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61.
FH Wapstra H Van Goor G Navis PE De Jong D De Zeeuw 《Canadian Metallurgical Quarterly》1996,90(5):393-401
1. The mechanism of renal protection by angiotensin-converting enzyme inhibition is still the subject of debate. Inhibition of proteinuria might play a role. If so, a good antiproteinuric response to angiotensin-converting enzyme inhibition should predict subsequent protection against renal structural damage. This hypothesis has not been tested in models where treatment is started after the renal disease is well established, i.e. models that mimic the clinical situation. 2. We therefore investigated this hypothesis in 96 male Wistar rats with established adriamycin nephrosis. Reduction of proteinuria was achieved by lisinopril (0, 2, 5 and 10 mg day-1 kg-1) on two different sodium diets (0.3% and 0.05% NaCl). Therapy started 6 weeks after adriamycin (at stable proteinuria) and was continued for 6 weeks. 3. Lisinopril reduced blood pressure by 32 +/- 4% and proteinuria by an average of 72 +/- 7%, with stabilization after 2 weeks. Considerable interindividual differences in antiproteinuric response was found. Glomerulosclerosis score was reduced by 15 +/- 5%. All the effects of angiotensin-converting enzyme inhibitors were enhanced by sodium depletion, but sodium depletion in itself did not affect blood pressure (124 +/- 4 mmHg), proteinuria (664 +/- 68 mg/day) or glomerulosclerosis score (30 +/- 5%). Interestingly, the more proteinuria was reduced initially in an individual rat, the less sclerosis was found in the long term in that rat. 4. In conclusion, angiotensin-converting enzyme inhibition lowers proteinuria and prevents glomerulosclerosis in established adriamycin nephrosis. These effects are enhanced by sodium depletion. The individual short-term antiproteinuric effect predicts the protection against ultimate glomerular damage. This is consistent with the hypothesis that reduction of proteinuria is a mechanism by which angiotensin-converting enzyme inhibitors exert renoprotection. 相似文献
62.
Krick R.F. Clark L.T. Deleganes D.J. Wong K.L. Fernando R. Debnath G. Banik J. 《Solid-State Circuits, IEEE Journal of》1994,29(12):1455-1463
An implementation of the Pentium microprocessor architecture in 0.6 μm BiCMOS technology is described. Power dissipation is reduced and performance is enhanced over the previous generation. Processor features, implementation technology, and circuit techniques are discussed. An internal clock rate of 150 MHz is achieved at 3.7 V and -55°C 相似文献
63.
This paper examines the detrimental effects of excess majority carriers and photons induced by impact ionization on the operation of neighboring pn junctions, bipolar transistors, MOS transistors, and circuits. The experimental results show that in addition to an increase in the substrate surface potential due to the excess majority carriers, photons can lower the barrier of a pn junction and, as a consequence, shift the Gummel plot of an npn bipolar transistor. As for the neighboring circuits, an example in which the speed of an NMOS ring oscillator is retarded by impact ionization in a neighboring NMOS transistor is presented 相似文献
64.
High dielectric constant (high-k) polymer composites are of great interest for embedded capacitor applications. Previously,
we demonstrated that epoxy—aluminum composites are promising for embedded capacitor applications, because they have a high
dielectric constant and a low dielectric loss due to the core—shell structure of the self-passivated aluminum particles. In
this work, to further understand the dielectric behavior of aluminum composites, lower-loss polymers such as silicone, polyimide,
polynorbornene, and benzocyclobutene were explored as matrices for the aluminum composites. It is found that the polymer matrices
can significantly change the dielectric properties of the aluminum composites. A polymer matrix with a lower dielectric constant
generally results in a lower dielectric constant of its aluminum composites. In this regard, polymer—aluminum composites have
a similar dielectric characteristic as polymer—ceramic composites. Thermomechanical properties of aluminum composites were
characterized by a thermomechanical analyzer. 相似文献
65.
Kok Wai Wong Chun Che Fung Eren H. Gedeon T. 《IEEE transactions on instrumentation and measurement》2003,52(6):1865-1869
Fuzzy rule-based systems have been very popular in many engineering applications. In mineral engineering, fuzzy rules are normally constructed using some fuzzy rule extraction techniques to establish the determination model in predicting the d50c of hydrocyclones. However, when generating fuzzy rules from the available information, it may result in a sparse fuzzy rule base. The use of more than one input variable is also common in hydrocyclone data analysis. This paper examines the application of fuzzy interpolation to resolve the problems using sparse fuzzy rule bases, and to perform analysis of fuzzy interpolation in multidimensional input spaces. 相似文献
66.
PE McAndrew A Frostholm JE Evans D Zdilar D Goldowitz IM Chiu AH Burghes A Rotter 《Canadian Metallurgical Quarterly》1998,391(4):444-455
67.
A new colour quantisation and quadtree based image compression scheme is proposed. The features of the new scheme are that colour palette ordering and requantisation of the decoded image for palette-based monitor displays are not required. Thus, fast decoding and displaying can be achieved 相似文献
68.
Haus H.A. Khatri F.I. Wong W.S. Ippen E.P. Tamura K.R. 《Quantum Electronics, IEEE Journal of》1996,32(6):917-924
The interaction of a soliton of the Nonlinear Schrodinger Equation (NSE) with a weak sinusoidal wave packet is treated analytically. The second-order soliton solution containing the original soliton and a perturbing soliton is expanded to first order in the amplitude of the perturbating soliton. From this expansion, one obtains the associate function of Gordon (1992) and a continuous change of position and phase of the perturbed soliton. One finds that the soliton experiences a second-order change of velocity under the influence of the perturbation. This result is then used to derive the displacement due to a wave packet of general shape, which is also confirmed by computer simulation 相似文献
69.
The tail-flick (TF) technique was used to assess the antinociceptive properties of nifedipine (NIF) given intraperitoneally (i.p.). First, the most suitable intensity of the noxious stimulus (temperature of the bulb) has been ascertained and used in the main study. Male Sprague-Dawley rats received NIF, dissolved in dimethyl sulfoxide (DMSO) at the doses of 0.0, 0.5, 2, 5, 10 and 15 mg/kg, or control with no injection. For the main study, the noxious stimulus was limited to 15 sec (cut-off time) and TF latencies were recorded up to 120 min. The antinociceptive response was expressed as the area under the curve for each rat and analyzed by one-way ANOVA. The antinociceptive response to the lower doses of NIF (0.5 and 2 mg/kg) did not differ from control (no injection) and DMSO alone. Significance was found at 5, 10 and 15 mg NIF with no difference among the doses. However, there was an increasing tendency of the mean values from 0.5 to 15 mg NIF resulting in a positive correlation. The correlation coefficient was 0.32483 (p = 0.015) and regression equation Y = (19.37) x dose + 1320. Our data suggest that spinal mechanisms are involved in NIF-induced antinociception. 相似文献
70.