Polyurethane‐incorporated chitosan/alginate core–shell nano‐particles for controlled oral insulin delivery

Chitosan (CS) and polyurethane‐chitosan (PU‐CS) nano‐particles (NPs) were prepared for the core formation by complex coacervation method whereas alginate (ALG) and PU‐ALG were crosslinked by ionic gelation method to form the protective shell‐layer over the core. Effects of PU incorporation either within the core or shell or both were investigated by different in vitro and in vivo parameters. Fourier transform infrared (FTIR) spectroscopy of different compositions of nano‐particles showed distinct characteristic peaks for CS, PU, and ALG, indicating their presence in variable ratios. Significance of polyurethane‐incorporated systems towards insulin encapsulation efficiency, swelling parameters, insulin release, and in vivo pharmacological effect were also studied. Particle sizes, zeta potential, morphological analysis, mucoadhesion study, and in vivo acute toxicity studies of these core–shell nano‐particles were also performed. Bioavailability of insulin ranged from 9.04% to 11.6% for polyurethane‐incorporated chitosan‐alginate core–shell nano‐particle formulations which was significantly higher than the insulin bioavailability of basic CS/ALG core–shell nano‐particle system. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135, 46365.     

Evaluation of nonlinear static analysis methods and software tools for seismic analysis of highway bridges

The response of bridges when subjected to seismic excitation can be evaluated by a number of analysis methods. The traditional approach is to employ linear static or dynamic analyses coupled with appropriate modifiers to account for inelastic response while current design practice is moving towards an increased emphasis on nonlinear static analysis methods. In this study, a preliminary seismic response analysis of a two-span highway bridge was performed using linear dynamic analysis procedures to identify the potential for inelastic response. The bridge was subsequently analyzed in accordance with two nonlinear static analysis methods (capacity spectrum and inelastic demand spectrum methods) in an effort to evaluate the difference in global response predicted by the two methods and the effectiveness of various software programs for performing nonlinear static analysis. The results demonstrated that, for the two nonlinear static analysis methods used in this study, different predictions of nonlinear response occurred with neither method being regarded as producing correct results due to a number of simplifications inherent in the methods. Furthermore, the analysis revealed that some software programs are well suited to performing nonlinear static analysis, both from the point-of-view of performing comprehensive analyses and providing a graphical depiction of the evolution of damage (i.e. the behaviour of plastic hinges).     

Novel algebraic meal disturbance estimation based adaptive robust control design for blood glucose regulation in type 1 diabetes patients

This study designs a robust closed‐loop control algorithm for elevated blood glucose level stabilisation in type 1 diabetic patients. The control algorithm is based on a novel control action resulting from integrating algebraic meal disturbance estimator with back‐stepping integral sliding mode control (BISMC) technique. The estimator shows finite time convergence leading to accurate and fast estimation of meal disturbance. Moreover, compensation of the estimated disturbance in controller provides significant reduction in chattering phenomenon, which is inherent drawback of sliding mode control (SMC). The controller is applied to one of the most reliable models of type 1 diabetic patients, named Bergman''s minimal model. The effectiveness and superiority of the designed controller is shown by comparing it to classical SMC and super‐twisting sliding mode control. The designed controller is subject to three different cases for detailed analysis of the controller''s robustness against meal disturbance. The three cases considered are hyperglycaemia, hyperglycaemia combined with meal disturbance and three meal disturbance. The simulation results confirm superior performance of algebraic disturbance estimator based BISMC controller for all the cases mentioned above.Inspec keywords: closed loop systems, robust control, sugar, medical control systems, variable structure systems, control system synthesis, blood, nonlinear control systems, adaptive control, diseasesOther keywords: adaptive robust control design, blood glucose regulation, type 1 diabetes patients, closed‐loop control algorithm, elevated blood glucose level stabilisation, type 1 diabetic patients, novel control action, algebraic meal disturbance estimator, mode control technique, accurate estimation, estimated disturbance, super‐twisting sliding mode control, algebraic disturbance estimator, BISMC controller, algebraic meal disturbance estimation, back‐stepping integral sliding mode control technique     

A Novel Compact Highly Isolated UWB MIMO Antenna with WLAN Notch

This paper presents a compact Multiple Input Multiple Output (MIMO) antenna with WLAN band notch for Ultra-Wideband (UWB) applications. The antenna is designed on 0.8 mm thick low-cost FR-4 substrate having a compact size of 22 mm × 30 mm. The proposed antenna comprises of two monopole patches on the top layer of substrate while having a shared ground on its bottom layer. The mutual coupling between adjacent patches has been reduced by using a novel stub with shared ground structure. The stub consists of complementary rectangular slots that disturb the surface current direction and thus result in reducing mutual coupling between two ports. A slot is etched in the radiating patch for WLAN band notch. The slot is used to suppress frequencies ranging from 5.1 to 5.9 GHz. The results show that the proposed antenna has a very good impedance bandwidth of |S11| < −10 dB within the frequency band from 3.1–14 GHz. A low mutual coupling of less than −23 dB is achieved within the entire UWB band. Furthermore, the antenna has a peak gain of 5.8 dB, low ECC < 0.002 and high Diversity Gain (DG > 9.98).     

