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61.
Applied Intelligence - Recent success in scaling deep reinforcement algorithms (DRL) to complex problems has been driven by well-designed extrinsic rewards, which limits their applicability to many... 相似文献
62.
Ester Sporleder Yasmin Assan Shasha Rao David Warther Clive A. Prestidge Jean‐Olivier Durand Nicolas H. Voelcker 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(29)
There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody‐functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug. This approach represents a targeted two‐stage delivery nanocarrier that benefits from a dual therapeutic action that results in enhanced cytotoxicity. 相似文献
63.
Writing with Fluid: Structuring Hydrogels with Micrometer Precision by AFM in Combination with Nanofluidics
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Nicolas Helfricht Andreas Mark Marina Behr Andreas Bernet Hans‐Werner Schmidt Georg Papastavrou 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(31)
Hydrogels have many applications in biomedical surface modification and tissue engineering. However, the structuring of hydrogels after their formation represents still a major challenge, in particular due to their softness. Here, a novel approach is presented that is based on the combination of atomic force microscopy (AFM) and nanofluidics, also referred to as FluidFM technology. Its applicability is demonstrated for supramolecular hydrogel films that are prepared from low‐molecular weight hydrogelators, such as derivates of 1,3,5‐benzene tricarboxamides (BTAs). BTA films can be dissolved selectively by ejecting alkaline solution through the aperture of a hollow AFM‐cantilever connected to a nanofluidic controller. The AFM‐based force control is essential in preventing mechanical destruction of the hydrogels. The resulting “chemical writing” process is studied in detail and the influence of various parameters, such as applied pressure and time, is validated. It is demonstrated that the achievable structuring precision is primarily limited by diffusion and the aperture dimensions. Recently, various additive techniques have been presented to pattern hydrogels. The here‐presented subtractive approach can not only be applied to structure hydrogels from the large class of reversibly formed gels with superior resolution but would also allow for the selective loading of the hydrogels with active substances or nanoparticles. 相似文献
64.
Anticipating Cutoff Diameters in Deterministic Lateral Displacement (DLD) Microfluidic Devices for an Optimized Particle Separation
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Eloise Pariset Catherine Pudda François Boizot Nicolas Verplanck Jean Berthier Aurélie Thuaire Vincent Agache 《Small (Weinheim an der Bergstrasse, Germany)》2017,13(37)
Deterministic lateral displacement (DLD) devices enable to separate nanometer to micrometer‐sized particles around a cutoff diameter, during their transport through a microfluidic channel with slanted rows of pillars. In order to design appropriate DLD geometries for specific separation sizes, robust models are required to anticipate the value of the cutoff diameter. So far, the proposed models result in a single cutoff diameter for a given DLD geometry. This paper shows that the cutoff diameter actually varies along the DLD channel, especially in narrow pillar arrays. Experimental and numerical results reveal that the variation of the cutoff diameter is induced by boundary effects at the channel side walls, called the wall effect. The wall effect generates unexpected particle trajectories that may compromise the separation efficiency. In order to anticipate the wall effect when designing DLD devices, a predictive model is proposed in this work and has been validated experimentally. In addition to the usual geometrical parameters, a new parameter, the number of pillars in the channel cross dimension, is considered in this model to investigate its influence on the particle trajectories. 相似文献
65.
66.
