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21.
This article is based on experiences with data and text mining to gain information for strategic business decisions, using host-based analysis and visualisation (A/V), primarily in the field of patents. The potential advantages of host-based A/V are pointed out and the features of the first such A/V software, STN®AnaVist™, are described in detail. Areas covered include the user interfaces, initial set of documents for A/V, data mining, text mining, reporting, and suggestions for further development. 相似文献
22.
23.
Peridynamic modeling of concrete structures 总被引:3,自引:0,他引:3
Walter Gerstle Nicolas Sau Stewart Silling 《Nuclear Engineering and Design》2007,237(12-13):1250-1258
The peridynamic model described in Silling (Silling, S.A., 1998. Reformation of Elasticity Theory for Discontinuous and Long-Range Forces, SAND98-2176. Sandia National Laboratories, Albuquerque, NM), being a central-force model, is limited to modeling materials with a Poisson's ratio of 1/4. In this paper, the peridynamic model is generalized by adding pairwise peridynamic moments to simulate linear elastic materials with varying Poisson's ratios. The new model is called the “micropolar peridynamic model”. The micropolar peridynamic model is placed within a finite element context to enable efficacious application of boundary conditions and efficient computational solutions using an implicit, rather than an explicit solution algorithm. The implicit solution algorithm is suitable for quasistatic simulation of damage and cracking in concrete structures. With this new model, very simple tensile damage mechanisms at the micro structural (peridynamic) level are sufficient to explain a great deal of the microcracking (damage) and fracture mechanics observed in concrete structures. The new implementation appears to be computationally efficient. 相似文献
24.
Guimond Serge; Dambrun Micha?l; Michinov Nicolas; Duarte Sandra 《Canadian Metallurgical Quarterly》2003,84(4):697
Social dominance orientation (SDO) has been proposed as an important variable in the explanation of prejudice. We distinguish between three conceptualizations of SDO: SDO as a personality trait (personality model), SDO as a moderator of the effects of situational variables (Person X Situation model), and SDO as a mediator of the effect of social position on prejudice (group socialization model [GSM]). Four studies (N = 1,657) looking at the relations between social positions, SDO, and prejudice in a natural setting and in a laboratory setting provide strong support for the GSM. In contrast to previous correlational findings, there is evidence of a cause (dominant social position), an effect (prejudice increases), and a mediator (SDO). These results suggest new perspectives on the integration of individual and contextual determinants of prejudice. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
25.
This paper analyses the technical efficiency in the hydroelectric generating plants of a main Portuguese electricity enterprise EDP (Electricity of Portugal) between 1994 and 2004, investigating the role played by increase in competition and regulation. A random cost frontier method is adopted. A translog frontier model is used and the maximum likelihood estimation technique is employed to estimate the empirical model. We estimate the efficiency scores and decompose the exogenous variables into homogeneous and heterogeneous. It is concluded that production and capacity are heterogeneous, signifying that the hydroelectric generating plants are very distinct and therefore any energy policy should take into account this heterogeneity. It is also concluded that competition, rather than regulation, plays the key role in increasing hydroelectric plant efficiency. 相似文献
26.
Ethidium was found to be efficiently cross-linked to DNA by glyoxal. Kinetic studies showed that the rate of the cross-linking reaction is strongly dependent on the glyoxal concentration. Comparative studies using a series of phenanthridines and acridines showed that NH2 groups at both the 2 and 7 positions on the phenanthridine ring are necessary for efficient cross-linking. Studies using synthetic polydeoxynucleotides showed that the 2-amino group of guanine is absolutely required for cross-linking. Fluorescence contact energy transfer and relative viscosity experiments showed that the cross-linked drug remains intercalated into DNA. DNA gel electrophoresis and melting studies demonstrated that cross-linked ethidium does not dissociate the DNA double helix to single strands. 相似文献
27.
