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21.
Algorithm performance evaluation is so entrenched in the machine learning community that one could call it an addiction. Like most addictions, it is harmful and very difficult to give up. It is harmful because it has serious limitations. Yet, we have great faith in practicing it in a ritualistic manner: we follow a fixed set of rules telling us the measure, the data sets and the statistical test to use. When we read a paper, even as reviewers, we are not sufficiently critical of results that follow these rules. Here, we will debate what are the limitations and how to best address them. This article may not cure the addiction but hopefully it will be a good first step along that road. 相似文献
22.
Francillette Yannick Boucher Eric Bier Nathalie Lussier Maxime Bouchard Kévin Belchior Patricia Gaboury Sébastien 《User Modeling and User-Adapted Interaction》2020,30(5):895-947
User Modeling and User-Adapted Interaction - Intelligent environments may improve the independence and quality of life of persons with mild cognitive impairment (MCI) or Alzheimer’s disease... 相似文献
23.
Design challenges of a 65 nm CMOS stacked folded differential PA structure for mobile communications
Yohann Luque Nathalie Deltimple Eric Kerhervé Didier Belot 《Analog Integrated Circuits and Signal Processing》2011,66(2):155-162
In this paper, a novel phase-locked loop (PLL) architecture with multiple charge pumps, which is used to design a fast-locking
PLL and a low-phase-noise PLL, is proposed. The effective capacitance and resistance of the loop filter in terms of voltage
is scaled up/down according to the locking status by controlling the magnitude and direction of the charge pump current. Two
PLLs, one with a fast-locking characteristic and the other with a low-phase-noise characteristic, are designed and fabricated
in a 0.35-μm CMOS process based on the proposed architecture. The fast-locking PLL has a locking time of less than 6 μs and
a phase noise of −90.45 dBc/Hz at 1 MHz offset. The low-phase-noise PLL has a locking time of 25 μs, a phase noise of −105.37 dBc/Hz
at 1 MHz offset, and a reference spur of −50 dBc. Both PLLs have an 851.2 MHz output frequency. 相似文献
24.
Nathalie M. Malewicz Zahra Rattray Sebastian Oeck Sebastian Jung Vicente Escamilla-Rivera Zeming Chen Xiangjun Tang Jiangbing Zhou Robert H. LaMotte 《International journal of molecular sciences》2022,23(9)
Background: Capsaicin, the hot pepper agent, produces burning followed by desensitization. To treat localized itch or pain with minimal burning, low capsaicin concentrations can be repeatedly applied. We hypothesized that alternatively controlled release of capsaicin from poly(lactic-co-glycolic acid) (PLGA) nanoparticles desensitizes superficially terminating nociceptors, reducing burning. Methods: Capsaicin-loaded PLGA nanoparticles were prepared (single-emulsion solvent evaporation) and characterized (size, morphology, capsaicin loading, encapsulation efficiency, in vitro release profile). Capsaicin-PLGA nanoparticles were applied to murine skin and evaluated in healthy human participants (n = 21) for 4 days under blinded conditions, and itch and nociceptive sensations evoked by mechanical, heat stimuli and pruritogens cowhage, β-alanine, BAM8-22 and histamine were evaluated. Results: Nanoparticles (loading: 58 µg capsaicin/mg) released in vitro 23% capsaicin within the first hour and had complete release at 72 h. In mice, 24 h post-application Capsaicin-PLGA nanoparticles penetrated the dermis and led to decreased nociceptive behavioral responses to heat and mechanical stimulation (desensitization). Application in humans produced a weak to moderate burning, dissipating after 3 h. A loss of heat pain up to 2 weeks was observed. After capsaicin nanoparticles, itch and nociceptive sensations were reduced in response to pruritogens cowhage, β-alanine or BAM8-22, but were normal to histamine. Conclusions: Capsaicin nanoparticles could be useful in reducing pain and itch associated with pruritic diseases that are histamine-independent. 相似文献
25.
26.
