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111.
Pablo J. Giraudi Noel Salvoza Deborah Bonazza Carlo Saitta Daniele Lombardo Biagio Casagranda Nicol de Manzini Teresa Pollicino Giovanni Raimondo Claudio Tiribelli Silvia Palmisano Natalia Rosso 《International journal of molecular sciences》2022,23(5)
Fibrosis is the strongest predictor for disease-specific mortality in non-alcoholic fatty liver diseases (NAFLD), but the need for liver biopsy limits its diagnosis. We assessed the performance of plasma ficolin-2 (FCN-2) as a biomarker of fibrosis identified by an in silico discovery strategy. Two hundred and thirty-five morbidly obese (MO) subjects with biopsy-proven NAFLD stratified by fibrosis stage (F0, n = 44; F1, n = 134; F2, n = 46; F3/F4, n = 11) and 40 cirrhotic patients were enrolled. The cohort was subdivided into discovery (n = 76) and validation groups (n = 159). The plasma level of FCN-2 and other candidate markers was determined. FCN-2 was inversely correlated with the stage of liver fibrosis (ρ = −0.49, p < 0.001) independently of steatosis (p = 0.90), inflammation (p = 0.57), and ballooning (p = 0.59). In the global cohort, FCN-2 level decreased significantly in a stepwise fashion from F0/F1 (median 4753 ng/mL) to F2–F3–F4 (2760 ng/mL) and in cirrhotic subjects (1418 ng/mL). The diagnostic performance of FCN-2 in detecting F ≥ 2 was higher than other indexes (APRI, FIB-4) (AUROC 0.82, 0.68, and 0.6, respectively). The accuracy improved when combined with APRI score and HDL values (FCNscore, AUROC 0.85). Overall, the FCN-2 plasma level can accurately discriminate liver fibrosis status (minimal vs. moderate/advanced) significantly improving the fibrosis diagnostic algorithms. 相似文献
112.
Pablo Salcedo-Abraira Sergio M.F.Vilela Artem A.Babaryk Maria Cabrero-Antonino Pedro Gregorio Fabrice Salles Sergio Navalon Hermenegildo Garcia Patricia Horcajada 《Nano Research》2021,14(2):450-457
A novel microporous two-dimensional(2D)Ni-based phosphonate metal-organic framework(MOF;denoted as IEF-13)has been successfully synthesized by a simple and green hydrothermal method and fully characterized using a combination of experimental and computational techniques.Structure resolution by single-crystal X-ray diffraction reveals that IEF-13 crystallizes in the triclinic space group Pi having bi-octahedra nickel nodes and a photo/electroactive tritopic phosphonate ligand.Remarkably,this material exhibits coordinatively unsaturated nickel(II)sites,free-P03H2and-P03H acidic groups,a C02accessible microporosity,and an exceptional thermal and chemical stability.Further,its in-deep optoelectronic characterization evidences a photoresponse suitable for photocatalysis.In this sense,the photocatalytic activity for challenging H2generation and overall water splitting in absence of any co-catalyst using UV-Vis irradiation and simulated sunlight has been evaluated,constituting the first report for a phosphonate-MOF photocatalyst.IEF-13 is able to produce up to 2,200 fimol of H2per gram using methanol as sacrificial agent,exhibiting stability,maintaining its crystal structure and allowing its recycling.Even more,170μmol of H2per gram were produced using IEF-13 as photocatalyst in the absence of any co-catalyst for the overall water splitting,being this reaction limited by the 02reduction.The present work opens new avenues for further optimization of the photocatalytic activity in this type of multifunctional materials. 相似文献
113.
114.
Mark F. Pittenger Saman Eghtesad Pablo G. Sanchez Xiaoyan Liu Zhongjun Wu Ling Chen Bartley P. Griffith 《International journal of molecular sciences》2022,23(2)
Many clinical studies utilizing MSCs (mesenchymal stem cells, mesenchymal stromal cells, or multipotential stromal cells) are underway in multiple clinical settings; however, the ideal approach to prepare these cells in vitro and to deliver them to injury sites in vivo with maximal effectiveness remains a challenge. Here, pretreating MSCs with agents that block the apoptotic pathways were compared with untreated MSCs. The treatment effects were evaluated in the myocardial infarct setting following direct injection, and physiological parameters were examined at 4 weeks post-infarct in a rat permanent ligation model. The prosurvival treated MSCs were detected in the hearts in greater abundance at 1 week and 4 weeks than the untreated MSCs. The untreated MSCs improved ejection fraction in infarcted hearts from 61% to 77% and the prosurvival treated MSCs further improved ejection fraction to 83% of normal. The untreated MSCs improved fractional shortening in the infarcted heart from 52% to 68%, and the prosurvival treated MSCs further improved fractional shortening to 77% of normal. Further improvements in survival of the MSC dose seems possible. Thus, pretreating MSCs for improved in vivo survival has implications for MSC-based cardiac therapies and in other indications where improved cell survival may improve effectiveness. 相似文献
115.