M Krasteva J Kehren F Horand H Akiba G Choquet MT Ducluzeau R Tédone JL Garrigue D Kaiserlian JF Nicolas 《Canadian Metallurgical Quarterly》1998,160(3):1181-1190
We have previously reported that contact sensitivity (CS) to dinitrofluorobenzene (DNFB) in C57BL/6 mice was mediated by MHC class I-restricted CD8+ T cells and down-regulated by MHC class II-restricted CD4+ T cells. In this study, we analyzed the contribution of dendritic cells (DC) in the induction of these two T cell subsets endowed with opposite functions. Hapten-pulsed skin- and bone marrow-derived DC, obtained from either normal C57BL/6 mice or from MHC class II (I+ II-) and MHC class I (I- II+)-deficient mice, were tested for their ability to prime normal mice for CS to dinitrofluorobenzene. Expression of MHC class I molecules by transferred DC was mandatory both for the induction of CS and for the generation of hapten-specific CD8+ T cells in lymphoid organs. I+ II- DC were as potent as I+ II+ DC in priming for CS, demonstrating that activation of effector CD8+ T cells can occur independently of CD4+ T cell help. I- II+ DC could not immunize for CS, although they could sensitize for a delayed-type hypersensitivity reaction to protein Ags. Moreover, I- II+ DC injected simultaneously with cutaneous sensitization down-regulated the inflammatory response, suggesting that hapten presentation by MHC class II molecules could prime regulatory CD4+ T cells. These results indicate that DC can present haptenated peptides by both MHC class I and class II molecules and activate Ag-specific CD8+ effector and CD4+ regulatory T cell subsets, concurrently and independently. 相似文献
28.
Farouk Belkadi Nicolas Dremont Alban Notin Nadege Troussier Mourad Messadia 《Annual Reviews in Control》2012,36(2):346-358
The design of complex system requires a lot of interactions between experts and then between numerous Computer Aided X software (CAX) (where X can be Design (CAD), Engineering (CAE), Manufacturing (CAM), etc.). In order to improve the consistency of the whole system design and the related data and information, knowledge crossing the expertises must be tracked and formalized regarding a shared reference. That means that instead of defining a large reference models to which each expert refers to, a light collaborative model is defined enabling to connect data from each expert model to adhoc data from other expert models, following the least commitment principle. In this topic, a new meta-model is proposed in a Model-Driven Engineering approach to manage the integration of heterogeneous experts’ knowledge models in a collaborative process. The structure of the proposed knowledge meta-model is defined taking into account the complexity of knowledge definition and the properties of its components. This meta-model is split in a meta-model of data on one hand and a Collaboration Meta-Model in the other hand, to represent the distinction between the core concepts of knowledge and additional elements serving to represent the relation between these concepts, and between concepts of heterogeneous experts’ models. The proposed meta-model is illustrated on an industrial case study to highlight the way to put it in use, and its interests to enable collaboration between experts throughout the design process. 相似文献
29.
Ogier Maitre Frédéric Krüger Stéphane Querry Nicolas Lachiche Pierre Collet 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2012,16(2):261-279
EASEA is a framework designed to help non-expert programmers to optimize their problems by evolutionary computation. It allows
to generate code targeted for standard CPU architectures, GPGPU-equipped machines as well as distributed memory clusters.
In this paper, EASEA is presented by its underlying algorithms and by some example problems. Achievable speedups are also
shown onto different NVIDIA GPGPUs cards for different optimization algorithm families. 相似文献
30.
Alexander Kutschera Ursula Schombel Dominik Schwudke Stefanie Ranf Nicolas Gisch 《International journal of molecular sciences》2021,22(6)
Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host–pathogen interactions in particular. Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations. The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen Pseudomonas aeruginosa. A few core-OS structures of plant-associated Pseudomonas strains have been solved to date, but the genetic components of the underlying biosynthesis remained unclear. We conducted a comparative genome analysis of the core-OS gene cluster in Pseudomonas syringae pv. tomato (Pst) DC3000, a widely used model pathogen in plant–microbe interactions, within the P. syringae species complex and to other plant-associated Pseudomonas strains. Our results suggest a genetic and structural conservation of the inner core-OS but variation in outer core-OS composition within the P. syringae species complex. Structural analysis of the core-OS of Pst DC3000 shows an uncommonly high phosphorylation and presence of an O-acetylated sugar. Finally, we combined the results of our genomic survey with available structure information to estimate the core-OS composition of other Pseudomonas species. 相似文献