Gene expression changes in a transgenic mouse model overexpressing human wildtype and mutant torsinA

Primary torsion dystonia is an autosomal-dominantly inherited, neurodevelopmental movement disorder caused by a GAG deletion (ΔGAG) in the DYT1 gene, encoding torsinA. This mutation is responsible for approximately 70% of cases of early-onset primary torsion dystonia. The function of wildtype torsinA is still unknown, and it is unsolved how the deletion in the DYT1 gene contributes to the development of the disease. To better understand the molecular processes involved in torsinA pathology, we used genome-wide oligonucleotide microarrays to characterize gene expression patterns in the striatum of mouse models overexpressing the human wildtype and mutant torsinA. By this approach we were able to detect gene expression changes that seem to be specific for torsinA pathology. We found an impact of torsinA, independent from genotype, on vesicle trafficking, exocytosis, and neurotransmitter release in our mouse model. In addition, we were able to identify several new pathways and processes involved in the development of the nervous system that are affected by wildtype and mutant torsinA. Furthermore, we have striking evidence from our gene expression data that glutamate receptor mediated synaptic plasticity in the striatum is the affected underlying cellular process for impaired motor learning in human ΔGAG torsinA transgenic mice.     

Performance evaluation of priority CSMA-CA mechanism on ISA100.11a wireless network

The International Society of Automation recently released ISA100.11a as an open standard for reliable wireless networks for industrial automation. ISA100.11a uses the TDMA scheme in the medium access layer to provide deterministic services. However, ISA100.11a adopts the CSMA-CA mechanism with priorities for retransmission from failure on dedicated links, sporadic data, and network configuration.This paper evaluates ISA100.11a CSMA-CA by simulation, considering the effects of backoff procedures and priority settings to probability of collision and successful use of slots. It's demonstrated that a high number of priority classes enable better network utilization resulting in less number of packets exceeding their lifetime.     

Pre‐convolved Radiance Caching

The incident indirect light over a range of image pixels is often coherent. Two common approaches to exploit this inter‐pixel coherence to improve rendering performance are Irradiance Caching and Radiance Caching. Both compute incident indirect light only for a small subset of pixels (the cache), and later interpolate between pixels. Irradiance Caching uses scalar values that can be interpolated efficiently, but cannot account for shading variations caused by normal and reflectance variation between cache items. Radiance Caching maintains directional information, e.g., to allow highlights between cache items, but at the cost of storing and evaluating a Spherical Harmonics (SH) function per pixel. The arithmetic and bandwidth cost for this evaluation is linear in the number of coefficients and can be substantial. In this paper, we propose a method to replace it by an efficient per‐cache item pre‐filtering based on MIP maps — such as previously done for environment maps — leading to a single constant‐time lookup per pixel. Additionally, per‐cache item geometry statistics stored in distance‐MIP maps are used to improve the quality of each pixel's lookup. Our approximate interactive global illumination approach is an order of magnitude faster than Radiance Caching with Phong BRDFs and can be combined with Monte Carlo‐raytracing, Point‐based Global Illumination or Instant Radiosity.     

A multi-start iterated local search with tabu list and path relinking for the two-echelon location-routing problem

The two-echelon location-routing problem (LRP-2E) is raised by the design of transportation networks with two types of trips: first-level trips serving from one main depot a set of satellite depots, to be located, and second-level trips supplying customers from these satellites. In the proposed multi-start iterated local search (MS-ILS), three greedy randomized heuristics are used cyclically to get initial solutions. Each ILS run alternates between two search spaces: LRP-2E solutions, and travelling salesman (TSP) tours covering the main depot and the customers. The number of iterations allotted to a run is reduced whenever a known solution (stored in a tabu list) is revisited. MS-ILS can be reinforced by a path-relinking procedure (PR), used internally for intensification, as post-optimization, or both. On two sets with 24 and 30 LRP-2E instances, MS-ILS outperforms on average two GRASP algorithms and adding PR brings a further improvement. Our metaheuristic also surpasses a tabu search on 30 instances for a more general problem with several main depots. It is still effective on a particular case, the capacitated location-routing problem (CLRP): In a comparison with four published metaheuristics, only one (LRGTS, Prins et al., 2007) does better.     

