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11.
Für Krankenh?user sind Anwendungen für kooperativ angelegte Behandlungsprozesse wesentliche Werkzeuge um einen zeitnahen einrichtungs-
und sektorübergreifenden Austausch patientenbezogener medizinischer Daten zu gew?hrleisten. 相似文献
12.
RS Veazey DW Horohov JL Krahenbuhl HW Taylor JL Oliver TG Snider 《Canadian Metallurgical Quarterly》1995,47(1-2):79-87
Susceptibility of C57BL/6 (Bcgs) and C3H/HeN (Bcgr) mice to an intraperitoneal infection with Mycobacterium paratuberculosis strain 19698 was compared (by histopathology and the number of mycobacteria isolated from the spleen). Mycobacterial counts from the spleen of Bcgr mice progressively decreased over the course of infection but remained unchanged in Bcgs mice. Granulomatous lesions and acid-fast bacteria were consistently present in the liver and lymph nodes of Bcgs mice, whereas lesions were transient or absent in Bcgr mice. These results indicate that Bcgr mice are inherently resistant to M. paratuberculosis, whereas Bcgs mice are inherently susceptible. These differences may prove useful in elucidating the mechanisms of resistance and susceptibility to paratuberculosis and other mycobacterial infections. 相似文献
13.
14.
Pouria Pirzadeh Junichi Tatemura Oliver Po Hakan Hac?gümü? 《Journal of Grid Computing》2012,10(1):109-132
Recently there has been a considerable increase in the number of different Key-Value stores, for supporting data storage and
applications on the cloud environment. While all these solutions try to offer highly available and scalable services on the
cloud, they are significantly different with each other in terms of the architecture and types of the applications, they try
to support. Considering three widely-used such systems: Cassandra, HBase and Voldemort; in this paper we compare them in terms
of their support for different types of query workloads. We are mainly focused on the range queries. Unlike HBase and Cassandra
that have built-in support for range queries, Voldemort does not support this type of queries via its available API. For this
matter, practical techniques are presented on top of Voldemort to support range queries. Our performance evaluation is based
on mixed query workloads, in the sense that they contain a combination of short and long range queries, beside other types
of typical queries on key-value stores such as lookup and update. We show that there are trade-offs in the performance of
the selected system and scheme, and the types of the query workloads that can be processed efficiently. 相似文献
15.
Oliver Schoett 《Acta Informatica》1992,29(6-7):595-621
Two kinds of finite specification of the behaviour of a counter data type are proved impossible.We consider the class of data types (many-sorted algebras) behaving like an encapsulated counter that can be observed only by a test for zero. It is shown that no nonempty subclass of this class can be finitely specified in observational first-order logic, which is a variant of first-order logic in which equality may not be used on encapsulated types. Secondly, it is shown that the class cannot be described exactly by a finite specification in first-order logic.An extended abstract of a part of this paper appeared as: Schoett, O.: An observational subset of first-order logic cannot speacify the behaviour of a counter, in: Choffrut, C., Jantzen, M. (eds) STACS 91. 8th Annual Symposium on Theoretical Aspects of Computer Science (Lect. Notes comput. Sci., vol. 480, pp. 499–510) Berlin Heidelberg New York: Springer 1991 相似文献
16.
Lisa Goedtke Heike Sprenger Ute Hofmann Felix F. Schmidt Helen S. Hammer Ulrich M. Zanger Oliver Poetz Albrecht Seidel Albert Braeuning Stefanie Hessel-Pras 《International journal of molecular sciences》2021,22(1)
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants produced by incomplete combustion of organic matter. They induce their own metabolism by upregulating xenobiotic-metabolizing enzymes such as cytochrome P450 monooxygenase 1A1 (CYP1A1) by activating the aryl hydrocarbon receptor (AHR). However, previous studies showed that individual PAHs may also interact with the constitutive androstane receptor (CAR). Here, we studied ten PAHs, different in carcinogenicity classification, for their potential to activate AHR- and CAR-dependent luciferase reporter genes in human liver cells. The majority of investigated PAHs activated AHR, while non-carcinogenic PAHs tended to activate CAR. We further characterized gene expression, protein abundancies and activities of the AHR targets CYP1A1 and 1A2, and the CAR target CYP2B6 in human HepaRG hepatoma cells. Enzyme induction patterns strongly resembled the profiles obtained at the receptor level, with AHR-activating PAHs inducing CYP1A1/1A2 and CAR-activating PAHs inducing CYP2B6. In summary, this study provides evidence that beside well-known activation of AHR, some PAHs also activate CAR, followed by subsequent expression of respective target genes. Furthermore, we found that an increased PAH ring number is associated with AHR activation as well as the induction of DNA double-strand breaks, whereas smaller PAHs activated CAR but showed no DNA-damaging potential. 相似文献
17.
