Laparoscopically assisted vaginal hysterectomy

OBJECTIVE: To report our experience with laparoscopically assisted vaginal hysterectomy (LAVH) and evaluate the advantages of LAVH. STUDY DESIGN: From January 1991 to August 1992, 176 LAVHs were performed at the Department of Obstetrics and Gynecology, College of Medicine, Chung-Ang University, Seoul, Korea. The indications for LAVH, based on the preoperative diagnosis, were uterine myomas, dysmenorrhea, chronic pelvic inflammatory disease or pelvic pain, dysfunctional uterine bleeding and cervical intraepithelial neoplasia (in order of frequency). RESULTS: Patients had concomitant procedures, including incidental appendectomy, posterior wall repair, pelvic adhesiolysis and salpingo-oophorectomy. Bipolar forceps were used to compress and desiccate vessels. The Nd-YAG laser, scissors and/or unipolar electrode were used for tissue division, excision of adhesions and cutting. The intraoperative complications were bladder perforation, massive hemorrhage and inferior epigastric vessel injury (one case each). The postoperative complications were infection, voiding difficulty, febrile morbidity, pelvic abscess, incisional hernia, vaginal vault bleeding and peroneal nerve palsy (one case each). CONCLUSION: Hysterectomy can be safely performed vaginally assisted by operative laparoscopy by well-trained laparoscopists, resulting in reduced surgical morbidity, blood loss, postoperative discomfort, recovery time and hospitalization.     

Characteristic Analysis of Interior Permanent-Magnet Synchronous Motor in Electrohydraulic Power Steering Systems

This paper presents design and analysis results of a 2.6-kW interior permanent-magnet synchronous motor developed for an electrohydraulic power steering system. The motor was designed by using the proposed equivalent magnetic circuit model in consideration with a core loss. To analyze motor characteristics by using the equivalent magnetic circuit model, inductance and iron-loss resistance, which are affected critically by magnetic saturation, are obtained by using finite-element analysis. Finally, motor characteristics such as armature current, torque, and efficiency are calculated by the equivalent magnetic circuit model and verified by experimental results.     

Pinostrobin Suppresses the α-Melanocyte-Stimulating Hormone-Induced Melanogenic Signaling Pathway

Pinostrobin is a dietary flavonoid found in several plants that possesses pharmacological properties, such as anti-cancer, anti-virus, antioxidant, anti-ulcer, and anti-aromatase effects. However, it is unclear if pinostrobin exerts anti-melanogenic properties and, if so, what the underlying molecular mechanisms comprise. Therefore, we, in this study, investigated whether pinostrobin inhibits melanin biosynthesis in vitro and in vivo, as well as the potential associated mechanism. Pinostrobin reduced mushroom tyrosinase activity in vitro in a concentration-dependent manner, with an IC₅₀ of 700 μM. Molecular docking simulations further revealed that pinostrobin forms a hydrogen bond, as well as other non-covalent interactions, between the C-type lectin-like fold and polyphenol oxidase chain, rather than the previously known copper-containing catalytic center. Additionally, pinostrobin significantly decreased α-melanocyte-stimulating hormone (α-MSH)-induced extracellular and intracellular melanin production, as well as tyrosinase activity, in B16F10 melanoma cells. More specifically, pinostrobin inhibited the α-MSH-induced melanin biosynthesis signaling pathway by suppressing the cAMP–CREB–MITF axis. In fact, pinostrobin also attenuated pigmentation in α-MSH-stimulated zebrafish larvae without causing cardiotoxicity. The findings suggest that pinostrobin effectively inhibits melanogenesis in vitro and in vivo via regulation of the cAMP–CREB–MITF axis.     