Beukes Pierre C. Gregorini Pablo Cameron Keith Attwood Graeme T. 《Nutrient Cycling in Agroecosystems》2020,117(1):1-12
Nutrient Cycling in Agroecosystems - The nitrogen (N) fertilizer application rate (kg ha?1 year?1) in pastoral dairy systems affects the flow of N through the soil,... 相似文献
116.
Dr. Pablo Valverde J. Daniel Martínez Prof. F. Javier Cañada Dr. Ana Ardá Prof. Jesús Jiménez-Barbero 《Chembiochem : a European journal of chemical biology》2020,21(21):2999-3025
Carbohydrates play a pivotal role in intercellular communication processes. In particular, glycan antigens are key for sustaining homeostasis, helping leukocytes to distinguish damaged tissues and invading pathogens from healthy tissues. From a structural perspective, this cross-talk is fairly complex, and multiple membrane proteins guide these recognition processes, including lectins and Toll-like receptors. Since the beginning of this century, lectins have become potential targets for therapeutics for controlling and/or avoiding the progression of pathologies derived from an incorrect immune outcome, including infectious processes, cancer, or autoimmune diseases. Therefore, a detailed knowledge of these receptors is mandatory for the development of specific treatments. In this review, we summarize the current knowledge about four key C-type lectins whose importance has been steadily growing in recent years, focusing in particular on how glycan recognition takes place at the molecular level, but also looking at recent progresses in the quest for therapeutics. 相似文献
117.
Dr. Lei Huang Jan Philipp Bittner Dr. Pablo Domínguez de María Dr. Sven Jakobtorweihen Prof. Dr. Selin Kara 《Chembiochem : a European journal of chemical biology》2020,21(6):811-817
The use of oxidoreductases (EC1) in non-conventional reaction media has been increasingly explored. In particular, deep eutectic solvents (DESs) have emerged as a novel class of solvents. Herein, an in-depth study of bioreduction with an alcohol dehydrogenase (ADH) in the DES glyceline is presented. The activity and stability of ADH in mixtures of glyceline/water with varying water contents were measured. Furthermore, the thermodynamic water activity and viscosity of mixtures of glyceline/water have been determined. For a better understanding of the observations, molecular dynamics simulations were performed to quantify the molecular flexibility, hydration layer, and intraprotein hydrogen bonds of ADH. The behavior of the enzyme in DESs follows the classic dependence of water activity (aW) in non-conventional media. At low aW values (<0.2), ADH does not show any activity; at higher aW values, the activity was still lower than that in pure water due to the high viscosities of the DES. These findings could be further explained by increased enzyme flexibility with increasing water content. 相似文献
118.
Current Trends in Pretreatment and Fractionation of Lignocellulose as Reflected in Industrial Patent Activities 下载免费PDF全文
The pretreatment process to disintegrate lignocellulose and to fractionate its three main components hemicellulose, cellulose, and lignin, is a crucial step to enable sustainable and economic value chains based on biomass feedstock. This review provides an overview of the recent patenting activities on pretreatment. Most of these activities focus on optimization of different known processes to improve economics, such as increased catalyst efficiency, effluents recirculation, or lignin valorization. However, also a number of patents and demonstration activities based on emerging concepts for pretreatments are observed. 相似文献
119.
Villares R Real C Fernández JA Aboal J Carballeira A 《The Science of the total environment》2007,374(2-3):379-387
In the present study we investigated possible contamination by trace elements due to the oil slick caused by the shipwreck of the Prestige oil tanker, in two species of brown macroalgae (Fucus vesiculosus and Fucus ceranoides) collected from the coastal area most severely affected by the spill (Galicia, NW Spain). The oil slick apparently did not cause significant increases in the concentrations of the trace elements studied, except vanadium. It appears that the magnitude of terrestrial inputs to coastal waters is sufficiently high to mask the inputs of trace elements from the fuel. The observed exception of V suggests that bioaccumulation of this element by the two species of Fucus may be used to indicate exposure to petrochemical products similar to the Prestige fuel. The findings of the study are another example of the importance of the existence of Environmental Specimen Banks for studies of this type. 相似文献
120.
Sorption of Th(IV) onto two-line ferrihydrite and magnetite in NaClO4 solutions has been studied as a function of pH and ionic strength revealing that sorption onto both solids increases with pH while it is independent on ionic strength. Sorption capacity of both solids is high, the maximum sorption (almost 100% of Th(IV)) occurs at pH higher than 3.5 for ferrihydrite, and higher than 3.0 for magnetite. Sorption variation with pH was modeled with three different models using the FITEQL 4.0 code: non-electrostatic model, constant capacitance model, and diffuse-double layer model. In all cases, good fit to the experimental data is obtained with one-species: a corner-sharing bidentate-mononuclear surface complex, (FeO)2Th2+, which coincides with the surface complex postulated on these solids surface in previous spectroscopic studies; however, the monodentate species FeOThOH2+ also gives a satisfactory fit. Under the experimental conditions of the present study, any effect of possible thorium colloid formation is negligible. 相似文献