Overexpression of amyloid precursor protein of Alzheimer's type in brains of intoxicated children

The coincidence of neuronal stress induced by intoxication and an overexpression of amyloid precursor protein (APP) in the brains of children was examined. Brains of ten children accidentally intoxicated by poisonous mushroom were studied by means of immunohistochemical methods using monoclonal antibodies generated against different domains of APP and glial cell markers. Overexpression of APP was found in the brain neurons of all intoxicated children. Neurons were immunopositive with the antibodies generated against the middle (amyloid beta protein) domain of APP. No extracellular deposits were found in the tissue. Our results provided, for the first time, the evidence that overexpression of APP concomitant with the neuronal stress is age-independent phenomenon appearing not only in the brain of adults but in very young individuals as well.     

Direct electrooxidation of methanol on highly dispersed platinum-based catalyst electrodes: temperature effect

The direct electrooxidation of methanol in acid medium was studied on electrodes made of a perfluorinated membrane with small amounts of metal catalysts incorporated by chemical reduction. Platinum is a good electrocatalyst for this reaction, but needs to be modified by other metals in order to obtain oxidation potentials much more compatible with a working anode in a direct methanol fuel cell. Ruthenium and tin appear to give encouraging results, leading to a negative shift of more than 250 mV as compared to the potential obtained with pure platinum. Other parameters were investigated in this work, such as the working temperature, and the manner of introduction of the methanol into the cell. By gaseous supply, it was possible to carry out measurements at higher temperatures than with methanol in solution, and consequently to greatly improve the performance of the catalytic electrode.     

Estimation of collapse moment for the wall-thinned pipe bends using fuzzy model identification

In this work, the collapse moment due to wall-thinned defects is estimated through fuzzy model identification. A subtractive clustering method is used as the basis of a fast and robust algorithm for identifying the fuzzy model. The fuzzy model is optimized by a genetic algorithm combined with a least squares method. The developed fuzzy model has been applied to the numerical data obtained from the finite element analysis. Principal component analysis is used to preprocess the input signals into the fuzzy model to reduce the sensitivity to the input change and the fuzzy model are trained by using the data set prepared for training (training data) and verified by using another data set different (independent) from the training data. Also, three fuzzy models are trained, respectively, for three data sets divided into the three classes of extrados, intrados, and crown defects, which is because they have different characteristics. The relative root mean square (RMS) errors of the estimated collapse moment are 0.5397% for the training data and 0.8673% for the test data. It is known from this result that the fuzzy models are sufficiently accurate to be used in the integrity evaluation of wall-thinned pipe bends and elbows.     

ZrO_2与40Cr钢钎焊中的缓冲层

本试验研究了ＺｒＯ２与４０Ｃｒ钢在加入缓冲层前后的钎焊连接，结果表明：插入缓冲层Ｃｕ和Ｔｉ可以提高接头强度。对每一种缓冲层，存在一最佳厚度，对应的钎焊强度最大。此最佳厚度对Ｃｕ为０．４ｍｍ左右，对Ｔｉ为１ｍｍ左右。作者认为这是由缓冲层的力学性能和热膨胀系数对残余应力释放产生的两种相反影响而造成的。钎焊时，缓冲层Ｃｕ和Ｔｉ向钎料中均有程度不同的溶解，但不影响钎料对ＺｒＯ２的浸润和反应结合。ＺｒＯ２－４０Ｃｒ钢连接的所有接头均断在陶瓷的近缝区，其断裂方式有三种。     

陕北姬塬油区储集层特征地球物理测井分析

为了保持油井稳产，提高油藏采收率，姬塬油区拟采用面积法注水，急需对油藏分布规律进行详实、系统的研究，以保证井网建设的合理、高效。在前人研究成果基础上，对油区现有测井资料进行收集、整理、再解释，从油藏特征研究出发，对储集层进行测井分析，并使用克里金技术进行了地质建模。使用容积法计算油藏储量，为油区的注水开发提供了油藏资料。     

溶胶-凝胶法制备(Sr,Pb)TiO3纳米晶粉及表征

采用溶胶－凝胶法成功地合成了（Sr,Pb)TiO3纳米晶粉，并利用FTIR技术对凝胶的形成过程及350℃，1．5h煅烧获得的粉体材料进行了表征。实验以TG－DSC分析作为拟定煅烧温度的依据，以XRD作为煅烧产物的分析手段，最佳煅烧温度为600℃，所合成的（Sr,Pb)TiO3纳米晶粉的平均晶粒尺寸约为21nm，属钙钛矿型立方顺电相结构。     

在周期反复荷载下加固后内框架与砖墙的抗震性能

通过对采用外加钢筋混凝土壁柱加固的三层内框架和采用外加构造柱加固的三层开洞砖墙模型的试验研究,探讨了在垂直荷载及往复水平力共同作用下这类结构的抗震性能和破坏机理。获得了加固结构模型的侧向抗力与变形的滞回曲线及该模型在弹性、弹塑性与破坏三个阶段的变形规律和抗力的骨架曲线。 依据对试验结果的分析,得出了多层内框架房屋采用外加钢筋混凝土壁柱加固内框架与采用外加构造柱加固砖墙的抗震设计计算方法。     

低渗透压敏油藏油井流入动态方程及其应用

注水开发的低渗透油藏存在启动压力和压力敏感性,使开发难度加大。当流压低于饱和压力以后,流入动态指示曲线凹向压力轴,会出现一个产量最大点。在前人研究的基础上,从平面径向拟稳态渗流规律出发,考虑启动压力梯度和压力敏感效应对油藏渗流的影响,与油相和液相相对流动能力方程相结合,建立了具有最大产量点的低渗透压力敏感油藏直井流入动态方程,据此可对油藏产能进行评价预测,确定出油井最低允许流动压力和油井的合理工作制度。在龙南、新站油田的应用表明,预测值与实测值比较吻合,满足矿场工程精度要求,说明所建立的流入动态方程能有效评价预测油井产能和确定油井允许的最小流压界限,为充分发挥油井生产能力、合理高效开发低渗透压力敏感油藏提供了理论依据。     

Design of a performance enhanced traceback algorithm for theViterbi decoder

The authors propose an efficient traceback scheme for the parallel hardware implementation of the Viterbi algorithm. Compared to the conventional Viterbi algorithm, where output is selected arbitrarily when multiple survivor paths exist, the proposed algorithm decides decoding output by analysing the survivor paths of consecutive tracebacks. Experimental results show that the proposed algorithm exhibits improved error-correction capability compared to the existing algorithms     

Optimal design of hybrid laminated composite plates with dynamic and static constraints

Optimization procedures are presented that consider the static and dynamic characteristic constraints for laminated composite plates and hybrid laminated composite plates subject to a concentrated load on the center of the plate. The design variables adopted are ply angle or ply thickness. Considered constraints are deflection, natural frequency and specific damping capacity. Using a recursive linear programming method, nonlinear optimization problems are solved, and by introducing the design scaling factor, the number of iterations is reduced significantly. Relating interactive optimization procedures with the finite element method analysis, various hybrid composite plates with arbitrary boundary conditions can be designed optimally. In the optimization procedure, verification of analysis and design of the laminated composite plates are compared with a previous paper. Various design results are presented on laminated composite plates and hybrid laminated composite plates.