A case study on detection and sizing of defects in steam generator tubes using eddy current testing

Eddy current testing (ECT) method is widely used to detect various types of defects occurring in nuclear steam generator tubes. Therefore, the reliability of its detection and sizing accuracy for defects should be validated. For this purpose, two tubes with defect signals were pulled from an operating steam generator and destructively examined. The defect type was a circumferential crack for one tube and an intergranular attack (IGA) for the other tube. The plus point coil probe showed a better capability to detect and size both a circumferential crack and a volumetric IGA than pancake and bobbin coil probe. The destructive results are correlated with the ECT results obtained during the in-service inspection.     

Theoretical investigation of optical wavelength conversion techniques for DPSK Modulation formats using FWM in SOAs and frequency comb in 10 gb/s transmission systems

We have investigated the wavelength conversion techniques for differential phase-shift keying (DPSK) modulation formats in 10 Gb/s transmission systems, compared with the non-return-to-zero (NRZ) modulation format. For the wavelength conversion of DPSK modulation formats, we employed the wavelength converters based on the four-wave mixing (FWM) in semiconductor optical amplifiers (SOAs) and the frequency comb generated by phase modulation. The power penalty at 10/sup -9/ bit error rate was used as a measure of the system performance degraded by the wavelength conversion. Our simulation results show that the DPSK modulation formats have a smaller power penalty than the NRZ modulation format for the wavelength conversion using the FWM effect in an SOA due to a much lower pattern effect. However, as the wavelength conversion uses the frequency comb generated by phase modulation, it has a similar power penalty compared with the NRZ modulation format. It is also shown that the DPSK modulation formats are possible to obtain the power penalty less than 0.4 dB for both wavelength conversion techniques.     

Enzymatic Hydrolysis of Recovered Protein from Frozen Small Croaker and Functional Properties of Its Hydrolysates

ABSTRACT:  Fish protein isolate were recovered from frozen small croaker using pH shift. The partial enzymatic hydrolysates were fractionated as soluble and insoluble parts. They were dried using the drum dryer and their functional properties were examined. The total nitrogen content of the enzymatic hydrolysates ranged from 12.9% to 13.7%. The degree of hydrolysis of precipitates was 18.2% and 12.2% for croaker hydrolysates treated with Protamex 1.5 MG ( Bacilllus  protease complex) and Flavourzyme 500 MG (endoproteases and exoproteases, Aspergillus oryzae ), respectively. The TCA supernatant, after centrifugation of hydrolysates, contained numerous peptides ranging from 100 to 4000 daltons. The solubility of the supernatants was higher than that of the precipitates at 0% to 3% NaCl and pH 2 to 10. The precipitate of Flavourzyme- and Protamex-treated hydrolysates showed a high emulsion activity index value compared to egg white and bovine plasma protein. In addition, the highest emulsion stability was observed for Protamex-treated precipitate hydrolysates. Emulsion stability of Protamex-treated precipitate hydrolysates was comparable to those of protein additives (egg white, bovine plasma protein, and soy protein concentrate). Water and fat binding capacity of precipitates were higher than those of supernatant. The results indicate that precipitate hydrolysate from undersized croaker can be used in processed muscle foods as a functional and nutritional ingredient.     

Effect of Dietary Red Meat on Colorectal Cancer Risk—A Review

Heme iron overload has been implicated as the main cause of the increased risk of cancer due to the consumption of red meat. However, fish and shellfish, teas, and spices contain up to five times more iron than red meat. There is insufficient evidence that iron intake in dietary red meat is the primary causal factor for colorectal cancer. In addition, harmful substances produced during the preparation of red meat, including heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), N‐nitroso compounds, and acrylamide, are extrinsic factors that increase carcinogenicity. HCAs are produced during the cooking of red meat, poultry meat, and fish. PAHs may also be produced during the cooking of diverse food groups, such as dairy products, fruits, vegetables, and cereals. The average daily intake of red meat among Korean individuals is 62 g; the amount of PAHs entering the body via red meat is less than the average amount of PAHs the body is exposed to in the air. Therefore, it is difficult to conclude that dietary red meat is the main cause of colorectal cancer. Rather, there may be an intricate influence of multiple factors, including fruit and vegetable intake, alcohol consumption, smoking, overweight, obesity, and stress.