/L (therapeutic range 10–20 mg/L). Five days after admission, the patient became comatose and was intubated. Because of persistent toxic phenytoin levels and unchanged clinical status for 12 days, hemodialysis (HD) was prescribed to enhance elimination of phenytoin. HD was performed using a Gambro TheraliteTM filter (Baxter International Inc., Deerfield, USA), a high cut‐off filter that allows the removal of molecules of up to 45 kDa. Phenytoin concentration readily decreased during the 8‐hour HD treatment from 38.9 mg/L to 27.8 mg/L (28.5% decrease); during HD, phenytoin half‐life was 18.5h (compared to 1109.8h before HD and 56.3h after HD), phentyoin clearance averaged 80.1 mL/min and a total of 1.1 g of phenytoin was removed. Albumin removal from the Theralite filter was most important at the beginning of HD. The high clearance of phenytoin obtained with this filter was likely due to its high surface area rather than its capacity to remove the albumin‐phenytoin complex. 相似文献
545.
Claire Plissonneau Adeline Sivignon Benoit Chassaing Frederic Capel Vincent Martin Monique Etienne Ivan Wawrzyniak Pierre Chausse Frederic Dutheil Guillaume Mairesse Guillaume Chesneau Nathalie Boisseau Nicolas Barnich 《International journal of molecular sciences》2022,23(11)
The Western diet, rich in lipids and in n-6 polyunsaturated fatty acids (PUFAs), favors gut dysbiosis observed in Crohn’s disease (CD). The aim of this study was to assess the effects of rebalancing the n-6/n-3 PUFA ratio in CEABAC10 transgenic mice that mimic CD. Mice in individual cages with running wheels were randomized in three diet groups for 12 weeks: high-fat diet (HFD), HFD + linseed oil (HFD-LS-O) and HFD + extruded linseed (HFD-LS-E). Then, they were orally challenged once with the Adherent-Invasive Escherichia coli (AIEC) LF82 pathobiont. After 12 weeks of diet, total energy intake, body composition, and intestinal permeability were not different between groups. After the AIEC-induced intestinal inflammation, fecal lipocalin-2 concentration was lower at day 6 in n-3 PUFAs supplementation groups (HFD-LS-O and HFD-LS-E) compared to HFD. Analysis of the mucosa-associated microbiota showed that the abundance of Prevotella, Paraprevotella, Ruminococcus, and Clostridiales was higher in the HFD-LS-E group. Butyrate levels were higher in the HFD-LS-E group and correlated with the Firmicutes/Proteobacteria ratio. This study demonstrates that extruded linseed supplementation had a beneficial health effect in a physically active mouse model of CD susceptibility. Additional studies are required to better decipher the matrix influence in the linseed supplementation effect. 相似文献
546.
Milena
l&#x;czkowska Rowida Almomani Margherita Marchi Bianca T. A. de Greef Maurice Sopacua Janneke G. J. Hoeijmakers Patrick Lindsey Erika Salvi Gidon J. Bnhof Dan Ziegler Rayaz A. Malik Stephen G. Waxman Giuseppe Lauria Catharina G. Faber Hubert J. M. Smeets Monique M. Gerrits 《International journal of molecular sciences》2022,23(13)
Neuropathic pain is common in diabetic peripheral neuropathy (DN), probably caused by pathogenic ion channel gene variants. Therefore, we performed molecular inversion probes-next generation sequencing of 5 transient receptor potential cation channels, 8 potassium channels and 2 calcium-activated chloride channel genes in 222 painful- and 304 painless-DN patients. Twelve painful-DN (5.4%) patients showed potentially pathogenic variants (five nonsense/frameshift, seven missense, one out-of-frame deletion) in ANO3 (n = 3), HCN1 (n = 1), KCNK18 (n = 2), TRPA1 (n = 3), TRPM8 (n = 3) and TRPV4 (n = 1) and fourteen painless-DN patients (4.6%—three nonsense/frameshift, nine missense, one out-of-frame deletion) in ANO1 (n = 1), KCNK18 (n = 3), KCNQ3 (n = 1), TRPA1 (n = 2), TRPM8 (n = 1), TRPV1 (n = 3) and TRPV4 (n = 3). Missense variants were present in both conditions, presumably with loss- or gain-of-functions. KCNK18 nonsense/frameshift variants were found in painless/painful-DN, making a causal role in pain less likely. Surprisingly, premature stop-codons with likely nonsense-mediated RNA-decay were more frequent in painful-DN. Although limited in number, painful-DN patients with ion channel gene variants reported higher maximal pain during the night and day. Moreover, painful-DN patients with TRP variants had abnormal thermal thresholds and more severe pain during the night and day. Our results suggest a role of ion channel gene variants in neuropathic pain, but functional validation is required. 相似文献
547.
Monique Janneck Sophie Jent Philip Weber Helge Nissen 《International journal of human-computer interaction》2018,34(11):1052-1062
The workplace is becoming increasingly mobile, as more and more employees regularly work from their home office, spend a lot of time travelling, work on-site at their customers’ place, and use laptops and mobile devices such as smartphones and tablets instead of classical desktop computers. However, while research and checklists on how to create an ergonomic office are readily available, less is known about how the ‘mobile workplace’ should be designed to reduce strains and stress resulting from unfavourable workplace conditions, non-ergonomic equipment or devices, extensive travelling, or work-home interference. In this paper we present the results of an empirical study on the ergonomic requirements of mobile workers. Based on this, we present the ‘Ergonomics Coach’, a prototype of an online coaching application with helpful information and exercises adapted to the mobile workplace. 相似文献
548.
549.
LEIYi MoniqueCalvo-Dahlborg Jean-MarieDubois HEIZukun PatrickWeisbecker DONGChuang 《稀有金属(英文版)》2004,23(1):68-73
A pseudo-ternary alloy system was constructed by combining an icosahedral quasicrystal (IQC), a decagonal quasicrystal(DQC), and Zr into one alloy system. Different proportions of Zr were added to pseudo-binary alloy IQC80DQC20 (mass fraction in %). Structural evolution in these alloys was discussed. An amorphous alloy composition was found in this system and a melt-spinning amorphous alloy was produced in this composition. Through DSC analysis, the amorphous alloy exhibits high glass forming ability comparable to that of the Inoue Zr65Al75Cu17.5Ni10 amorphous alloy. 相似文献
550.