Nathan?SellesEmail author Andrew?King Henry?Proudhon Nicolas?Saintier Lucien?Laiarinandrasana 《Mechanics of Time-Dependent Materials》2018,22(3):351-371
Double notched round bars made of semi-crystalline polymer polyamide 6 (PA6) were submitted to monotonic tensile and creep tests. The two notches had a root radius of 0.45 mm, which imposes a multiaxial stress state and a state of high triaxiality in the net (minimal) section of the specimens. Tests were carried out until the failure occurred from one of the notches. The other one, unbroken but deformed under steady strain rate or steady load, was inspected using the Synchrotron Radiation Computed Tomography (SRCT) technique. These 3D through thickness inspections allowed the study of microstructural evolution at the peak stress for the monotonic tensile test and at the beginning of the tertiary creep for the creep tests. Cavitation features were assessed with a micrometre resolution within the notched region. Spatial distributions of void volume fraction (\(\mathit{Vf}\)) and void morphology were studied. Voiding mechanisms were similar under steady strain rates and steady loads. The maximum values of \(\mathit{Vf}\) were located between the axis of revolution of the specimens and the notch surface and voids were considered as flat cylinders with a circular basis perpendicular to the loading direction. A model, based on porous plasticity, was used to simulate the mechanical response of this PA6 material under high stress triaxiality. Both macroscopic behaviour (loading curves) and voiding micro-mechanisms (radial distributions of void volume fraction) were accurately predicted using finite element simulations. 相似文献
67.
Novel GaInSbAs/GaSb multiple-quantum-well lasers operating near room temperature have been successfully used for tunable diode laser absorption spectroscopy in the vicinity of 2.35 mum. Continuous current tuning over a more than 150-GHz frequency range has been realized. Direct absorption measurements have been carried out on the R, R, R, and R lines of carbon monoxide. Traces of carbon monoxide at the level of 0.3 part in 10(6) in volume at 100 Torr could be detected by the low-frequency wavelength-modulation technique and an astigmatic multipass cell. These results show a potential use of these diode lasers in portable low-cost trace-pollutant sensors. 相似文献
68.
Emmanuel Bruno Nicolas Faessel Herv�� Glotin Jacques Le Maitre Michel Scholl 《World Wide Web》2011,14(5-6):623-649
We present in this paper a model for indexing and querying web pages, based on the hierarchical decomposition of pages into blocks. Splitting up a page into blocks has several advantages in terms of page design, indexing and querying such as (i) blocks of a page most similar to a query may be returned instead of the page as a whole (ii) the importance of a block can be taken into account, as well as (iii) the permeability of the blocks to neighbor blocks: a block b is said to be permeable to a block b?? in the same page if b?? content (text, image, etc.) can be (partially) inherited by b upon indexing. An engine implementing this model is described including: the transformation of web pages into blocks hierarchies, the definition of a dedicated language to express indexing rules and the storage of indexed blocks into an XML repository. The model is assessed on a dataset of electronic news, and a dataset drawn from web pages of the ImagEval campaign where it improves by 16% the mean average precision of the baseline. 相似文献
69.
Aerodynamic instabilities that naturally occur in compression systems, such as surge and rotating stall, largely reduce the life duration and performance of system components. The prediction of the compressor operating range is thus a key parameter for the design of gas turbines. This paper investigates the ability of an unsteady flow solver to simulate the rotating stall phenomenon in the full annulus of an axial compressor stage. A comparison with experimental data indicates that the simulation correctly estimates the stability limit. However the rotating stall flow patterns are different. While measurements show only one full span rotating stall cell (40 Hz), the simulation shows first a part span stall with 10 cells (790 Hz) that evolves then towards a full span stall with three cells (170 Hz). A spectral analysis based on numerical results underlines the role of rotor-stator interactions in the development of rotating stall. The effects of downstream volumes and inlet distortions are also discussed, showing the necessity to consider the whole geometry to correctly predict the rotating stall frequency. 相似文献
70.
Jose Gonzalez-Mora Fernando De la Torre Nicolas Guil Emilio L. Zapata 《Image and vision computing》2010
Over the last decade 3D face models have been extensively used in many applications such as face recognition, facial animation and facial expression analysis. 3D Morphable Models (MMs) have become a popular tool to build and fit 3D face models to images. Critical to the success of MMs is the ability to build a generic 3D face model. Major limitations in the MMs building process are: (1) collecting 3D data usually involves the use of expensive laser scans and complex capture setups, (2) the number of available 3D databases is limited, and typically there is a lack of expression variability and (3) finding correspondences and registering the 3D model is a labor intensive and error prone process. 相似文献