Using PIV to measure granular temperature in saturated unsteady polydisperse granular flows

The motion of debris flows, gravity-driven fast moving mixtures of rock, soil and water can be interpreted using the theories developed to describe the shearing motion of highly concentrated granular fluid flows. Frictional, collisional and viscous stress transfer between particles and fluid characterizes the mechanics of debris flows. To quantify the influence of collisional stress transfer, kinetic models have been proposed. Collisions among particles result in random fluctuations in their velocity that can be represented by their granular temperature, T. In this paper particle image velocimetry, PIV, is used to measure the instantaneous velocity field found internally to a physical model of an unsteady debris flow created by using “transparent soil”—i.e. a mixture of graded glass particles and a refractively matched fluid. The ensemble possesses bulk properties similar to that of real soil-pore fluid mixtures, but has the advantage of giving optical access to the interior of the flow by use of plane laser induced fluorescence, PLIF. The relationship between PIV patch size and particle size distribution for the front and tail of the flows is examined in order to assess their influences on the measured granular temperature of the system. We find that while PIV can be used to ascertain values of granular temperature in dense granular flows, due to increasing spatial correlation with widening gradation, a technique proposed to infer the true granular temperature may be limited to flows of relatively uniform particle size or large bulk.     

Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures

Binary asymmetric nanocrystals (BNCs), composed of a photoactive TiO₂ nanorod joined with a superparamagnetic γ-Fe₂O₃ spherical domain, were embedded in polyethylene glycol modified phospholipid micelle and successfully bioconjugated to a suitably designed peptide containing an RGD motif. BNCs represent a relevant multifunctional nanomaterial, owing to the coexistence of two distinct domains in one particle, characterized by high photoactivity and magnetic properties, that is particularly suited for use as a phototherapy and hyperthermia agent as well as a magnetic probe in biological imaging. We selected the RGD motif in order to target integrin expressed on activated endothelial cells and several types of cancer cells. The prepared RGD-peptide/BNC conjugates, comprehensively monitored by using complementary optical and structural techniques, demonstrated a high stability and uniform dispersibility in biological media. The cytotoxicity of the RGD-peptide/BNC conjugates was studied in vitro. The cellular uptake of RGD-peptide conjugates in the cells, assessed by means of two distinct approaches, namely confocal microscopy analysis and emission spectroscopy determination in cell lysates, displayed selectivity of the RGD-peptide-BNC conjugate for the αvβ3 integrin. These RGD-peptide-BNC conjugates have a high potential for theranostic treatment of cancer.

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Unilateral spatial neglect in degenerative brain pathology.

Objective: In an attempt to interpret neglect as a disconnection syndrome, it is currently proposed that the disorder results from disorganization of large-scale networks involved in attentional spatial processes rather than of individual brain areas. We hypothesize that as degenerative brain diseases are “system pathologies,” degeneration could be restricted to some of the neural subsystems implicated in the functional organization of spatial attention and different neglect syndromes could emerge depending on the patterns of the subsystems involved. Method: We studied five neglect patients: one with corticobasal degeneration (CBD), three with Posterior Cortical Atrophy (PCA) and one with frontotemporal dementia (FTD). Results: The patient with CBD and left parietoccipital atrophy showed right allocentric neglect; the three patients with PCA mostly distributed in the right posterior regions showed left egocentric extrapersonal neglect; the patient with FTD, who displayed more severe frontotemporal atrophy on the right, had left motor-executive neglect for both personal and extrapersonal space. All patients also presented a deep breakdown of spatial working memory. Conclusion: Our data would confirm that left neglect is more frequent than right neglect also in degenerative pathology and that damage to different neural substrates can produce different types of neglect. Our findings are also consistent with the hypothesis that both lateralized and nonlateralized attention disorders contribute to generate the syndrome. We suggest that evidence from degenerative diseases may contribute to construction of models of spatial attention. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Influence of aggregate mineralogy on alkali–silica reaction studied by X-ray powder diffraction and imaging techniques

