Superconductor Stability Revisited: Impacts from Coupled Conductive and Thermal Radiative Transfer in the Solid

Standard stability calculations following the Stekly, adiabatic or dynamic stability models apply purely solid thermal conduction mechanism, derive predictions under (quasi-) stationary and adiabatic conditions and assume ideal (mostly centrosymmetric) location of disturbances. Instead, the present paper takes into account also thermal radiative heat transfer in the superconducting solid, pool boiling, and considers the impact of random location and intensity of disturbances on the stability problem. The analysis is based on interplay between Monte Carlo radiative transfer calculations and a rigorous Finite Element method to calculate the resulting transient temperature field and stability functions. The combined Monte Carlo/Finite Element method is applied to 1G filament and 2G thin-film-coated high temperature superconductors. Results are strongly different from solutions achieved with standard, solely solid conduction thermal transport. It is not realistic, even in thin films, to assume uniform conductor temperature under transient disturbances. This may have significant consequences for design and simulation of performance of superconducting fault current limiters. There are doubts whether superconducting fault current limiters under any operation conditions could work in either pure flux flow or Ohmic resistive states.     

Transport and recombination in solar cells: New perspectives

The functioning of the solar cells relies on the photo-generation of carriers in p–n junctions and their subsequent recombination in the quasi-neutral regions. A number of basic issues concerning the physics of the operation of solar cells still remain obscure. This paper reports on some unsolved basic problems, namely: a model of the recombination processes that does not contradict Maxwell's equations; the role played by space charges in the transport phenomena, and the formation of quasi-neutral regions under the presence of non-equilibrium photo-generated carriers. In this work, a new formulation of the theory that explains the underlying physical phenomena involved in the generation of a photo-e.m.f. is presented.     

Influence of Boundaries on Shear-driven Flow of Liquids in Open Cavities

In recent years, the development of two-phase flow cooling systems in micro-electronic as well as surface coating/patterning technologies, often based on thin films and liquid filled micro-enclosures, has renewed the interest in the classical problem of the cavity flow driven by a shear stress imposed at the gas-liquid boundary. In this paper, we study, numerically, the influence of the cavity geometry and boundaries on the three dimensional velocity field driven by a shear flow of inert gas. This study has been performed in the frame of the ESA sponsored Space Program on heat and mass transfer CIMEX-1 and it has to be considered as a contribution in the preparation of the Space experiment. The reference values for the flow parameters as well as the geometrical features encountered in the present paper target the main features of the CIMEX-1 experiment, although the main conclusions can be considered of general validity.     

Control of the fluorescence of dye-antibody conjugates by (2-hydroxypropyl)-β-cyclodextrin in fluorescence microscopy and flow cytometry

When proteins are conjugated to fluorescent organic dyes, fluorescence emission of the dye molecules is usually decreased, sometimes up to 50-70%. This quenching phenomenon has been acknowledged for decades, but as yet, there are no simple, practical methods to control the fluorescence of dyes conjugated to proteins, especially for dyes conjugated to immunoglobulins. Here, we report that the addition of (2-hydroxypropyl)-β-cyclodextrin (HPβCD) to dye-antibody conjugates can increase fluorescence up to 2.5-fold in cell imaging and flow analysis. This method may be an effective way to increase the sensitivity of detection of fluorescent organic labels used in immunology, histochemistry, and cell biology.     

Angular diagram of broadband emission of millimeter-sized water droplets exposed to gigawatt femtosecond laser pulses

We report on the experiments on the interaction of gigawatt femtosecond laser pulses with suspended millimeter-sized water droplets. The transparent droplets experienced laser-induced breakdown and explosive boiling up and emitted a broadband radiation. This radiation covers the spectral range from 450 to 1100?nm and consists of the spectrum of laser pulse scattered and transformed by the droplet due to self-phase modulation and plasma emission produced in water during photoionization. The droplet emission spectrum showed remarkable broadening at all viewing angles and is maximal in the direction of the laser exit from the droplet. The enlargement of the droplet results in additional spectral spreading of the emitted radiation. The depth and amount of laser pulse spectral self-transformations upon propagation through the water droplet are simulated by means of numerical calculations.     

