The Discovery of Aurora Kinase Inhibitor by Multi-Docking-Based Virtual Screening

We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 μM) against aurora kinase. Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase.     

Effects of atomic size difference and heat of mixing parameters on the local structure of a model metallic glass system

Atomic size differences between constituting elements and the heat of mixing are key factors in designing a metallic glass system. In this study, the effects of atomic size differences and the heat of mixing on the glass-forming ability and the local structure of metallic glasses were studied via molecular dynamic simulations of an ideal system known as the Lennard-Jones embedded-atom method model. The atomic size difference and the heat of mixing of the system were varied by means of the Lennard-Jones parameters. The glass transition behavior was characterized based on the chemical short-range order and by a Voronoi analysis. Our simulations lead to optimized windows of atomic size differences and heat of mixing parameters for metallic glass-forming of the model system. Both a greater negative heat of mixing and a larger atomic size difference are necessary for the enhancement of the glass-forming ability.     

Spatial-temporal graph neural network for traffic forecasting: An overview and open research issues

Applied Intelligence - Traffic forecasting plays an important role of modern Intelligent Transportation Systems (ITS). With the recent rapid advancement in deep learning, graph neural networks...     

Recent Progress of Fiber Shaped Lighting Devices for Smart Display Applications—A Fibertronic Perspective

Advances in material science and nanotechnology have fostered the miniaturization of devices. Over the past two decades, the form-factor of these devices has evolved from 3D rigid, volumetric devices through 2D film-based flexible electronics, finally to 1D fiber electronics (fibertronics). In this regard, fibertronic strategies toward wearable applications (e.g., electronic textiles (e-textiles)) have attracted considerable attention thanks to their capability to impart various functions into textiles with retaining textiles' intrinsic properties as well as imperceptible irritation by foreign matters. In recent years, extensive research has been carried out to develop various functional devices in the fiber form. Among various features, lighting and display features are the highly desirable functions in wearable electronics. This article discusses the recent progress of materials, architectural designs, and new fabrication technologies of fiber-shaped lighting devices and the current challenges corresponding to each device's operating mechanism. Moreover, opportunities and applications that the revolutionary convergence between the state-of-the-art fibertronic technology and age-long textile industry will bring in the future are also discussed.     

FeO0.7F1.3/C Nanocomposite as a High‐Capacity Cathode Material for Sodium‐Ion Batteries

Searching high capacity cathode materials is one of the most important fields of the research and development of sodium‐ion batteries (SIBs). Here, we report a FeO_0.7F_1.3/C nanocomposite synthesized via a solution process as a new cathode material for SIBs. This material exhibits a high initial discharge capacity of 496 mAh g^?1 in a sodium cell at 50 °C. From the 3^rd to 50^th cycle, the capacity fading is only 0.14% per cycle (from 388 mAh g^?1 at 3^rd the cycle to 360 mAh g^?1 at the 50^th cycle), demonstrating superior cyclability. A high energy density of 650 Wh kg^?1 is obtained at the material level. The reaction mechanism studies of FeO_0.7F_1.3/C with sodium show a hybridized mechanism of both intercalation and conversion reaction.     

Performance Analysis of Full-Duplex Vehicle-to-Vehicle Relay System over Double-Rayleigh Fading Channels

Mobile Networks and Applications - In this paper, we study the performance of a full-duplex (FD) relay system in vehicle-to-vehicle (V2V) communication. In this relay communication system, the...     

Leaf-to-Whole Plant Spread Bioassay for Pepper and Ralstonia solanacearum Interaction Determines Inheritance of Resistance to Bacterial Wilt for Further Breeding

Bacterial wilt (BW) disease from Ralstonia solanacearum is a serious disease and causes severe yield losses in chili peppers worldwide. Resistant cultivar breeding is the most effective in controlling BW. Thus, a simple and reliable evaluation method is required to assess disease severity and to investigate the inheritance of resistance for further breeding programs. Here, we developed a reliable leaf-to-whole plant spread bioassay for evaluating BW disease and then, using this, determined the inheritance of resistance to R. solanacearum in peppers. Capsicum annuum ‘MC4′ displayed a completely resistant response with fewer disease symptoms, a low level of bacterial cell growth, and significant up-regulations of defense genes in infected leaves compared to those in susceptible ‘Subicho’. We also observed the spreading of wilt symptoms from the leaves to the whole susceptible plant, which denotes the normal BW wilt symptoms, similar to the drenching method. Through this, we optimized the evaluation method of the resistance to BW. Additionally, we performed genetic analysis for resistance inheritance. The parents, F₁ and 90 F₂ progenies, were evaluated, and the two major complementary genes involved in the BW resistance trait were confirmed. These could provide an accurate evaluation to improve resistant pepper breeding efficiency against BW.     

Cache-aided full-duplex: delivery time analysis and optimization

Edge caching has received much attention as a promising technique to overcome the stringent latency and data-hungry challenges in the future generation wireless networks. Meanwhile, full-duplex (FD) transmission can potentially double the spectral efficiency by allowing a node to receive and transmit at the same frequency band simultaneously. In this paper, we investigate the delivery time performance of a cache-aided FD system, in which an edge node, operates in FD mode, serves users via wireless channels and is equipped with a cache memory. Firstly, we derive a closed-form expression for the average delivery time by taking into account the uncertainties of both backhaul and access wireless channels. The derived analysis allows the examination of the impact of key parameters, e.g., cache size and transmit power. Secondly, a power optimization problem is formulated to minimize the average delivery time. To deal with the non-convexity of the formulated problem, we propose an iterative optimization algorithm based on the bisection method. Finally, numerical results are presented to demonstrate the effectiveness of the proposed algorithm. A significant delivery time reduction is achieved by the proposed optimization compared to the FD reference and half-duplex counterpart.

     

Silver metallization for microwave device using aerosol deposition

We examined the possibility of using aerosol deposition (AD) as a simple, environmentally friendly and dry metallization process capable of acting as an alternative to the electroless and electroplating methods. Silver thick films were fabricated, their characteristics evaluated, and the factors influencing their growth investigated. As a result, silver thick films were successfully fabricated by AD with high deposition rates (10 μm/min) at room temperature. The resistivity of the as-deposited silver thick films was 8–10 times larger than that of the bulk silver. Post-annealing increased the resistivity of the silver films by approximately 2–3 times compared to that of the bulk silver. Microstructural observations revealed an increase in the connectivity between the silver particles after the heat treatments, which reduced the resistivity of the as-deposited silver films.