Degradation and Mechanical Behavior of Fish Gelatin/Polycaprolactone AC Electrospun Nanofibrous Meshes

With the increasing interest in biopolymer nanofibers for diverse applications, the characterization of these materials in the physiological environment has become of equal interest and importance. This study performs first-time simulated body fluid (SBF) degradation and tensile mechanical analyses of blended fish gelatin (FGEL) and polycaprolactone (PCL) nanofibrous meshes prepared by a high-throughput free-surface alternating field electrospinning. The thermally crosslinked FGEL/PCL nanofibrous materials with 84–96% porosity and up to 60 wt% PCL fraction demonstrate mass retention up to 88.4% after 14 days in SBF. The trends in the PCL crystallinity and FGEL secondary structure modification during the SBF degradation are analyzed by Fourier transform infrared spectroscopy. Tensile tests of such porous, 0.1–2.2 mm thick FGEL/PCL nanofibrous meshes in SBF reveal the ultimate tensile strength, Young's modulus, and elongation at break within the ranges of 60–105 kPa, 0.3–1.6 MPa, and 20–70%, respectively, depending on the FGEL/PCL mass ratio. The results demonstrate that FGEL/PCL nanofibrous materials prepared from poorly miscible FGEL and PCL can be suitable for selected biomedical applications such as scaffolds for skin, cranial cruciate ligament, articular cartilage, or vascular tissue repair.     

Minimization of free radical damage by metal catalysis of multivitamin/multimineral supplements

Multivitamin/multimineral complexes are the most common dietary supplements. Unlike minerals in foods that are incorporated in bioorganic structures, minerals in dietary supplements are typically in an inorganic form. These minerals can catalyze the generation of free radicals, thereby oxidizing antioxidants during digestion. Here we examine the ability of a matrix consisting of an amino acid and non-digestible oligosaccharide (AAOS) to blunt metal-catalyzed oxidations. Monitoring of ascorbate radical generated by copper shows that ascorbate is oxidized more slowly with the AAOS matrix than with copper sulfate. Measurement of the rate of oxidation of ascorbic acid and Trolox^® by catalytic metals confirmed the ability of AAOS to slow these oxidations. Similar results were observed with iron-catalyzed formation of hydroxyl radicals. When compared to traditional forms of minerals used in supplements, we conclude that the oxidative loss of antioxidants in solution at physiological pH is much slower when AAOS is present.     

A Note on the Garin-Lowry Model

It is the claim of this paper that urbanization, long blamed for the ills of underdevelopment, is in fact an important development tool. The positive characteristics of urbanization and the dynamics by which it creates development are suggested by the communications model of social development. Based upon this model, a general strategy of national development is outlined. Appropriate economic policies, social policies, and political actions are suggested. These are illustrated by past experiences and current conditions in Latin America and other parts of the developing world.     

WHEN LESS IS MORE: EXPERIMENTAL EVIDENCE FOR TENACITY ENHANCEMENT BY DIVISION OF CONTACT AREA

Most recent data on hairy systems demonstrated their excellent adhesion and high reliability of contact. In contrast to smooth systems, some hairy systems seem to operate with dry adhesion and do not require supplementary fluids in the contact area. Contacting surfaces in such devices are subdivided into patterns of micro- or nanostructures with a high aspect ratio (setae, hairs, pins). The size of single points gets smaller and their density gets higher as the body mass increases. Previous authors explained this general trend by applying the JKR theory, according to which splitting up the contact into finer subcontacts increases adhesion. Fundamental importance of contact splitting for adhesion on smooth and rough substrata has been previously explained by a very small effective elastic modulus of the fibre array. This article provides the first experimental evidence of adhesion enhancement by division of contact area. A patterned surface made out of polyvinylsiloxane (PVS) has significantly higher adhesion on a glass surface than a smooth sample made out of the same material. This effect is even more pronounced on curved substrata. An additional advantage of patterned surfaces is the reliability of contact on various surface profiles and the increased tolerance to defects of individual contacts.     