Stijn Dhondt Cathy Macharis Nathalie Terryn Fredriek Van Malderen Koen Putman 《Accident; analysis and prevention》2013
Statistics on road traffic accidents (RTAs) mainly come from police records. The police reported RTA statistics however are known to have a large degree of under-registration, underestimating the true risk of being injured in traffic accidents. The use of medical based datasets can provide a more accurate estimate of the actual traffic accident health risk. Exposure-based rates of the actual burden from Flanders and Brussels were calculated, comparing differences between road user, age, gender and type of injury sustained. Minimal Clinical Data (MCD) was selected for the years 2003–2007, as well as data from the mortality statistics. Disability Adjusted Life Years (DALY) were calculated and put into perspective with the passenger kilometres travelled. 相似文献
27.
Josée Drillet Nathalie Valle Thierry Iung 《Metallurgical and Materials Transactions A》2012,43(13):4947-4956
The current trend toward producing lighter vehicles in the automotive industry is driven by the need to conform to the new exhaust emission control regulations. This objective presents a challenge to steel manufacturers. The difficulty lies in designing new alloys with an optimum strength/formability/cost balance for the various components. Here, the key to success lies in controlling the steel microstructure and especially the phase transformations at the smallest possible scale. Among the different alloying elements, light elements such as carbon and boron are of prime importance due to their major effects on the kinetics of phase transformations. Characterization tools combining high spatial and analytical resolution such as secondary ion mass spectrometry (SIMS) and field emission gun-transmission electron microscopy (TEM) were used. In this article, the examples presented are as follows. (1) Boron segregation and precipitation effects to control hardenability in martensitic steels. (2) Local carbon distribution in advanced high-strength steels, with a specific emphasis on martensite tempering. Links have been established between the boron and carbon distribution and the formability. 相似文献
28.
Thermal Resonance at the Microscale in AC Scanning Thermal Microscopy with a Thermal-Resistive Probe
Olivier Rapha?l Nathalie Trannoy Philippe Grossel 《International Journal of Thermophysics》2012,33(7):1259-1269
Investigation of the thermal-resistive probe response in an AC scanning thermal microscope (SThM) as a function of the distance probe–material surface under ambient conditions and the current excitation frequency is presented. The analysis of temperature experimental results points out a phenomenon which can be interpreted as a thermal wave resonance. The modeling of the thermal response with the finite element method considering the surrounding medium as a thermally conducting medium tends to confirm this. This phenomenon is independent of the sample nature and is related to the thermal diffusion length of the air medium between the probe and the sample. An equivalent resonance factor is defined: it shows a linear dependence with the characteristic distance for which the thermal resonance phenomenon is an extremum. The system—probe/sample surface—behaves as a resonant cavity at the microscale. This configuration is not specific to a SThM and can occur within electronic devices. 相似文献
29.
30.
Sofiane Aloui Nicolas Delaunay Eric Kerherve Nathalie Deltimple Robert Plana Didier Belot 《Analog Integrated Circuits and Signal Processing》2012,70(2):203-211
A millimeter-wave Power Amplifier (PA) based on a 65nm CMOS technology from STMicroelectronics has been designed. The targeted
feature is the unlicensed band around 60 GHz suitable for wireless personal area network application (WPAN). To optimize the
linearity, the PA is designed under class A biasing to have an output compression point (OCP1) close to its saturated Power (P
sat). S-parameters and large signal measurement results are demonstrated and compared with electromagnetic simulations. The PA
offers a P
sat of 8.3 dBm, an OCP1 of 6 dBm and a gain of 6.7 dB. The die area is 0.29 mm2 with pads. Considering those results, one-tone simulations are not sufficient to characterize the linearity performances
of the PA in its real conditions of use. Consequently, two-tone simulations are firstly performed. After, linearity figures
of merit (FoM) are discussed applying an orthogonal frequency-division multiplexing (OFDM) modulated signal. The PA offers
an adjacent channel power ratio (ACPR) of 15 dB and an error vector magnitude (EVM) of 20% at PA compression operating mode. 相似文献