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11.
VN Dobrovolsky OV Lagutin TV Vinogradova IS Frolova VP Kuznetsov OA Larionov 《Canadian Metallurgical Quarterly》1993,319(1-2):181-184
Transgenic mice carrying a hybrid gene consisting of ovine beta-lactoglobulin gene sequences and human gamma-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800 IU/ml. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male. 相似文献
12.
JR Henkel G Apodaca Y Altschuler S Hardy OA Weisz 《Canadian Metallurgical Quarterly》1998,9(9):2477-2490
The function of acidification along the endocytic pathway is not well understood, in part because the perturbants used to modify compartmental pH have global effects and in some cases alter cytoplasmic pH. We have used a new approach to study the effect of pH perturbation on postendocytic traffic in polarized Madin-Darby canine kidney (MDCK) cells. Influenza M2 is a small membrane protein that functions as an acid-activated ion channel and can elevate the pH of the trans-Golgi network and endosomes. We used recombinant adenoviruses to express the M2 protein of influenza virus in polarized MDCK cells stably transfected with the polymeric immunoglobulin (Ig) receptor. Using indirect immunofluorescence and immunoelectron microscopy, M2 was found to be concentrated at the apical plasma membrane and in subapical vesicles; intracellular M2 colocalized partly with internalized IgA in apical recycling endosomes as well as with the trans-Golgi network marker TGN-38. Expression of M2 slowed the rate of IgA transcytosis across polarized MDCK monolayers. The delay in transport occurred after IgA reached the apical recycling endosome, consistent with the localization of intracellular M2. Apical recycling of IgA was also slowed in the presence of M2, whereas basolateral recycling of transferrin and degradation of IgA were unaffected. By contrast, ammonium chloride affected both apical IgA and basolateral transferrin release. Together, our data suggest that M2 expression selectively perturbs acidification in compartments involved in apical delivery without disrupting other postendocytic transport steps. 相似文献
13.
14.
Olga Shilova Elena Shramova Galina Proshkina Sergey Deyev 《International journal of molecular sciences》2021,22(9)
Cancer cells frequently overexpress specific surface receptors providing tumor growth and survival which can be used for precise therapy. Targeting cancer cell receptors with protein toxins is an attractive approach widely used in contemporary experimental oncology and preclinical studies. Methods of targeted delivery of toxins to cancer cells, different drug carriers based on nanosized materials (liposomes, nanoparticles, polymers), the most promising designed light-activated toxins, as well as mechanisms of the cytotoxic action of the main natural toxins used in modern experimental oncology, are discussed in this review. The prospects of the combined therapy of tumors based on multimodal nanostructures are also discussed. 相似文献
15.
The case of a quadricuspid aortic valve diagnosed in adult age is reported. A 67-year-old patient, who had no previous diseases or cardiovascular complaints, presented in the clinic for an embolic occlusion of the left retinal artery. Isolated moderate aortic regurgitation was diagnosed clinically and echocardiographically. For its further evaluation and for seeking embolic sources, multiplane transesophageal echocardiography was performed, which discovered a quadricuspid aortic valve as the cause of aortic regurgitation and major atherosclerotic lesions in the ascending aorta and the aortic arch as possible cause of the embolic event. The fourth, accessory cusp, smaller than the other three, was localized between the non-coronary and left coronary cusp. In the short axis view the quadricuspid aortic valve showed in diastole a "X"-configuration, with a persistent central orifice between the commissures, which was the cause of the regurgitation jet in color Doppler examination, and in the systole a trapezoid opening pattern. In the long-axis view the valve showed a tricuspid closing pattern. The quadricuspid aortic valve can be exactly diagnosed by multiplane transesophageal echocardiography. 相似文献
16.
It has been established that hippocampus, enthorhinal cortex, amygdala and substantia nigra (pars reticulata) lesions before head injury lead to a decrease of kainic acid-induced behavioral and electrographic seizure expressions. It can be concluded that after head injury the activation of limbic structures excitability due to excitation of "inputs" to these formations takes place. The obtained data indicate the significant role of nucleus caudatus in activation of posttraumatic brain excitatory mechanisms. 相似文献
17.
Yury I. Lyakhovetsky Elena A. Shilova Boris L. Tumanskii Alexander V. Usatov Era A. Avetisyan Sergei R. Sterlin 《Fullerenes, Nanotubes and Carbon Nanostructures》2013,21(2):263-287
Abstract Both [60]- and [70]fullerene react with either the Scherer radical (perfluorodiisopropylethylmethyl, C9F19), a mixture of branched perfluorononenes (C9F18, the product of hexafluoropropene trimerization), or β-fluorosulphatotetrafluoroethyldiheptafluoroisopropylmethyl radical (C9F18OSO2F) in the ionization chamber of a mass spectrometer to give the positive parent ions of trifluoromethylation products, the reaction being accompanied by hydrogen addition. The reaction occurs at least partly on the walls of the ionization chamber, by a radical mechanism employing CF3 radicals formed from the radical reactants both thermally and under electron impact; only the latter route occurs with the perfluorononenes. 相似文献
18.
A survey is presented of the so-called program schemata technique for proving the decidability of propositional program logics. This method is based on the reduction to versions of the problem of relative totality for nondeterministic Yanov schemata. 相似文献
19.
Mjakin S. V. Kovalenko A. S. Panova G. G. Shilova O. A. 《Glass Physics and Chemistry》2022,48(1):69-71
Glass Physics and Chemistry - It is shown that the deposition of silica sol shells on the surface of barley seeds based on hydrolyzed tetraethoxysilane with the addition of γ-Fe2O3 (maghemite)... 相似文献
20.
N.?Yu.?Koval’koEmail author M.?V.?Kalinina A.?N.?Malkova S.?A.?Lermontov L.?V.?Morozova I.?G.?Polyakova O.?A.?Shilova 《Glass Physics and Chemistry》2017,43(4):368-375
The technology of liquid-phase synthesis of mesoporous xerogels and aerogels based on ZrO2–Y2O3–CeO2 is developed. Xerogels are obtained by the coprecipitation of hydroxides, while aerogels are obtained in accordance with the sol–gel technology: the average pore size is 1.5–17.2 nm and the specific surface area is 120–878 m2/g. Aerogels are characterized by a high degree of porosity: the pore volume attains 1–4 cm3/g. Based on precursor xerogels, nanopowders of a tetragonal solid solution of the (ZrО2)0.92(Y2О3)0.03(CeО2)0.05 composition with a particle size of 5–9 nm and S spec = 74 m2/g were fabricated. Due to the high values of their specific surface area, the synthesized xerogels and aerogels are promising as sorbents, catalysts, or catalyst supports. 相似文献