Kinetics of Ion-Pair Absorption

According to the 'pH-partition' theory, drugs in their ionized form cannot readily diffuse through biological membrane. However, it is well known that the permeation of many ionized drugs can be enhanced by the presence of anionic or cationic agents. One of the explanations for this observation is that the charged molecules of drug interact with the agents and form lipophillic ion-pair species, and as a result, the absorption of ionized molecules increases. In the present paper, the kinetic relationships of the formation of the ion-pair as a function of ion-pair agent and the type of the biological membrane have been discussed and analyzed. Criteria have been developed for the distinguishing the following two cases: 1) when the absorption is the rate limiting step in the process of permeation of the ion-pair, and 2) when the ion-pair crosses the membrane as though it were a fine sieve.     

Geothermal reservoir simulation

This paper is intended to be a state of the art review of geothermal reservoir simulation. Its recent application to the modelling of real geothermal reservoirs is described and put in the context of an emerging general approach to reservoir modelling. The use of computer simulation for geothermal well test analysis is described. One of the main recent uses of reservoir simulators has been for conducting numerical experiments aimed at improving the understanding of geothermal reservoir physics. Such studies on fractured reservoirs, the thermal structure of reservoirs and the effects of non-condensable gases and dissolved salts are outlined.     

Thirty years later: Attitudes toward the employment of older workers.

Replicated W. K. Kirchner and M. D. Dunnette's (see record 1955-03161-001) study on attitudes toward older workers with 71 male and 5 female hourly employees (aged 18–61 yrs) and 22 male supervisors (aged 27–63 yrs) of a nonunion manufacturing plant. Ss completed a questionnaire that was nearly identical to the one administered in the Kirchner and Dunnette study. Results are similar to those obtained in the earlier study: Hourly workers held more positive attitudes toward older employees than did supervisors, and attitude score correlated strongly with the age of hourly workers but not with the age of supervisors. (9 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

WHIM, the Window Handler and Input Manager

This article describes WHIM, the Window Handler and Input Manager, a window management system being developed as part of the QuickSilver operating system project at IBM's Almaden Research Center. Another version of WHIM runs under AIX on the IBM PC RT. This article contrasts and compares the overlapped window scheme used in WHIM with the tiled window scheme used in other systems. The advantages of the window management scheme used in WHIM are detailed, and the effect of display interfaces on the window manager is described.     

A Graphene Field-Effect Device

In this letter, a top-gated field-effect device (FED) manufactured from monolayer graphene is investigated. Except for graphene deposition, a conventional top-down CMOS-compatible process flow is applied. Carrier mobilities in graphene pseudo-MOS structures are compared to those obtained from the top-gated Graphene-FEDs. The extracted values exceed the universal mobility of silicon and silicon-on-insulator MOSFETs     

Modeling of anaerobic treatment of wastewater in ponds.

A mathematical model to simulate the performance of anaerobic ponds was developed incorporating both settling of particulate components and the biological anaerobic digestion process. The biological activity includes solubilization of particulate organic matter; methanogenesis and the sulphate reduction process. The model considers that an anaerobic pond comprises a series of equal size columns. Each column has three compartments viz. liquid layer, active sediment layer and inert sediment layer. The existence of organic matter and sulphate removal mechanisms both in the bulk as well as sediment layer of the ponds and the exchange of the soluble components between the layers has been included in the model. The model was transferred to a computer program using VisSim Basic software. The model was verified by comparing simulated results with full-scale as well as with laboratory-scale anaerobic pond performance data. A good agreement between the simulated and the observed pond performance was achieved.     

Multicriteria procedure for the design and the management of infiltration systems.

Infiltration systems are frequently used as an option to manage urban storm drainage. By reducing flows and volumes in downstream sewers or in surface waters, they decrease the overflows and make it possible to recharge groundwater. They come in various forms with different uses; therefore, their performance is diverse and integrates multiple aspects. Consequently, a multicriteria approach was developed in order to quantify the performance of these systems and to help in decision making problems. For that purpose, a list of performance indicators integrating technical, economical, environmental and social aspects was developed. The performances were defined with the help of a working group composed of engineers from different technical or strategic departments from Greater Lyon and researchers from different fields. The paper presents the last version of the performance indicators tested according to a set of quality requirements: availability of data, relevance, fidelity, precision, sensitivity/robustness. This critical review of the set of indicators has led us to redefine a certain number of indicators, identify numerous biases and allow putting forward general instructions for criterion or indicator construction. The last phase is to propose multicriteria decision aid methods; a procedure using ELECTRE methods should be used.