A novel FET model including an illumination intensity parameter forsimulation of optically controlled millimeter-wave oscillators

This paper demonstrates an illuminated FET model including an illumination-intensity parameter for simulation of optical characteristics of microwave and millimeter wave integrated circuits (MMIC's). Modeling for an illuminated GaAs MESFET and an InP high electron-mobility transistor (HEMT), and analysis and experimental results from optically controlled microwave and millimeter-wave hybrid integrated circuit (HIC) and MMIC oscillators are discussed. The proposed illuminated FET model was able to explain the photoresponse of both the GaAs MESFET and the InP HEMT, and the photooperation of their circuits     

Gyrotron Backward Wave Oscillator Experiments with a Relativistic Electron Beam Using an X-Band Rectangular Waveguide

A mildly relativistic electron beam (500keV, 200A, 10ns) injected into an X-band rectangular waveguide immersed in a uniform axial magnetic field (4-10kG) produced magnetically tunable microwave radiation in the 9-13 GHz frequency range with an estimated output power of 1MW. The frequency range and tunability of the radiated microwave agreed with a theoretical model for a gyrotron backward wave oscillator taking into account the low energy component of the beam electron.     

Wavelength tuning of the stimulated emission from GaAs and CdSe electron-beam-pumped lasers

The wavelength at which the stimulated output from a number of electron-beam-pumped semiconductor lasers peaks is a function of the time after the start of the pumping pulse. In general, the output intensity reaches a maximum at short wavelengths considerably before it peaks at the longest. Detailed observations of the wavelength shifts of the peak output as a function of both time and pumping current are reported here for both CdSe and GaAs laser crystals. It is found that the rate of shifting of the wavelength peak (tuning rate) as a function of electron-beam pumping current is very similar in both functional form and magnitude in the two materials. Furthermore, the behavior of the tuning rate is dependent on whether or not lasing action occurs in the crystal under examination. For a crystal in which lasing action is obtained, the tuning rate saturates for pumping current densities above threshold. In contrast, for a nonlasing crystal, the tuning rate is a linearly increasing function of the pumping current density. The implications of these results are discussed with reference to previously reported work concerning shifts with respect to the band edge of the stimulated emission from semiconductor lasers.     

0.13-μm 32-Mb/64-Mb embedded DRAM core with high efficientredundancy and enhanced testability

This paper describes the 32-Mb and the 64-Mb embedded DRAM core with high efficient redundancy, which is fabricated using 0.13-μm triple-well 4-level Cu embedded DRAM technology. Core size of 18.9 mm ² and cell efficiency of 51.3% for the 32-Mb capacity, and core size of 33.4 mm² and cell efficiency of 58.1% for the 64-Mb capacity are realized. This core can achieve 230-MHz burst access at 1.0-V power-supply condition by adopting a new data bus architecture: merged shift column redundancy. We implemented four test functions to improve the testability of the embedded DRAM core. It realizes the DRAM core test in a logic test environment     

Osteoclasts are present in gp130-deficient mice

Interleukin (IL)-6, IL-11, leukemia inhibitory factor, and oncostatin M similarly induce osteoclast formation in cocultures of osteoblastic cells and bone marrow cells. These cytokines share a common signal transducer, gp130, which forms a receptor complex with the specific receptor for each cytokine. To investigate the role of gp130 in osteoclast development, we examined bone tissues in gp130-deficient and wild-type newborn mice of the ICR background. Soft x-ray radiographs and microfocus x-ray computed tomographs revealed that bone marrow cavities were present in tibiae and radii of both wild-type and gp130-deficient mice. Microfocus x-ray computed tomography and histological examination demonstrated a decrease in the amount of trabeculae at the metaphysial region in tibiae and radii of the gp130-deficient mice compared with the wild-type mice. The number ofosteoclasts in gp130-deficient mice was about double that in the wild-type mice. There were no apparent differences in the distributions of alkaline phosphatase-positive osteoblasts and the osteoid surface on the trabecular bone at the metaphysial region between the wild-type and gp130-deficient mice. The volume of mineralized trabecular bones was also decreased at mandibulae, accompanied by the increased number of osteoclasts in gp130-deficient mice compared with the wild-type and heterozygous mice. These results suggest that the formation of osteoclasts is not solely dependent on gp130 signaling, at least during fetal development. The osteoclastic bone resorption in gp130-deficient mice may be caused by the functional redundancy of bone-resorbing hormones and cytokines other than those of the IL-6 family.     

New star coupler compatible with single multimode-fibre data links

A star coupler for optical data links for use with a single multimode fibre, as opposed to fibre bundles, was realised in the form of a multiport directional coupler assembled from bicorical tapers of multimode fibres. The insertion loss above furcation loss of the 4-paired-port coupler was measured to be 2.8 dB.     

Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer

Deregulated inhibition of apoptosis (programmed cell death) may facilitate the insurgence of neoplasia, but whether it also influences the outcome of common cancers has remained controversial. In this study, we investigated the expression of a novel inhibitor of apoptosis, survivin, in colorectal cancer and its relationship with tumor cell apoptosis and overall prognosis. By immunohistochemistry, survivin was expressed in 91 of 171 (53.2%) cases of colorectal carcinomas of histological stages 0 to IV. In contrast, normal colon epithelium did not express survivin. Although survivin expression did not correlate with p53 abnormalities (46.5% versus 58.0%; P = 0.18), survivin-positive cases were strongly associated with bcl-2 expression (72.5% versus 27.4%; P < 0.0001) and reduced apoptotic index (0.76% +/- 0.39% versus 1.17% +/- 0.62%; P < 0.0001). Expression of survivin alone in bcl-2-negative (discordant) cases also resulted in reduced apoptotic index (0.82% +/- 0.57% versus 1.16% +/- 0.66%; P = 0.0046). When analyzed for prognostic significance, patients with low apoptotic index (< 0.97%) had worse survival rates than the group with high apoptosis (P < 0.001), and a multivariate Cox proportional hazard model identified reduced apoptosis as an independent predictive factor for overall survival (P < 0.0001). These data demonstrate that apoptosis inhibition by survivin, alone or in cooperation with bcl-2, is an important predictive/prognostic parameter of poor outcome in colorectal carcinoma and identify survivin as a new diagnostic/therapeutic target in cancer.