Comportement électrocatalytique vis à vis de la réduction d'oxygène des oxydes mixtes AxByMn3−(x+y)O4

Résumé Les résultats expérimentaux présentés dans cette étude et ceux publiés précédemment montrent que l'électroréduction de l'oxygène se fait dans les sites actifs formés par des ions Mn⁴⁺, et que ceux de Mn³⁺ assurent le transport des électrons au sein du solide.

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From the results obtained in this study and those presented in previous publications, it can be deduced that the electroreduction of oxygen occurs via electron transfers at active sites created by Mn⁴⁺ ions and that Mn³⁺ ions contribute to the transport of the electrons through the bulk of the electrocatalysts.

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Certains de ces résultats ont fait l'object d'une communication enPoster à la réunion I.S.E. à Varna, Septembre 1977.

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A=Zn, Cr, Al;B = Ni, Cu; et 0 x,y 1.     

A photonic technique for microwave frequency measurement

A novel photonic technique for microwave frequency measurement utilizing dispersion in a multichannel chirped fiber Bragg grating is presented. The technique is based on the amplitude comparison of power fading functions generated by double sideband modulated optical carriers propagating through a dispersive medium.     

Low-power-consumption and high-gain CMOS distributed amplifiers using cascade of inductively coupled common-source gain cells for UWB systems

A distributed amplifier with new cascade inductively coupled common-source gain-cell configuration is presented. Compared with other existing gain-cell configurations, the proposed cascade common-source gain cell can provide much higher transconductance and, hence, gain. The new distributed amplifier using the proposed gain-cell configuration, fabricated via a TSMC 0.18-/spl mu/m CMOS process, achieves an average power gain of around 10 dB, input match of less than -20 dB, and noise figure of 3.3-6.1 dB with a power consumption of only 19.6 mW over the entire ultra-wideband (UWB) band of 3.1-10.6 GHz. This is the lowest power consumption ever reported for fabricated CMOS distributed amplifiers operating over the whole UWB band. In the high-gain operating mode that consumes 100 mW, the new CMOS distributed amplifier provides an unprecedented power gain of 16 dB with 3.2-6-dB noise figure over the UWB range.     

Comments on “Capture and Retransmission Control in Mobile Radio”

For original paper by Zorzi and Rao, see IEEE J. Sel. Areas Commun., vol.12, no.8, p.1289-98 (1994 October)     

High-power high-Modulation-speed 1060-nm DBR lasers for Green-light emission

We report on the static and dynamic performance of high-power and high-modulation-speed 1060-nm distributed Bragg reflector (DBR) lasers for green-light emission by second-harmonic generation. Single-wavelength power of 387 mW at 1060-nm wavelength and green power as high as 99.5 mW were achieved. A thermally induced wavelength tuning of 2.4 nm and a carrier-induced wavelength tuning of -0.85 nm were obtained by injecting current into the DBR section. Measured rise-fall times of 0.2 ns for direct intensity modulation and 0.6 ns for wavelength modulation make the lasers suitable for >50-MHz green-light modulation applications.     

Poromechanics Response of Inclined Wellbore Geometry in Fractured Porous Media

This paper presents the poromechanics/poroelastic analytical solution for stress and pore pressure fields induced by the action of drilling and/or the pressurization of an inclined/horizontal wellbore in fractured fluid-saturated porous media, or naturally fractured fluid-saturated rock formations. The model which is developed within the framework of the coupled processes in the dual-porosity/dual-permeability approach accounts for coupled isothermal fluid flow and rock/fractures deformation. The solution to the inclined/horizontal wellbore problem is derived for a wellbore drilled in an infinite naturally fractured poroelastic medium, subjected to three-dimensional in situ state of stress and pore pressure. The dual-porosity analytical solution is first reduced to the limiting single-porosity case and verified against an existing single-porosity solution. A comparison between single-porosity and dual-porosity poroelastic results is conducted and displayed in this work. Finally, wellbore stability analyses have been carried out to demonstrate possible applications of the solution.