Aligned nanofibres made of poly(3-hydroxybutyrate) grafted to hyaluronan for potential healthcare applications

In this work, a hybrid copolymer consisting of poly(3-hydroxybutyrate) grafted to hyaluronic acid (HA) was synthesised and characterised. Once formed, the P(3HB)-g-HA copolymer was soluble in water allowing a green electrospinning process. The diameters of nanofibres can be tailored by simply varying the M_w of polymer. The optimization of the process allowed to produce fibres of average diameter in the range of 100–150?nm and low polydispersity. The hydrophobic modification has not only increased the fibre diameter, but also the obtained layers were homogenous. At the nanoscale, the hybrid copolymer exhibited an unusual hairy topography. Moreover, the hardness and tensile properties of the hybrid were found to be superior compared to fibres made of unmodified HA. Particularly, this reinforcement was achieved at the longitudinal direction. Additionally, this work reports the use in the composition of a water-soluble copolymer containing photo cross-linkable moieties to produce insoluble materials post-electrospinning. The derivatives as well as their nanofibrous mats retain the biocompatibility of the natural polymers used for the fabrication.

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Surface and porous recast layer analysis in µ-EDM of MWCNT-Al2O3 composites

Machining of ceramic materials has been a major challenge owing to high hardness and brittleness. The reinforcement of a conducting filler allows permissible machining in electrical discharge machining (EDM) process. The current effort analyses the impact of multi-walled carbon nanotubes (MWCNT) of concentrations of 2.5 and 5 vol. %, as conducting filler towards machinability of alumina composites in µ-EDM process. The influence of tool materials and its rotation are closely analyzed. A successful machining process is observed in both the two composites, with a higher material removal rate (MRR) in 5 vol. % MWCNTs. When the tool starts to rotate at 750 rpm, an increment of around 60–65% is observed in MRR for both the two composites. Similarly, the surface roughness (R_a) decreases by a factor of 20?25%. The brass tool is observed to yield better machining capabilities due to the frequent initiation of sparks. A highly porous machined surface is observed in both the two composites. This scenario depicts the spalling effect as more dominant than melting-evaporation effect. The extent of porous recast layer on the drilled edges is found to reduce with increasing the speed of tool rotation.     

Comparison of test protocols for the standard room/corner test

As part of international efforts to evaluate alternative reaction‐to‐fire tests, several series of room/corner tests have been conducted. Materials tested were mostly different wood products but included gypsum board and a few foam plastics. This is a review of the overall results of related studies in which the different test protocols for the standard room/corner test were used. Differences in the test protocols involved two options for the ignition burner scenario and whether or not the ceiling was also lined with the test materials. The test materials were placed on three walls of the room in all the tests. The two burner scenarios were (1) 40 kW for 300 s followed by 160 kW for 300 s and (2) 100 kW for 600 s and 300 kW for 600 s. The 40 and 160 kW burner scenario without the ceiling lined did not provide a severe enough test for flashover to occur with fire‐retardant‐treated materials. Use of the 100 and 300 kW burner scenario without lining the ceiling provided the ability to differentiate between wood products with ASTM E 84 flame spread indexes of 70 to 125 and those with higher flame spread indexes. Lining the ceiling with test material creates a more severe test.     

Stability and rheology of dilute TiO<Subscript>2</Subscript>-water nanofluids

The apparent wall slip (AWS) effect, accompanying the flow of colloidal dispersions in confined geometries, can be an important factor for the applications of nanofluids in heat transfer and microfluidics. In this study, a series of dilute TiO₂ aqueous dispersions were prepared and tested for the possible presence of the AWS effect by means of a novel viscometric technique. The nanofluids, prepared from TiO₂ rutile or anatase nanopowders by ultrasonic dispersing in water, were stabilized by adjusting the pH to the maximum zeta potential. The resulting stable nanofluid samples were dilute, below 0.7 vol.%. All the samples manifest Newtonian behavior with the fluidities almost unaffected by the presence of the dispersed phase. No case of important slip contribution was detected: the Navier slip coefficient of approximately 2 mm Pa^-1 s^-1 would affect the apparent fluidity data in a 100-μm gap by less than 1%.     

