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排序方式: 共有1364条查询结果,搜索用时 15 毫秒
31.
Julie M. Vandenbossche Nicole Dufalla Zichang Li 《International Journal of Pavement Engineering》2017,18(11):1004-1015
Bonded concrete overlays of asphalt pavements (BCOAs) are becoming a common rehabilitation technique used for distressed hot mix asphalt (HMA) roadways. The original design procedures were based primarily on data from instrumented pavements and finite element modelling. They were governed by the assumption that the failure mechanism was a function of the overlay thickness. However, field observations have indicated that the actual failure modes are dictated by slab size. The newly developed Bonded Concrete Overlay of Asphalt Mechanistic-Empirical design procedure (BCOA-ME) presented here is valid for overlays that are between 2.5 and 6.5 in (64–154 mm), and includes five primary enhancements to the Portland Cement Association and Colorado Department of Transportation procedures that have been traditionally used: 1.) the failure mode is dictated by the joint spacing; 2.) a new structural model for longitudinal cracking for 6-ft × 6-ft (1.8 m × 1.8 m) concrete overlays has been developed to better predict the critical stresses; 3.) the stress adjustment factors have been calibrated with performance data; 4.) the equivalent temperature gradients used as design input are defined based on the pavement structure and geographical location of the project; and 5.) the effect of temperature change on underlying HMA stiffness is considered. Finally, validation studies were completed on the new procedure and comparisons made between the revised procedure and actual performance data for five separate projects showed reasonable results. A sensitivity analysis also revealed that the predicted thickness obtained using the revised procedure was sensitive to HMA thickness, the modulus of rupture of the Portland cement concrete, and the level of traffic, as would be expected. 相似文献
32.
Identifying and integrating patient and caregiver perspectives for clinical practice guidelines on the screening and management of infectious microorganisms in hemodialysis units
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Hilary M. Miller Allison Tong David J. Tunnicliffe Denise Campbell Jule Pinter Robert J. Commons Eugene Athan Jonathan C. Craig Nicole Gilroy Julianne Green Belinda Henderson Martin Howell Rhonda L. Stuart Carolyn van Eps Muh Geot Wong Janak de Zoysa Meg J. Jardine 《Hemodialysis international. International Symposium on Home Hemodialysis》2017,21(2):213-223
33.
Optimized Photoinitiator for Fast Two‐Photon Absorption Polymerization of Polyester‐Macromers for Tissue Engineering
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34.
35.
Gemma M. Paech Sarah M. Jay Nicole Lamond Gregory D. Roach Sally A. Ferguson 《Applied ergonomics》2010,41(4):600-606
Shiftwork involving early morning starts and night work can affect both sleep and fatigue. This study aimed to assess the impact of different rostering schedules at an Australian mine site on sleep and subjective sleep quality. Participants worked one of four rosters;
- 4 × 4 (n = 14) 4D4O4N4O
- 7 × 4 (n = 10) 7D4O7N40
- 10 × 5 (n = 17) 5D5N50
- 14 × 7 (n = 12) 7D7N70
36.
Rosanna E. Guadagno Nicole L. MuscanellBradley M. Okdie Nanci M. BurkThomas B. Ward 《Computers in human behavior》2011,27(1):304-308
The present study examined whether traditional gender role expectations (Eagly, 1987) influence behaviors in non-traditional contexts such as online virtual environments. Participants were 352 Second Life users who reported their activities and experiences in Second Life. Results indicated that men and women differed in the types of activities they engaged in a manner predicted by social role theory. Specifically, as compared to women, men were more likely to report building things (e.g. objects), to own and work on their own virtual property, and were less likely to change their avatar’s appearance. Women, as compared to men, were more likely to meet people, shop, regularly change their avatar’s appearance, and buy clothes/objects for their avatar. The present study adds to our understanding of how traditional gender role expectations may carry over to online virtual worlds and influence online behavior. 相似文献
37.
Efficient and robust shot change detection 总被引:6,自引:0,他引:6
In this article, we deal with the problem of shot change detection which is of primary importance when trying to segment and
abstract video sequences. Contrary to recent experiments, our aim is to elaborate a robust but very efficient (real-time even
with uncompressed data) method to deal with the remaining problems related to shot change detection: illumination changes,
context and data independency, and parameter settings. To do so, we have considered some adaptive threshold and derivative
measures in a hue-saturation colour space. We illustrate our robust and efficient method by some experiments on news and football
broadcast video sequences.
相似文献
Nicole VincentEmail: |
38.
