Fibrous myopathy. A rheumatic complication of drug abuse

A progressive fibrous myopathy may result from chronic intramuscular drug abuse. This complication may mimic other rheumatic disorders and early recognition may prevent disability. The patient described here presented with fixed flexion and extension contracture of hips and knees, respectively, after abusing meperidine and other agents for 3 years. Soft tissues of thighs and buttocks were "wood hard," EMG showed absence of action potentials in affected muscles, and biopsy revealed extensive replacement of muscle with dense, acellular fibrous tissue. Possible mechanisms are discussed.     

A combined approach to solve the redundancy optimization problem for multi-state systems under repair policies

This paper combines universal moment generating function technique with stochastic Petri nets to solve the redundancy optimization problem for multi-state systems under repair policies. Redundant elements are included in order to achieve a desirable level of production availability. The elements of the system are characterized by their cost, performance and availability. These elements are chosen from a list of products available on the market. The number of repair teams is less than the number of reparable elements, and a repair policy specifies the maintenance priorities between the system elements. A heuristic is proposed to determine the minimal cost system configuration under availability constraints. This heuristic, first applies universal moment generating function technique to evaluate the system availability, assuming unlimited maintenance resources. Once a preliminary solution is found by the optimization algorithm, stochastic Petri nets are used to model different repair policies, and to find the best system configuration (architecture and number of repairmen) in terms of global performance (availability and cost). This combined procedure is applied to a reference example.     

Healthcare knowledge sharing among a community of specialized physicians

Healthcare organizations strive to make the best use of their organizational knowledge. The collective know-hows of the medical workers directly affect the quality of the delivered healthcare services. This study addresses the healthcare knowledge-sharing among a community of specialized physicians. An extensive study of the literature on knowledge-sharing in industries generally and healthcare organizations specifically were presented. Six focal elements were detected in previous attempts to address the knowledge-sharing status in healthcare organizations. Additionally, three previous models for healthcare knowledge management were analyzed. The studied literature along with the three studied models helped in constructing the framework and suggesting a suitable research methodology for primary data collection. Qualitative approach of in-depth interview technique was used for interviewing eight specialized physicians. The data collected from the interviewees were then analyzed and produced explanatory themes and codes. These themes are physicians’ acquisition of medical knowledge, staff participating in the knowledge sharing, knowledge-sharing culture, ICT-based knowledge sharing and top management involvement. The findings resulted in recognizing four considerations which ought to be taken into account for successful knowledge-sharing activities and learning initiatives in the healthcare organization. Conclusions and recommendations for future studies were presented based on the implications of this research study.     

梳齿的不平行对电容式微机械传感器阶跃信号响应的影响

分析了梳齿电容式传感器在三种电容驱动方式下,梳齿电容极板的不平行对传感器受到阶跃加速度信号作用时可靠工作条件的影响。得到了梳齿倾斜效应对传感器阶跃加速度响应影响的分析模型。结果表明梳齿电容在同样的电压驱动下,若电容极板的倾斜角变到0.5°时,对于单边电容结构、双边电容结构和有力反馈的双边电容结构,传感器能够承受的临界阶跃加速度分别变为电容极板完全平行时的0.34、0.44、0.52。并针对DRIE工艺刻蚀梳齿的原理,讨论了改进梳齿不平行的方法。     

Polyphenol-rich seaweed (Eucheuma cottonii) extract suppresses breast tumour via hormone modulation and apoptosis induction

The edible red seaweed Eucheuma cottonii is abundantly cultivated for carrageenan production. This study investigated the effects of dietary E. cottonii polyphenol-rich extract (ECME) on breast cancer. In vitro assays showed that ECME was antiproliferative against oestrogen-dependent MCF-7 and oestrogen-independent MB-MDA-231 human breast-cancer cells (IC₅₀ values of 20 and 42 μg/ml, respectively) but was non-toxic to normal cell lines. The ECME (150 and 300 mg/kg BW) was fed to female rats and, after 4 weeks, rat mammary tumour was induced using LA7 cells (inoculated subcutaneously). The ECME inhibited tumour development and erythrocyte lipid peroxidation in the cancer-induced rats, dose-dependently. It showed anti-oestrogenic effects on the rat estrous cycle and serum hormone levels. Electron microscopy and histopathology observations confirmed apoptosis in the rat mammary tumours. The polyphenol-rich ECME was tumour-suppressive via apoptosis induction, downregulating the endogenous oestrogen biosynthesis, and improving antioxidative status in the rats.     

Establishing a limit of recognition for a vapor sensor array

Organic vapor analysis with microsensor arrays relies principally on two output parameters: the response pattern, which provides qualitative information, and the response sensitivity, which determines the limit of detection (LOD). The latter is used to define the operating limit in the low-concentration range, under the implicit assumption that, if a vapor can be detected, it can be identified and differentiated from other vapors on the basis of its response pattern. In this study, the performance of an array of four polymer-coated surface acoustic wave vapor sensors was explored using calibrated response data from 16 solvent vapors in Monte Carlo simulations coupled with pattern recognition analysis. The statistical modeling revealed that the ability to recognize a vapor from its response pattern decreases with decreasing vapor concentration, as expected, but also that the concentration at which errors in vapor recognition become excessive is well above the calculated LOD in most cases, despite the LOD being based on the least sensitive sensor in the array. These results suggest the adoption of a limit of recognition (LOR), defined as the concentration below which a vapor can no longer be reliably recognized from its response pattern, as an additional criterion for evaluating the performance of multisensor arrays. A generalized method for estimating the LOR is presented, as well as a means for improving the LOR via residual error analysis.     

Human–robot interaction in industrial collaborative robotics: a literature review of the decade 2008–2017

ABSTRACT

Currently, a large number of industrial robots have been deployed to replace or assist humans to perform various repetitive and dangerous manufacturing tasks. However, based on current technological capabilities, such robotics field is rapidly evolving so that humans are not only sharing the same workspace with robots, but also are using robots as useful assistants. Consequently, due to this new type of emerging robotic systems, industrial collaborative robots or cobots, human and robot co-workers have been able to work side-by-side as collaborators to accomplish tasks in industrial environments. Therefore, new human–robot interaction systems have been developed for such systems to be able to utilize the capabilities of both humans and robots. Accordingly, this article presents a literature review of major recent works on human–robot interactions in industrial collaborative robots, conducted during the last decade (between 2008 and 2017). Additionally, the article proposes a tentative classification of the content of these works into several categories and sub-categories. Finally, this paper addresses some challenges of industrial collaborative robotics and explores future research issues.     

A Black-oil Three-phase Model With Capillary Effects

Abstract

The black-oil (BO) model for compositional effect in three-phase compressible flow with capillary pressure is discussed. The compositional framework is used in modeling of a BO that allows extending a BO model to a compositional model and vice versa. A total compressibility condition is defined for saturated and unsaturated cases when the capillary effects are not ignored.