Reliability study of AlTi/TiW on polysilicon contacts for high temperature sensors

This paper deals with the reliability of metal on polysilicon gauges for sensors operating in harsh environments. Particular test structures and characterization equipment have been developed in order to study AlTi/TiW on highly doped polysilicon contact resistance behaviour and long-term stability. Finite element modeling of current density distribution over the test structures allowed accurate contact resistance extraction. Contact resistance was found to be temperature dependent, having relative good long term stability at 150°C with a slight (lower than 10%) trend of increase.     

IR and UV laser-assisted deposition from titanium tetrachloride: A comparative study

Laser-induced TiCl₄ decomposition at vapour pressure was performed and comparative study of the composition and structure of thermally (at 10.6 μm) and photolytically (at 248 nm) deposited Ti-based films is presented. Emphasis was given to the less explored titanium deposition process by CO₂ laser pyrolysis of TiCl₄. The detailed structure of films deposited on quartz substrates was examined by scanning electron microscopy and X-ray photoelectron spectroscopy. The influence of the incident laser energy on the chemical content of the films as well as on the film growth rate was demonstrated. The results indicate that in the thermal IR decomposition of TiCl₄ a multilayer structure is formed with unsaturated TiSi_x at the interface and oxidized phases at the surface. The photolytic process leads to films with increased purity and a specific growth morphology.     

Efficiency of naphthalene biodegradation by Pseudomonas putida G7 in soil

The efficiency of naphthalene degradation by Pseudomonas putida G7 in soil was assessed using a mathematical model. The number of microorganisms and the concentration of naphthalene in soil samples were monitored. The feasibility of a spectrofluorometric method for naphthalene assay in soil samples was compared with high pressure liquid chromatography. A proposed mathematical model described the growth of the naphthalene‐degrading strains and the consumption of substrates (naphthalene, naphthalene degradation intermediates and soil organic substances) in soil. To describe the growth kinetics of microorganisms having high affinity to substrates with low solubility, two differential equations with substrate exponent 2/3 were proposed. These equations were used to describe utilization of soil organic matter. The model parameters characterize the growth rates for different substrates and respective yield coefficients, specific bacterial death and adaptation rates, and also the rates of PAHs degradation and evaporation. These characteristics can be used in choosing the bacterial strains for biopreparations and efficient clean‐up biotechnology of polluted soils. Copyright © 2004 Society of Chemical Industry     

Standby supply voltage minimization for deep sub-micron SRAM

Suppressing the leakage current in memories is critical in low-power design. By reducing the standby supply voltage (V_DD) to its limit, which is the data retention voltage (DRV), leakage power can be substantially reduced. This paper models the DRV of a standard low leakage SRAM module as a function of process and design parameters, and analyzes the SRAM cell stability when V_DD approaches DRV. The DRV model is verified using simulations as well as measurements from a 4 KB SRAM chip in a 0.13 μm technology. Due to a large on-chip variation, DRV of the 4 KB SRAM module ranges between 60 and 390 mV. Measurements taken at 100 mV above the worst-case DRV show that reducing the SRAM standby V_DD to a safe level of 490 mV saves 85% leakage power. Further savings can be achieved by applying DRV-aware SRAM optimization techniques, which are discussed at the end of this paper.     

Securing interaction between threads and the scheduler in the presence of synchronization

The problem of information flow in multithreaded programs remains an important open challenge. Existing approaches to specifying and enforcing information-flow security often suffer from over-restrictiveness, relying on nonstandard semantics, lack of compositionality, inability to handle dynamic threads, inability to handle synchronization, scheduler dependence, and efficiency overhead for the code that results from security-enforcing transformations. This paper suggests a remedy for some of these shortcomings by developing a novel treatment of the interaction between threads and the scheduler. As a result, we present a permissive noninterference-like security specification and a compositional security type system that provably enforces this specification. The type system guarantees security for a wide class of schedulers and provides a flexible and efficiency-friendly treatment of dynamic threads.