Liquid Biopsy as a Source of Nucleic Acid Biomarkers in the Diagnosis and Management of Lynch Syndrome

Lynch syndrome (LS) is an autosomal dominant inherited cancer predisposition disorder, which may manifest as colorectal cancer (CRC), endometrial cancer (EC) or other malignancies of the gastrointestinal and genitourinary tract as well as the skin and brain. Its genetic cause is a defect in one of the four key DNA mismatch repair (MMR) loci. Testing of patients at risk is currently based on the absence of MMR protein staining and detection of mutations in cancer tissue and the germline, microsatellite instability (MSI) and the hypermethylated state of the MLH1 promoter. If LS is shown to have caused CRC, lifetime follow-up with regular screening (most importantly, colonoscopy) is required. In recent years, DNA and RNA markers extracted from liquid biopsies have found some use in the clinical diagnosis of LS. They have the potential to greatly enhance the efficiency of the follow-up process by making it minimally invasive, reproducible, and time effective. Here, we review markers reported in the literature and their current clinical applications, and we comment on possible future directions.     

如何为便携式多媒体处理器供电

引言在现代应用中,传统的低压降稳压器(LDO)正逐渐被开关电源(SMPS)所取代。虽然LDO是一个成本低廉而且强固耐用的电源解决方案,但是它耗电很大。越来越多的便携设备厂商,像数码相机、手机、PDA制造商,都在研究用效率更高的解决方案取代LDO的可行性。开关解决方案的大小,即电源的物理尺寸,通常是这些厂商无法逾越的障碍。STw4141是一个创新的开关电源,只使用一个外接线圈就能产生两个独立的输出电压。因为其内在的开关特性,这个芯片的效率很高,而且所需的外部组件数量极少。该产品的效率可以与两个独立的开关电源媲美,尺寸相当于两…     

Motion and growth of new-phase particles formed in a thermodiffusion chamber

The correlation between the growth and motion of new-phase particles in a thermodiffusion chamber is theoretically investigated. The results are compared with experimental data.Translated from Inzhenerno-Fizicheskii Zhurnal, Vol. 56, No. 6, pp. 936–942, June, 1989.     

Determination of the diameter distribution of single-wall carbon nanotubes from the Raman G-band using an artificial neural network

A novel, artificial neural network-based method is now available for obtaining the mean diameter of single wall carbon nanotube (SWCNT) samples from the diameter dispersive features of their Raman G-band. The method is demonstrated here for six different diameter SWCNT samples and 14 different excitation wavelengths. With an adequately large pool of standard nanotube samples, the suggested method is a useful complementary technique for SWCNT diameter analysis as it is capable of rapid diameter evaluation without prior knowledge of the relevant phonon dispersion relations.     

Leaching of APC residues from secondary Pb metallurgy using single extraction tests: the mineralogical and the geochemical approach

Two air-pollution-control (APC) residues--one from flue gas cooling with alkaline water and one from deionized water cooling--from secondary lead metallurgy were submitted to two different standardized short-term leaching protocols: US EPA toxicity characteristic leaching procedure (TCLP) and static leaching according to Czech/European norm EN 12457-2. The experimental procedure was coupled with detailed mineralogical investigation of the solid material (SEM, XRPD) and speciation-solubility calculations using the PHREEQC-2 geochemical code. Both types of residues were considered as hazardous materials exhibiting substantial leaching of Pb (up to 7130 mg/l) and other inorganic contaminants. However, the APC residue produced by flue gas cooling with alkaline water (sample B) exhibits more favourable leaching and environmental characteristics than that produced by simple deionised water cooling (sample A). At pH < 5, primary caracolite (Na3Pb2(SO4)3Cl) and potassium lead chloride (KCl.2PbCl2) are completely or partially dissolved and transformed to residual anglesite (PbSO4), cotunnite (PbCl2) and laurionite (Pb(OH)Cl). At pH 5-6, anglesite is still the principal residual product, whereas at pH > 6, phosgenite (PbCl2.PbCO3) became the dominant secondary phase. The results are consistent with the mineralogical and geochemical studies focused on acidic forest soils highly polluted by smelter emissions, where anglesite, as a unique Pb-bearing phase, has been detected. From the technological point of view, the mixing of APC residue with alkaline water, followed by an increase in the suspension pH and equilibration with atmospheric CO2, may be used to ensure the precipitation of less soluble Pb carbonates, which are more easily recycled in the Pb recovery process in the metallurgical plant.