动态SVDD算法及其应用

针对当前SVDD算法由于过大的优化规模导致检测计算时间过长的问题,提出了动态SVDD算法.通过分析在进行检测工作时新加入检测对象对正域边界的影响,提出:采用核方法形成的边界可近似替代折线所形成的边界.这样,加入新检测对象后,新的边界就只与新的样本点和之前的边界有关,从而可以大大减小优化规模,提高检测的效率.     

时间自动机的LTL性质模型检测研究

为了增强模型检测工具的检测能力,拓宽模型检测技术的应用范围,对基于时间自动机的LTL性质模型检测进行了研究,对自动机的状态空间的存储方式和状态空间的展开过程进行了分析,讨论了LTL性质模型检测工具的检测流程和检测算法的实现策略对工具检测性能的影响,针对制约模型工具的检测能力和检测效率的因素,采取了一些相应的优化改进策略.采用了BDD(二叉决策图)共享存储技术和位编码压缩存储,较有效地减小了空间消耗,缓解了模型检测中状态爆炸引起的内存空间不足问题.与DTSpin等著名的模型检测工具进行了实验比较,取得了较好的实验结果.     

基于半实物仿真的电路板故障注入系统设计与实现

为了满足某型装备电路板测试性与诊断设计评价的需求,提出了一种基于DSP技术,利用半实物仿真方式实现的故障注入系统;该系统以TMS320C5416系列DSP器件为核心器件,利用CPLD扩展外部电路,主控计算机与该系统的通信通过USB接口实现,在故障注入时通过半实物仿真模式实现对电路板典型故障的注入;通过对典型电路的故障注入试验表明,该系统可靠性高,配置灵活,使用方便;目前该系统已经在工程实践中得到应用,效果明显,对提高电路板测试性设计水平具有重要意义。     

模糊控制在磁悬浮球系统实时控制中的应用

在磁悬浮球系统中采用PID控制时,动态性能较差,控制效果不理想.为了获得控制效果较好的控制器,根据模糊控制原理,设计磁悬浮模糊控制器.根据PID实时控制中的经验,确定模糊控制器的输入输出变量模糊化范围,建立合理的模糊规则表.在Matlab/Simulink中组建实时控制模块,并分别对磁悬浮球系统在无干扰和有干扰下进行实时控制.对控制效果进行分析讨论,证明模糊控制器具有良好的鲁棒性和在非线性系统控制中的有效性.     

基于改进的基因表达式编程算法在作业车间调度问题中的应用

文章提出一种新颖的方法一改进的基因表达式编程算法来求解作业车间调度问题。作业车间调度问题是许多实际生产调度问题的简化模型,基因表达式编程算法结合了遗传算法和遗传编程的优点,具有更强的解决问题能力,对基因表达式编程算法进行改进使其在作业车间调度问题的应用上更加有效;最后应用一个实例来验证提出方法的有效性。     

基于人工免疫的网络安全态势评估模型

本文将人工免疫原理应用到网络安全态势评估的研究中.通过对入侵检测模型中有关自体、非自体、抗原的形式化描述,建立了抗体细胞的演化机制、动态免疫记忆、免疫监视等免疫机制.依据人体免疫系统抗体浓度的变化与病原体入侵强度的对应关系,建立了网络安全态势实时定量计算模型.     

Macrophage Membrane-Coated Nanoparticles Sensitize Glioblastoma to Radiation by Suppressing Proneural–Mesenchymal Transformation in Glioma Stem Cells

Radiotherapy is identified as a crucial treatment for patients with glioblastoma, but recurrence is inevitable. The efficacy of radiotherapy is severely hampered partially due to the tumor evolution. Growing evidence suggests that proneural glioma stem cells can acquire mesenchymal features coupled with increased radioresistance. Thus, a better understanding of mechanisms underlying tumor subclonal evolution may develop new strategies. Herein, data highlighting a positive correlation between the accumulation of macrophage in the glioblastoma microenvironment after irradiation and mesenchymal transdifferentiation in glioblastoma are presented. Mechanistically, elevated production of inflammatory cytokines released by macrophages promotes mesenchymal transition in an NF-κB-dependent manner. Hence, rationally designed macrophage membrane-coated porous mesoporous silica nanoparticles (MMNs) in which therapeutic anti-NF-κB peptides are loaded for enhancing radiotherapy of glioblastoma are constructed. The combination of MMNs and fractionated irradiation results in the blockage of tumor evolution and therapy resistance in glioblastoma-bearing mice. Intriguingly, the macrophage invasion across the blood-brain barrier is inhibited competitively by MMNs, suggesting that these nanoparticles can fundamentally halt the evolution of radioresistant clones. Taken together, the biomimetic MMNs represent a promising strategy that prevents mesenchymal transition and improves therapeutic response to irradiation as well as overall survival in patients with glioblastoma.     

Comparison of gas sensing properties based on hollow and porous α-Fe<Subscript>2</Subscript>O<Subscript>3</Subscript> nanotubes

Hollow and porous α-Fe₂O₃ nanotubes were successfully synthesized by single nozzle electrospinning method followed by annealing treatment. The crystal structures and morphologies of the as-prepared materials were characterized by X-ray diffraction and scanning electron microscopy, respectively. The as-prepared materials were applied to construct gas sensor devices which gas sensing properties were further investigated. The obtained results revealed that porous α-Fe₂O₃ nanotube gas sensors exhibit a markedly enhanced gas sensing performance compared with hollow α-Fe₂O₃ nanotube gas sensors, which was about three times higher to 100 ppm acetone at 240 °C. Interestingly, hollow and porous α-Fe₂O₃ nanotube gas sensors both showed fast response–recovery time and good selectivity, but the porous ones possessed the shorter recovery time. The improved properties could be attributed to the unique morphology of porous nanotubes. Thus, further improvement of performance in metal-oxide-semiconductors materials could be realized by preparation the unique porous structures of nanotubes. Moreover, it is expected that porous metal-oxide-semiconductors nanotubes could be further design as promising candidates for gas sensing materials.