Reliable assessment of the potential alkali reactivity of aggregate to develop deleterious alkali–silica reaction is essential for construction of durable concrete structures. The potential alkali reactivity of silicified limestone and two limestones has been investigated. Preliminary characterisation of aggregate was performed by optical and environmental scanning electron microscopy. X-ray powder diffraction peak profile analysis was used to predict the aggregates’ potential alkali reactivity. Samples were aged in accordance to the RILEM AAR-2 procedure and further characterised by means of optical and environmental scanning electron microscopy as well as by synchrotron X-ray microtomography, where quantitative analysis relative to damage due to the alkali–silica reaction (ASR) was performed by morphometric analysis of volume data. Results highlight that (1) the microstructural domain size and microstrain values extracted form XRPD line profile analysis seem to be good parameters for predicting the potential alkali reactivity of quartz in aggregate, and (2) the mineralogy of the aggregate influences the weathering products (i.e. aggregate dissolution, ASR gel growth and microcracking) due to ASR in cement-based materials.     

LMF-aware Web services for accessing semantic lexicons

This paper demonstrates that Wordnet-LMF, a version of ISO LMF, allows us to effectively design and implement Web services for accessing WordNet-type semantic lexicons that conform to the REST Web service architecture. The implemented prototype service currently provides access to native wordnets as well as to a bilingual concept dictionary. This paper thus describes slight revisions that were made to the Wordnet-LMF specifications to model and accommodate a non-wordnet-native bilingual concept dictionary.     

Methylaluminoxane: only a cocatalyst or something more?

Summary Methylaluminoxane (MAO) was used as a catalyst for the polymerization of several vinyl monomers. Polymer yields were found to decrease in the order styrene > isobutyl vinyl ether > methyl methacrylate ≈ acrylonitrile > α-methylstyrene > vinyl acetate = 0. The polymers exhibit low to moderate molar mass with broad distributions. NMR analysis were used to determine the polymers steric microstructure and the end groups. MAO was also able to produce styrene-methyl methacrylate, styrene-isobutyl vinyl ether and methyl methacrylate-isobutyl vinyl ether copolymers. Experimental evidences are against ionic polymerization mechanisms, whereas proofs for a radical mechanism are more controversial, but altogether against of it.     

Chemical structure of long-chain esters from “sansa” olive oil

The major objective of this study was to determine the chemical structure of long-chain esters present in lower-grade olive oil. The classes of esters composing the hexanediethyl ether (99∶1) extract of the wax fraction from a pomace olive oil were: (i) esters of oleic acid with C₁−C₆ alcohols, (ii) esters of oleic acid with long-chain aliphatic alcohols in the range C₂₂−C₂₈ and (iii) benzyl alcohol esters of the very long-chain saturated fatty acids C₂₆ and C₂₈. The analysis and the structure assignments were carried out by gas chromatography coupled with mass spectrometry and by comparison with synthetic authentic model compounds. This work provided precise data on the chemical nature of the wax esters present in olive oil and should represent a means to detect adulteration of higher-grade olive oil with less expensive pomace olive oil and seed oils.     

LORETO: a tool for reducing state explosion in verification of LOTOS programs

LOTOS is a formal specification language for concurrent and distributed systems. Basic LOTOS is the version of LOTOS without value‐passing. A widely used approach to the verification of temporal properties is model checking. Often, in this approach the formal specification is translated into a labeled transition system on which formulae expressing properties are checked. A problem with this verification technique is state explosion: concurrent systems are often represented by automata with a prohibitive number of states. In this paper we show how, given a set ρ of actions, it is possible to automatically obtain for a Basic LOTOS program a reduced transition system to which only the arcs labeled by actions in ρ belong. The set ρ of actions plays a fundamental role in conjunction with a temporal logic defined by the authors in a previous paper: selective mu‐calculus. The reduced system with respect to ρ preserves the truth value of all selective mu‐calculus formulae with actions from the set ρ. We act at both syntactic and semantic levels. From a syntactic point of view, we define a set of transformation rules obtaining a smaller program. On the semantic side, we define a non‐standard semantics which dynamically reduces the transition system during generation. We present a tool implementing both the syntactic and the semantic reduction. Copyright © 1999 John Wiley & Sons, Ltd.