Behavioral and subjective effects of D-amphetamine and modafinil in healthy adults.

Modafinil is indicated for the management of excessive daytime sleepiness; however, recent studies have examined a broad range of potential uses. Given that clinical uses of modafinil may be expanding, this study compared modafinil and d-amphetamine effects on subjective and performance measures. Across 11 sessions, 11 healthy adults were tested after oral doses of placebo (5 sessions), modafinil (1.75 mg/kg, 3.50 mg/kg, or 7.00 mg/kg), and d-amphetamine (0.035 mg/kg, 0.070 mg/kg, 0.140 mg/kg) under double-blind, randomized conditions. Assessments of cognitive performance and subjective effects were completed before drug administration, 30 min after drug administration, and at hourly intervals after drug administration for 5 hr. Modafinil increased ratings on the Amphetamine and Morphine Benzedrine Group scales of the Addiction Research Center Inventory (ARCI) and increased ratings on the Vigor and Total Positive scales of the Profile of Mood States. d-Amphetamine increased visual analog ratings of feeling stimulated and liking the drug and increased ratings on the Morphine Benzedrine Group scale of the ARCI. Both medications significantly reduced visual analog scale ratings of feeling sleepy, and modafinil decreased ratings on the ARCI Pentobarbital-Chlorpromazine-Alcohol Group scale. Both medications sustained performance that deteriorated across time on the Sternberg Number Recognition Test. Modafinil also enhanced performance rate on the Digit-Symbol Substitution Task above baseline levels and increased response rate on the Repeated Acquisition of Response Sequences Task. These results suggest that modafinil engenders alerting effects and increases performance in healthy non-sleep-deprived individuals comparable with that of d-amphetamine. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans

Cyclamate and its metabolite cyclohexylamine affect male fertility in high dose animal studies, but this affect has not been investigated in epidemiological studies. This paper reports the first epidemiological study designed to investigate the possibility of a relationship between cyclamate and cyclohexylamine and male fertility in humans, in which 405 cases of clinically defined infertility in men and 379 controls were surveyed. Semen evaluation, urine analysis for cyclamate and cyclohexylamine and dietary questionnaires were compared between cases and controls. No evidence was found of a significant association between cyclamate intake and male infertility; neither high cyclamate nor high cyclohexylamine excretion were associated with elevated risk. The lack of association remained after adjusting by age, area of residence, education, total energy intake and other variables. No significant correlations were observed between cyclamate intake, metabolism or excretion, and sperm count and motility. The results demonstrate no effect of cyclamate or cyclohexylamine on male fertility at the present levels of cyclamate consumption.     

Perturbation technique for the finite element modelling of differential probes in non-destructive eddy-current testing

The paper deals with a new finite element scheme for non-destructive eddy-current testing (ECT) problems involving multiply connected test pieces and differential probes. It concerns a perturbation technique applied to the magnetodynamic h-phi formulation. The unperturbed field (in the absence of the flaw) is conventionally computed in the complete domain. The source of the perturbation problem is then determined by the projection of the unperturbed field in a relatively small region around the defect, the optimum size of which depends on the working frequency. The discretisation of this reduced domain is well adapted to the size of the defect and chosen independently of the dimensions of the excitation probe and the specimen under study. At a discrete level, the voltage change is efficiently computed by integration only over the defect and a layer of elements in the reduced domain that touches the defect's boundary. The accuracy of the proposed perturbation model is illustrated by comparison of the results obtained for different dimensions of the reduced domain with those achieved in the conventional way. The considered test case involves a differential probe scanning the outer surface of a metal tube for the detection of through-wall cracks     

Air flow through a non-airconditioned bus with open windows

Open window buses without air-conditioning are a major mode of urban and inter-city transport in most countries. High occupancy combined with hot and humid conditions makes travel in these buses quite uncomfortable. In this study air flow through a bus has been studied that could be the basis for low cost and eco-friendly methods of increasing passenger comfort and possibly reduce drag. The aerodynamics of such a road vehicle has not been studied as previous investigations have been confined to vehicles with closed windows that present a smooth exterior to air flow. Using a 1:25 scaled Perspex model of an urban bus in Delhi, flow visualization was performed in a water channel. The Reynolds numbers were one-tenth of a real bus moving at 10 m/s. Smoke and tuft visualizations were also performed on an urban bus at 40 km/h. Numerical simulations were performed at the actual Reynolds number. Even though there were Reynolds number differences, the broad features were similar. Air enters the bus from the rear windows, moves to the front (relative to the bus) and exits from the front windows. Inside air velocity relative to the bus is about one-tenth of the free-stream velocity. The flow is highly three-dimensional and unsteady.     

Local Structure and Valence State of Mn in Ga1−x Mn x N Epilayers

Mn has been incorporated in epilayers of the large-gap semiconductor GaN grown by molecular beam epitaxy using a nitrogen plasma cell. Detailed extended X-ray absorption fine structure (EXAFS) studies of a Ga_0.98Mn_0.02N epilayer confirm that the Mn atoms substitute the Ga atoms, with an increase by 2.7% of the distance to the nearest nitrogen atoms. Near-edge spectroscopy results tend to indicate that the valence state of Mn is slightly higher than 3+, while EXAFS analysis suggests an electron transfer to the N neighbors.