The impact of biophilic design in Maggie’s Centres: A meta-synthesis analysis

This paper presents a meta-synthesis conducted to identify, compare and synthesize published qualitative data related to the Maggie's Centres, as a paradigmatic architectural example in the provision of non-institutional cancer support. These centres are internationally renowned for their unique architecture, where the careful design of indoors and outdoors spaces plays a critical role in their agenda for supporting care. Previous research has thoroughly analysed this approach to therapeutic environments, not only confirming the importance of designed space as originally conceived in Maggie's philosophy but also identifying precise supporting effects associated with specific elements within their design. This paper aims to provide a new reading of Maggie's contribution to cancer support by offering an examination of all these data through the lens of biophilia, which clarifies the impact of design decisions connected to nature on cancer patients' lives. The analytic process included a systematic search strategy, extraction and classification of salient concepts using an open-coding approach, and lastly an interpretive evaluation. The systematically selected data helped to identify and rank the biophilic design parameters that appear the most critical for promoting and supporting human health and wellbeing in non-clinical therapeutic environments, from the user's perspective. It also provided a compilation of distinctive design interventions related to biophilic parameters, which provides benchmark information for future research and design guidance in these environments.     

Investigation of the Antiviral Effects of Saussurea lappa Root Extract against SARS-CoV-2 Virus

Scope

The purpose of this study was to look into the antiviral activity of a plant extract derived from the roots of the Saussurea lappa as a food supplement against SARS-CoV-2 infection.

Methods and results

Vero E6 cells are employed in the study to test the neutralizing effect of Saussurea lappa extract against the SARS-CoV-2 virus. For anti-viral activity detection, a sensitive real-time cell analyzer (xCELLigence RTCA) with a high repetition rate is used. A challenge experiment in mice is planned as a result of the in vitro analysis. A challenge test against SARS-CoV-2 is performed with 10 adult female K18-hACE2 transgenic mice in each group for this purpose. The mice in the S. lappa Group are gavaged 2 days before the virus is administered intranasally (i.n.). The control group received PBS instead of the extract. SARS-CoV-2 virus is administered i.n. under anesthesia for the first 3 days of the experiment, and S. lappa extract was administered by gavage in the afternoon. On the 10th day, mice in the S. lappa group survived the study, whereas animals in the control group grew ill and/or died. In this study, the extract protects the mice against the SARS-CoV-2 virus in 90% of the cases.

Conclusions

This study demonstrates that the Saussurea plant has antiviral effects against SARS-CoV-2 in vitro and in animal models.