Silatrane based imide resins: synthesis and characterization

A series of silatrane based imide resins having different end-caps were prepared by reacting 1-(3-aminopropyl)silatrane with 5-norbornene-endo-2,3-dicarboxylic anhydride (nadic anhydride), 5-methyl-5-norbornene-2,3-dicarboxylic anhydride (methyl nadic anhydride), hexachloronadic anhydride, maleic anhydride, benzophenone-3,3′,4,4′-tetracarboxylic dianhydride or pyromellitic dianhydride in dimethylacetamide. Structural characterisation of the resins was done by elemental analysis and IR. In DSC traces of these resins, an exothermic transition associated with crosslinking was observed above 230°C. Thermogravimetric studies revealed a multistep decomposition reaction. Residual weight at 800°C in nitrogen was found to depend on the backbone structure and ranged from 32–60%.     

A residential end-use energy consumption model for Canada

The residential sector is the third largest end-use energy consumer in Canada. With the increasing pressure on Canada to reduce its energy consumption and the associated carbon dioxide emissions, reducing energy consumption in the residential sector is very important. To quantitatively assess the impact of the large number of measures that can be adopted to reduce the residential energy consumption, a residential energy model for Canada (Canadian Residential Energy End-use Model—CREEM) was developed. This paper presents the model, the characteristics of the residential energy consumption in Canada, and impact of various energy consumption reduction scenarios. © 1998 John Wiley & Sons, Ltd.     

Optimization of background suppression for arterial spin labeling perfusion imaging

Object  

To present an algorithm for optimization of background suppression pulse timing for arterial spin labeling (ASL) perfusion imaging.     

Genetics of colorectal and breast cancer

Colorectal and breast cancers account for a significant number of deaths due to malignant neoplasia. Laboratory medicine plays an important role in the diagnosis and management of these tumors through the application of histopathology, immunohistochemistry, and serologic identification of tumor markers. Approximately 5% to 10% of colorectal and breast cancers result from an inherited predisposition. The genes responsible for most genetically transmitted cancers have been identified, and the application of findings from molecular pathology are being evaluated. This article reviews the genetic changes that occur as a result of somatic mutation and inherited or germline mutations.     

Non‐destructive packaging seal strength analysis and leak detection using ultrasonic imaging

This study investigated the effectiveness of ultrasonic imaging for non‐destructive assessment of seal strength in 335 ml polymeric trays. In the first part of this study, the experimental procedures involved filling sample trays with beef enchilada, then sealing at temperatures of 170–260°C for 5 s at 3 bar. Ultrasonic measurements were conducted using an immersion technique in pulse/echo mode. The captured signal amplitudes of the reflections from the samples were digitized and analysed to construct high‐resolution C‐scan ultrasonic images of the seals. The acquired data were statistically analysed for each sample and used as a basis for comparison with the seal (peel) strength, measured as the energy at break. The energy at break was obtained from destructive peel strength analysis, performed using a tensile testing frame. In the second part of this study, ultrasonic imaging was used to predict the performance of the heat sealer used to fabricate the test trays by comparing the seal quality of each of the four quadrants of the samples trays. This study also investigated the minimum channel leak size that could be detected using this ultrasound system. The results of the peel strength analyses showed that a direct correlation exists between seal strength and sealing temperature (170–227°C). Results of the ultrasonic imaging showed that the statistical scatter in the signal amplitude decreased as the sealing temperature increased. This reduction in the scatter of the signal amplitudes indicated a trend of increasing uniformity in the fusion of the two seal faces. Between 170°C and 193°C, sharp changes in the scatter were observed; however, little change was noted for sealing temperatures greater than 193°C, indicating that 204°C could be a minimum recommended sealing temperature. To confirm this result, a drop test analysis was performed on trays filled with beef enchilada and sealed at temperatures of 170–260°C for 5 s at 3 bar. Results of this drop test confirmed that 204°C was the minimum critical sealing temperature. Based on these results, ultrasonic imaging appeared to offer a promising non‐destructive method for the prediction of seal quality in polymeric trays, sealing equipment monitoring and identification of channel leaks ?20 µm in diameter, and is comparable with the more established destructive peel strength analytical method. Copyright © 2003 John Wiley & Sons, Ltd.     

A general procedure for deriving solutions of dual integral equations

Summary In this paper there is developed an operational procedure for deriving solutions of dual integral equations of a general type-equations (1.1) and (1.2) below. The method depends strongly on properties of the Mellin transform. To illustrate the application of the method solutions are derived of the elementary type of dual integral equations occurring in engineering applications. The method is then applied to the solution of dual integral equations of Titchmarsh type and to those involvingY-andK-transforms.Research supported by a National Research Council of Canada grant.