Oliver Schmutzler Sebastian Graf Nils Behm Wael Y. Mansour Florian Blumendorf Theresa Staufer Christian Krnig Dina Salah Yanan Kang Jan N. Peters Yang Liu Neus Feliu Wolfgang J. Parak Anja Burkhardt Elisabetta Gargioni Sabrina Gennis Sharah Chandralingam Finn Heg Wolfgang Maison Kai Rothkamm Florian Schulz Florian Grüner 《International journal of molecular sciences》2021,22(7)
Quantitative cellular in vitro nanoparticle uptake measurements are possible with a large number of different techniques, however, all have their respective restrictions. Here, we demonstrate the application of synchrotron-based X-ray fluorescence imaging (XFI) on prostate tumor cells, which have internalized differently functionalized gold nanoparticles. Total nanoparticle uptake on the order of a few hundred picograms could be conveniently observed with microsamples consisting of only a few hundreds of cells. A comparison with mass spectroscopy quantification is provided, experimental results are both supported and sensitivity limits of this XFI approach extrapolated by Monte-Carlo simulations, yielding a minimum detectable nanoparticle mass of just 5 pg. This study demonstrates the high sensitivity level of XFI, allowing non-destructive uptake measurements with very small microsamples within just seconds of irradiation time. 相似文献
18.
Suppression of the development of pores during laser-induced surface dispersion of TiC into aluminium, by means of a static magnetic field 总被引:1,自引:0,他引:1
A static magnetic field having the strength of B=0.6 T has been used as an additional process parameter in order to suppress the establishment of pores while dispersing TiC particles in surface layers of aluminium alloys using a laser. The migration of hydrogen towards regions of high temperatures within the melting pool can lead to the creation of gas bubbles, therefore yielding pores after resolidification in the processed layer. This mechanism (known for instance in welding technologies of aluminium) could be suppressed by Lorentz-forces induced by an externally applied magnetic field. It could be shown experimentally that magnetic fields could assist laser surface treatment processes beneficially if higher beam powers were coupled in. This may be interesting if, for instance, thicker dispersed layers should be achieved. 相似文献
19.
Oliver Warschkow Lj. Miljacic D. E. Ellis G. B. González T. O. Mason 《Journal of the American Ceramic Society》2006,89(2):616-619
We report first-principles density functional theory calculations of interstitial oxygen in tin-doped indium oxide (ITO), a transparent conducting oxide. Interstitial oxygen plays a critical role in the defect of ITO because it is by removal of interstitial oxygen that n -type charge carriers are produced. The Frank and Köstlin defect model successfully rationalizes the observed conductivity, Sn-doping, and oxygen partial pressure dependencies of ITO by postulating that tin atoms, which substitute for indium, are clustered with interstitial oxygen. Structural evidence for such a clustering, however, remains ambiguous. Recently published Rietveld refinement results of X-ray and neutron diffraction data found interstitial oxygen to be significantly displaced (0.4 Å) from the ideal fourfold position. Our calculations show that the experimental position is plausible only if interstitial oxygen is clustered with SnIn defects at any of the three d -type cation sites nearest to the interstitial, thereby providing direct structural confirmation of the Frank and Köstlin defect model. 相似文献
20.
Oliver R. Ilić 《Journal of Intelligent Manufacturing》2014,25(3):617-628
Manufacturing cell formation is the first step in the design of cellular manufacturing system. The primary objective of this step is to cluster machines into machine cells and parts into part families so that the minimum of intercell trips will be achieved. This paper will be focused on the configuration of machine cells considering three types of initial machine-part matrix: binary (zero-one) matrix, production volume matrix, and operation time matrix. The similarity measure uses only information from these types of matrix. A pure combinatorial programming formulation will be developed to maximize the sum of similarity coefficients between machine/part pairs. An e-Learning tool/application to help industrial students and engineers for enhancing their cell formation capability is proposed. This tool is designed to include a novel similarity coefficient-based heuristic algorithm for solving the cell formation problem. To determine the performance of the proposed tool, comparison is made with a well-known tool along a case study. 相似文献