Peculiarities of Neurostimulation by Intense Nanosecond Pulsed Electric Fields: How to Avoid Firing in Peripheral Nerve Fibers

Intense pulsed electric fields (PEF) are a novel modality for the efficient and targeted ablation of tumors by electroporation. The major adverse side effects of PEF therapies are strong involuntary muscle contractions and pain. Nanosecond-range PEF (nsPEF) are less efficient at neurostimulation and can be employed to minimize such side effects. We quantified the impact of the electrode configuration, PEF strength (up to 20 kV/cm), repetition rate (up to 3 MHz), bi- and triphasic pulse shapes, and pulse duration (down to 10 ns) on eliciting compound action potentials (CAPs) in nerve fibers. The excitation thresholds for single unipolar but not bipolar stimuli followed the classic strength–duration dependence. The addition of the opposite polarity phase for nsPEF increased the excitation threshold, with symmetrical bipolar nsPEF being the least efficient. Stimulation by nsPEF bursts decreased the excitation threshold as a power function above a critical duty cycle of 0.1%. The threshold reduction was much weaker for symmetrical bipolar nsPEF. Supramaximal stimulation by high-rate nsPEF bursts elicited only a single CAP as long as the burst duration did not exceed the nerve refractory period. Such brief bursts of bipolar nsPEF could be the best choice to minimize neuromuscular stimulation in ablation therapies.     

Nanocarriers for Biomedicine: From Lipid Formulations to Inorganic and Hybrid Nanoparticles

Encapsulation of cargoes in nanocontainers is widely used in different fields to solve the problems of their solubility, homogeneity, stability, protection from unwanted chemical and biological destructive effects, and functional activity improvement. This approach is of special importance in biomedicine, since this makes it possible to reduce the limitations of drug delivery related to the toxicity and side effects of therapeutics, their low bioavailability and biocompatibility. This review highlights current progress in the use of lipid systems to deliver active substances to the human body. Various lipid compositions modified with amphiphilic open-chain and macrocyclic compounds, peptide molecules and alternative target ligands are discussed. Liposome modification also evolves by creating new hybrid structures consisting of organic and inorganic parts. Such nanohybrid platforms include cerasomes, which are considered as alternative nanocarriers allowing to reduce inherent limitations of lipid nanoparticles. Compositions based on mesoporous silica are beginning to acquire no less relevance due to their unique features, such as advanced porous properties, well-proven drug delivery efficiency and their versatility for creating highly efficient nanomaterials. The types of silica nanoparticles, their efficacy in biomedical applications and hybrid inorganic-polymer platforms are the subject of discussion in this review, with current challenges emphasized.     

Hypoxia in the Baltic Sea and basin-scale changes in phosphorus biogeochemistry

Deep-water oxygen concentrations in the Baltic Sea are influenced by eutrophication, but also by saltwater inflows from the North Sea. In the last two decades, only two major inflows have been recorded and the lack of major inflows is believed to have resulted in a long-term stagnation of the deepest bottom water. Analyzing data from 1970 to 2000 at the basin scale, we show that the estimated volume of water with oxygen, <2 mL L(-1), was actually at a minimum at the end of the longest so-called stagnation period on record. We also show that annual changes in dissolved inorganic phosphate water pools were positively correlated to the area of bottom covered by hypoxic water, but not to changes in total phosphorus load, thus addressing the legacy of eutrophication on a basinwide scale. The variations in phosphorus pools that have occurred during the past decades do not reflect any human action to reduce inputs. The long residence time and internally controlled variation of the large P pool in the Baltic Sea has important implications for management of both N and P inputs into this eutrophicated enclosed basin.