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91.
Sanaz Naghibi Hamid Reza Madaah Hosseini Mohammad Ali Faghihi Sani Mohammad Ali Shokrgozar Morteza Mehrjoo 《Ceramics International》2014
TiO2 nanoparticles (NPs) were synthesized by hydrothermal assisted sol–gel technique. In the next step, as-synthesized NPs were modified by poly ethylene glycol (PEG). Then, folic acid (FA) was conjugated to TiO2–PEG. Finally, Doxorubicin (Dox) as an anticancer drug was loaded on as-prepared TiO2–PEG–FA nanocarrier. The optimization of TiO2 and FA concentration and the influence of ultraviolet (UV) irradiation on photocatalytic activity of nanocarrier and Dox loaded carrier were assessed by utilizing the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT)-assay method. 相似文献
92.
The addition of surfactants to modify the surface property of nanoparticles (NPs) from hydrophilic to hydrophobic also enhances their interfacial properties. Several approaches were previously proposed to calculate the surface tension/interfacial tension (IFT) for different systems in the presence of NPs, surfactants, and electrolytes. However, most of these approaches are indirect and require several measured parameters. Therefore, a mathematical model is developed here to calculate the surface tension/IFT for these systems. The developed model takes into account the cohesive energy due to the interaction of the surfactant CH2 groups, the electric double layer effect due to the interaction among the ions of NPs, surfactants, and electrolytes, and the dipole–dipole interaction of NPs and electrolytes. The developed model is compared and validated with the laboratory experimental data in literature. The results reveal further understanding of the mechanisms involved in stabilization of oil/water emulsion in the presence of NPs, surfactants, and electrolytes. 相似文献
93.
Sorahi Abedinifar Keikhosro Karimi Morteza Khanahmadi Mohammad J. Taherzadeh 《Biomass & bioenergy》2009,33(5):828-833
Rice straw was successfully converted to ethanol by separate enzymatic hydrolysis and fermentation by Mucor indicus, Rhizopus oryzae, and Saccharomyces cerevisiae. The hydrolysis temperature and pH of commercial cellulase and β-glucosidase enzymes were first investigated and their best performance obtained at 45 °C and pH 5.0. The pretreatment of the straw with dilute-acid hydrolysis resulted in 0.72 g g?1 sugar yield during 48 h enzymatic hydrolysis, which was higher than steam-pretreated (0.60 g g?1) and untreated straw (0.46 g g?1). Furthermore, increasing the concentration of the dilute-acid pretreated straw from 20 to 50 and 100 g L?1 resulted in 13% and 16% lower sugar yield, respectively. Anaerobic cultivation of the hydrolyzates with M. indicus resulted in 0.36–0.43 g g?1 ethanol, 0.11–0.17 g g?1 biomass, and 0.04–0.06 g g?1 glycerol, which is comparable with the corresponding yields by S. cerevisiae (0.37–0.45 g g?1 ethanol, 0.04–0.10 g g?1 biomass and 0.05–0.07 glycerol). These two fungi produced no other major metabolite from the straw and completed the cultivation in less than 25 h. However, R. oryzae produced lactic acid as the major by-product with yield of 0.05–0.09 g g?1. This fungus had ethanol, biomass and glycerol yields of 0.33–0.41, 0.06–0.12, and 0.03–0.04 g g?1, respectively. 相似文献
94.
Elham Poonaki Mohammad Esfandyar Hadi Hejazinia Seyed Esmaeil Sadat Ebrahimi Morteza Pirali Hamedani Jafar Farzaneh Mehdi Shafiee Ardestani 《IET nanobiotechnology / IET》2020,14(6):470
Gadolinium as a contrast agent in MRI technique combined with DTPA causes contrast induced nephropathy (CIN) and nephrogenic systemic fibrosis (NSF) which can reduce by usage of antioxidants such as N‐acetyl cysteine by increasing the membrane''s permeability leads to lower cytotoxicity. In this study, N ‐acetyl cysteine‐PLGA Nano‐conjugate was synthesized according to stoichiometric rules of molar ratios andafter assessment by FTIR, NMR spectroscopy and Atomic Force Microscopy (AFM) imaging was combined with Magnevist® (gadopentetate dimeglumine) and its effects on the renal cells were evaluated. MTT [3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide] and cellular uptake assays have indicated relatively significant toxicity of magnevist (P < 0.05) on three cell lines including HEK293, MCF7 and L929 compared to other synthesized ligands that shown no toxicity. Moreover, systemic evaluation has shown no notable changes of blood urea nitrogen (BUN) and creatinine in kidney of mice. In consequence, antioxidant effect was increased as well as the renal toxicity of the contrast agent reduced at the cell level. As a result, PLGA‐NAC nano‐conjugate can be a promising choice for decreasing the magnevist toxicity for treatment and prevention of CIN and will be able to open a new horizon to research on reduction of toxicity of contrast agents by using nanoparticles.Inspec keywords: blood, toxicology, nanofabrication, cellular biophysics, biomedical materials, nanoparticles, chromatography, cancer, biodegradable materials, biomedical MRI, kidney, pH, nanomedicine, patient treatment, diseases, atomic force microscopy, Fourier transform infrared spectraOther keywords: cellular toxicity, gadopentate dimeglumine, contrast agent, magnetic resonance imaging technique, diethylenetriamine pentaacetate, contrast‐induced nephropathy, nephrogenic systemic fibrosis, stoichiometric rules, molar ratios, dimethyl sulphoxide solution, chromatography techniques, nuclear magnetic resonance spectroscopy, atomic force microscopy imaging, Magnevist®, gadopentetate dimeglumine, renal cells, MTT cytotoxicity, human embryonic kidney‐293, L929 cell lines, in vitro conditions, cellular uptake assays, Magnevist uptake, antioxidant effect, renal toxicity, cell level, PLGA nanocarrier, acetylcysteine nanoconjugate, Magnevist toxicity, N‐acetylcysteine–PLGA nano‐conjugate, N‐acetyl cysteine‐poly‐lactic‐co‐glycolic acid nanoconjugate 相似文献
95.
