TRPA1 Role in Inflammatory Disorders: What Is Known So Far?

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of channels, is primarily localized in a subpopulation of primary sensory neurons of the trigeminal, vagal, and dorsal root ganglia, where its activation mediates neurogenic inflammatory responses. TRPA1 expression in resident tissue cells, inflammatory, and immune cells, through the indirect modulation of a large series of intracellular pathways, orchestrates a range of cellular processes, such as cytokine production, cell differentiation, and cytotoxicity. Therefore, the TRPA1 pathway has been proposed as a protective mechanism to detect and respond to harmful agents in various pathological conditions, including several inflammatory diseases. Specific attention has been paid to TRPA1 contribution to the transition of inflammation and immune responses from an early defensive response to a chronic pathological condition. In this view, TRPA1 antagonists may be regarded as beneficial tools for the treatment of inflammatory conditions.     

Biocompatibility and Mechanical Stability of Nanopatterned Titanium Films on Stainless Steel Vascular Stents

Nanoporous ceramic coatings such as titania are promoted to produce drug-free cardiovascular stents with a low risk of in-stent restenosis (ISR) because of their selectivity towards vascular cell proliferation. The brittle coatings applied on stents are prone to cracking because they are subjected to plastic deformation during implantation. This study aims to overcome this problem by using a unique process without refraining from biocompatibility. Accordingly, a titanium film with 1 µm thickness was deposited on 316 LVM stainless-steel sheets using magnetron sputtering. Then, the samples were anodized to produce nanoporous oxide. The nanoporous oxide was removed by ultrasonication, leaving an approximately 500 nm metallic titanium layer with a nanopatterned surface. XPS studies revealed the presence of a 5 nm-thick TiO₂ surface layer with a trace amount of fluorinated titanium on nanopatterned surfaces. Oxygen plasma treatment of the nanopatterned surface produced an additional 5 nm-thick fluoride-free oxide layer. The samples did not exhibit any cracking or spallation during plastic deformation. Cell viability studies showed that nanopatterned surfaces stimulate endothelial cell proliferation while reducing the proliferation of smooth muscle cells. Plasma treatment further accelerated the proliferation of endothelial cells. Activation of blood platelets did not occur on oxygen plasma-treated, fluoride-free nanopatterned surfaces. The presented surface treatment method can also be applied to other stent materials such as CoCr, nitinol, and orthopedic implants.     

Electrolyte/Structure?Dependent Cocktail Mediation Enabling High?Rate/Low?Plateau Metal Sulfide Anodes for Sodium Storage

As promising anodes for sodium-ion batteries, metal sulfides ubiquitously suffer from low-rate and high-plateau issues, greatly hindering their application in f...     

Recent developments in catalyst synthesis using DBD plasma for reforming applications

The catalyst has a significant role in gas processing applications such as reforming technologies for H₂ and syngas production. The stable catalyst is requisite for any industrial catalysis application to make it commercially viable. Several methods are employed to synthesize the catalysts. However, there is still a challenge to achieve a controlled morphology and pure catalyst which majorly influences the catalytic activity in reforming applications. The conventional methods are expansive, and the removal of the impurities are major challenges. Nevertheless, it is not straightforward to achieve the desired structure and stability. Therefore, significant interest has been developed on the advanced techniques to take control of the physicochemical properties of the catalyst through non-thermal plasma (NTP) techniques. In this review, the systematic evolution of the catalyst synthesis using NTP technique is elucidated. The emerging DBD plasma to synthesized and effective surface treatment is reviewed. DBD plasma synthesized catalyst performance in reforming application for H₂ and syngas production is summarised. Furthermore, the status of DBD plasma for catalyst synthesis and proposed future avenues to design environmentally suitable and cost-effective synthesis techniques are discussed.     

Evaluation of damage to light structures erected on a fill material rich in expansive soil

The paper reports a study of the cause of defects in light structures and the toppling of a wall constructed on a fill material rich in Ankara clay. Laboratory tests were carried out on vertical and horizontal samples from boreholes and a trial pit was excavated near the damaged structures. The results showed that in the vicinity of the toppled wall, swelling pressures in the horizontal direction were greater than those measured in the vertical direction. The swelling properties of the fill material were higher than those of original Ankara clay as determined previously by other investigators, suggesting that breakdown of the cementing bonds and a change in the fabric are the main factors affecting the swelling pressure of disturbed and compacted expansive soils. The calculations to predict uplift showed a good agreement with the observations in the damaged structures. It is concluded that swelling was the main cause of the damage to the light structures at the study site and resulted from the highly expansive nature of the fill material, poor drainage, the semi-arid climate, poor construction methods and ineffective precautions. Some recommendations for minimizing the effects of swelling at the study site are briefly outlined.     

Hierarchical behavior categorization using correlation based adaptive resonance theory

This paper introduces a new model for robot behavior categorization. Correlation based adaptive resonance theory (CobART) networks are integrated hierarchically in order to develop an adequate categorization, and to elicit various behaviors performed by the robot. The proposed model is developed by adding a second layer CobART network which receives first layer CobART network categories as an input, and back-propagates the matching information to the first layer networks. The first layer CobART networks categorize self-behavior data of a robot or an object in the environment while the second layer CobART network categorizes the robot's behavior with respect to its effect on the object. Experiments show that the proposed model generates reasonable categorization of behaviors being tested. Moreover, it can learn different forms of the behaviors, and it can detect the relations between them. In essence, the model has an expandable architecture and it contains reusable parts. The first layer CobART networks can be integrated with other CobART networks for another categorization task. Hence, the model presents a way to reveal all behaviors performed by the robot at the same time.     

Cobalt loaded organic acid modified kaolin clay for the enhanced catalytic activity of hydrogen release via hydrolysis of sodium borohydride

Inorganic acids such as hydrochloric acid (HCl), nitric acid (HNO₃) and sulphuric acid (H₂SO₄) are generally used in the acid modification of clays. Here, CoB catalyst was synthesized on the acetic acid-activated kaolin support material (CH₃COOH -kaolin- CoB) with an alternative approach. This prepared catalyst, firstly, was used to catalyze the hydrolysis of NaBH₄ (NaBH₄-HR). The structure of the raw kaolin, kaolin-CH₃COOH, and CH₃COOH-kaolin-CoB samples were characterized by X-ray diffraction spectroscopy (XRD), Fourier transforms infrared spectroscopy (FTIR), scanning electron microscope (SEM), and nitrogen adsorption. At the same time, this catalyst performance was examined by Co loading, NaBH₄ concentration, NaOH concentration, temperature and reusability parameters. The end times of this hydrolysis reaction using raw kaolin-CoB and CH₃COOH-kaolin-CoB were found to be approximately 140 and 245 min, respectively. The maximum hydrogen generation rates (HGRs) obtained at temperatures 30 °C and 50 °C were 1533 and 3400 mL/min/g_catalyst, respectively. At the same time, the activation energy was found to be 49.41 kJ/mol.