This study examined the use of deliberately anthropomorphic automation on younger and older adults' trust, dependence and performance on a diabetes decision-making task. Research with anthropomorphic interface agents has shown mixed effects in judgments of preferences but has rarely examined effects on performance. Meanwhile, research in automation has shown some forms of anthropomorphism (e.g. etiquette) have effects on trust and dependence on automation. Participants answered diabetes questions with no-aid, a non-anthropomorphic aid or an anthropomorphised aid. Trust and dependence in the aid was measured. A minimally anthropomorphic aide primarily affected younger adults' trust in the aid. Dependence, however, for both age groups was influenced by the anthropomorphic aid. Automation that deliberately embodies person-like characteristics can influence trust and dependence on reasonably reliable automation. However, further research is necessary to better understand the specific aspects of the aid that affect different age groups. Automation that embodies human-like characteristics may be useful in situations where there is under-utilisation of reasonably reliable aids by enhancing trust and dependence in that aid. Practitioner Summary: The design of decision-support aids on consumer devices (e.g. smartphones) may influence the level of trust that users place in that system and their amount of use. This study is the first step in articulating how the design of aids may influence user's trust and use of such systems. 相似文献
39.
Nicole Altvater-Mackensen Gregor Balicki Lucie Bestakowa Bianca Bocatius Johannes Braun Lars Brehmer Verena Brune Kirstina Eigemeier F&#;sun Erdem Ralf Fritscher Anne Jacobs Bernd Klingsporn Marcin Kosinski Julia Kuntze Ju-Ra Lee Anna Osterhage Martin Probost Thorsten Risch Tobias Schmitt Wolfgang G. Stock Anja Sturm Katrin Weller Kerstin Werner 《Scientometrics》2005,63(3):463-529
Summary We operationalize scientific output in a region by means of the number of articles (as in the SciSearch database) per year and technology output by means of the number of patent applications (as in the database of the European Patent Office) per priority year. All informetric analyses were done using the DIALOG online-system. The main research questions are the following: Which scientific and technological fields or topics are most influent within a region and which institutions or companies are mainly publishing articles or holding patents? Do the distributions of regional science and technology fields and of publishing institutions follow the well-known informetric function? Are there - as it is expected - only few fields and few institutions which dominate the region? Is there a connection between the economic power of a region and the regional publication and patent output? Examples studied in detail are seven German regions: Aachen, Düsseldorf, Hamburg, Köln (Cologne), Leipzig - Halle - Dessau, München (Munich), and Stuttgart. Three different indicators were used, science and technology attraction of a region (number of scientific articles and patents), science and technology intensity (articles and patents per 1,000 inhabitants), and science and technology density (articles and patents per 1 billion EURO gross value added). Top region concerning both attraction and intensity is Munich, concerning density it is Aachen. 相似文献
40.
Eline A. M. Ruigrok Nicole S. Verkaik Erik de Blois Corrina de Ridder Debra Stuurman Stefan J. Roobol Dik C. Van Gent Marion de Jong Wytske M. Van Weerden Julie Nonnekens 《International journal of molecular sciences》2022,23(14)
Prostate specific membrane antigen targeted radionuclide therapy (PSMA-TRT) is a promising novel treatment for prostate cancer (PCa) patients. However, PSMA-TRT cannot be used for curative intent yet, thus additional research on how to improve the therapeutic efficacy is warranted. A potential way of achieving this, is combining TRT with poly ADP-ribosylation inhibitors (PARPi), which has shown promising results for TRT of neuroendocrine tumor cells. Currently, several clinical trials have been initiated for this combination for PCa, however so far, no evidence of synergism is available for PCa. Therefore, we evaluated the combination of PSMA-TRT with three classes of PARPi in preclinical PCa models. In vitro viability and survival assays were performed using PSMA-expressing PCa cell lines PC3-PIP and LNCaP to assess the effect of increasing concentrations of PARPi veliparib, olaparib or talazoparib in combination with PSMA-TRT compared to single PARPi treatment. Next, DNA damage analyses were performed by quantifying the number of DNA breaks by immunofluorescent stainings. Lastly, the potential of the combination treatments was studied in vivo in mice bearing PC3-PIP xenografts. Our results show that combining PSMA-TRT with PARPi did not synergistically affect the in vitro clonogenic survival or cell viability. DNA-damage analysis revealed only a significant increase in DNA breaks when combining PSMA-TRT with veliparib and not in the other combination treatments. Moreover, PSMA-TRT with PARPi treatment did not improve tumor control compared to PSMA-TRT monotherapy. Overall, the data presented do not support the assumption that combining PSMA-TRT with PARPi leads to a synergistic antitumor effect in PCa. These results underline that extensive preclinical research using various PCa models is imperative to validate the applicability of the combination strategy for PCa, as it is for other cancer types. 相似文献