The multi-period multi-product (MPMP) production planning problems, generally, deal with matching production levels of individual products with fluctuated demands over planning horizon. The conventional MPMP optimisation models suffer from insufficient utilisation of available capacity of machines. This fallacy is due to inappropriate formulation of machine capacity and material handling constraints. In this study, a novel mathematical model is proposed to simultaneously optimise production quantities and provide information about managerial decisions such as subcontracting, carrying inventory/backordering, and also hiring/layoff personnel. The problem is then formulated as a mixed integer linear programming (MILP) model by applying appropriate linearisation of non-linear components. The objective is to minimise production costs comprising of production, storage, shortage, subcontracting costs and costs associated with hiring/dismissing labourers. Superiority of the proposed model over existing ones, has been initially evaluated by solving the case presented by Byrne and Bakir [Byrne, M.D. and Bakir, M.A., 1999. Production planning using a hybrid simulation-analytical approach. International Journal of Production Economics, 59 (1), 305–311], and then evaluated by comparing the results obtained from solving both the proposed and the conventional MPMP production planning models using a 100-randomly-generated-test-problem. 相似文献
96.
Farzaneh Khorasani Morteza Mohammadi Zanjireh Mahdi Bahaghighat Qin Xin 《计算机系统科学与工程》2022,40(3):1085-1098
With a sharp increase in the information volume, analyzing and retrieving this vast data volume is much more essential than ever. One of the main techniques that would be beneficial in this regard is called the Clustering method. Clustering aims to classify objects so that all objects within a cluster have similar features while other objects in different clusters are as distinct as possible. One of the most widely used clustering algorithms with the well and approved performance in different applications is the k-means algorithm. The main problem of the k-means algorithm is its performance which can be directly affected by the selection in the primary clusters. Lack of attention to this crucial issue has consequences such as creating empty clusters and decreasing the convergence time. Besides, the selection of appropriate initial seeds can reduce the cluster’s inconsistency. In this paper, we present a new method to determine the initial seeds of the k-mean algorithm to improve the accuracy and decrease the number of iterations of the algorithm. For this purpose, a new method is proposed considering the average distance between objects to determine the initial seeds. Our method attempts to provide a proper tradeoff between the accuracy and speed of the clustering algorithm. The experimental results showed that our proposed approach outperforms the Chithra with 1.7% and 2.1% in terms of clustering accuracy for Wine and Abalone detection data, respectively. Furthermore, achieved results indicate that comparing with the Reverse Nearest Neighbor (RNN) search approach, the proposed method has a higher convergence speed. 相似文献
97.
Bui Hang Thanh Hussain Omar Khadeer Saberi Morteza Hussain Farookh 《World Wide Web》2021,24(2):483-509
World Wide Web - Blockchain, with its ever-increasing maturity and popularity, is being used in many different applied computing domains. To document the advancements made, researchers have... 相似文献
98.
Daniel E. Green Tirumala S. Angara Morteza Nurcheshmeh Thomas Wormald 《The International Journal of Advanced Manufacturing Technology》2012,62(9-12):965-980
In view of the prevalence of non-linear strain paths that develop in parts that are formed in multiple stages, such as bent and hydroformed structural components, the conventional forming limit curve (FLC) cannot be used to assess the forming severity of this manufacturing process. A path-independent stress-based forming limit criterion has been shown to be far more suitable to evaluate such parts, and this paper shows how this failure criterion can be effectively used to evaluate tubular hydroformed parts “on the shop floor”. Knowing the strain history in a given location of a part, a shifted FLC can be computed from the stress-FLC and used to determine the safety margin at this location. This methodology was used to evaluate the forming severity of an automotive instrument panel beam. It was found that this approach is user-friendly and provides a significant improvement in the ability to assess process robustness and product quality compared to the conventional method. The FLCs obtained using the proposed method were found to be in good agreement with those predicted with an MK-based calculation code. Finally, it is shown that a numerical simulation of the entire forming process is recommended to confirm the estimated strain path in critical locations and improve the accuracy of the method. 相似文献
99.
100.