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101.
102.
Riccardo Bernardini Roberto Rinaldo Andrea Vitali Pamela Zontone 《Signal, Image and Video Processing》2011,5(1):49-60
In this paper we propose and compare different distributed video coding (DVC) schemes based on the use of the wavelet transform,
which naturally allows for spatial and other forms of scalability. In particular, we propose a hybrid encoder which utilizes
channel codes, and evaluate its performance in the absence of a feedback channel. The proposed scheme uses statistical models
for the estimation of the required bitrate at the encoder. We also propose a scheme that is based on a modulo reduction procedure
and does not use channel codes at the receiver/transmitter. These schemes are compared with more conventional coders that
do not or only partially exploit the distributed coding paradigm. Experimental results show that the considered schemes have
good performance when compared with similar asymmetric video compression schemes, and that DVC can be an interesting option
in appropriate scenarios. 相似文献
103.
Panagiota Kakni Roman Truckenmüller Pamela Habibovi Martijn van Griensven Stefan Giselbrecht 《International journal of molecular sciences》2022,23(23)
The mammalian intestinal epithelium contains more immune cells than any other tissue, and this is largely because of its constant exposure to pathogens. Macrophages are crucial for maintaining intestinal homeostasis, but they also play a central role in chronic pathologies of the digestive system. We developed a versatile microwell-based intestinal organoid-macrophage co-culture system that enables us to recapitulate features of intestinal inflammation. This microwell-based platform facilitates the controlled positioning of cells in different configurations, continuous in situ monitoring of cell interactions, and high-throughput downstream applications. Using this novel system, we compared the inflammatory response when intestinal organoids were co-cultured with macrophages versus when intestinal organoids were treated with the pro-inflammatory cytokine TNF-α. Furthermore, we demonstrated that the tissue-specific response differs according to the physical distance between the organoids and the macrophages and that the intestinal organoids show an immunomodulatory competence. Our novel microwell-based intestinal organoid model incorporating acellular and cellular components of the immune system can pave the way to unravel unknown mechanisms related to intestinal homeostasis and disorders. 相似文献
104.
Stefanie A. Khler Lisa Brandl Pamela L. Strissel Laura Gloßner Arif B. Ekici Miriam Angeloni Fulvia Ferrazzi Veronika Bahlinger Arndt Hartmann Matthias W. Beckmann Markus Eckstein Reiner Strick 《International journal of molecular sciences》2022,23(18)
Methylene blue (MB) is a dye used for histology with clinical importance and intercalates into nucleic acids. After MB staining of formalin fixed paraffin embedded (FFPE) muscle invasive bladder cancer (MIBC) and normal urothelium, specific regions could be microdissected. It is not known if MB influences RNA used for gene expression studies. Therefore, we analyzed MIBC using five different RNA isolation methods comparing patient matched FFPE and fresh frozen (FF) tissues pre-stained with or without MB. We demonstrate a positive impact of MB on RNA integrity with FF tissues using real time PCR with no interference of its chemical properties. FFPE tissues showed no improvement of RNA integrity, which we propose is due to formalin induced nucleotide crosslinks. Using direct multiplex RNA hybridization the best genes for normalization of MIBC and control tissues were identified from 34 reference genes. In addition, 5SrRNA and 5.8SrRNA were distinctive reference genes detecting <200 bp fragments important for mRNA analyses. Using these normalized RNAs from MB stained MIBC and applying multiplex RNA hybridization and mRNA sequencing, a minimal gene expression panel precisely identified luminal and basal MIBC tumor subtypes, important for diagnosis, prognosis and chemotherapy response. 相似文献
105.
Tamara T. Haque Pamela A. Frischmeyer-Guerrerio 《International journal of molecular sciences》2022,23(18)
Mast cells (MC) are a key effector cell in multiple types of immune responses, including atopic conditions. Allergic diseases have been steadily rising across the globe, creating a growing public health problem. IgE-mediated activation of MCs leads to the release of potent mediators that can have dire clinical consequences. Current therapeutic options to inhibit MC activation and degranulation are limited; thus, a better understanding of the mechanisms that regulate MC effector functions in allergic inflammation are necessary in order to develop effective treatment options with minimal side effects. Several cytokines have been identified that play multifaceted roles in regulating MC activation, including TGFβ, IL-10, and IL-33, and others that appear to serve primarily anti-inflammatory functions, including IL-35 and IL-37. Here, we review the literature examining cytokines that regulate MC-mediated allergic immune responses. 相似文献
106.
Pamela L. Nagler Russell L. Scott Craig Westenburg James R. Cleverly Edward P. Glenn Alfredo R. Huete 《Remote sensing of environment》2005,97(3):337-351
We combined remote sensing and in-situ measurements to estimate evapotranspiration (ET) from riparian vegetation over large reaches of western U.S. rivers and ET by individual plant types. ET measured from nine flux towers (eddy covariance and Bowen ratio) established in plant communities dominated by five major plant types on the Middle Rio Grande, Upper San Pedro River, and Lower Colorado River was strongly correlated with Enhanced Vegetation Index (EVI) values from the Moderate Resolution Imaging Spectrometer (MODIS) sensor on the NASA Terra satellite. The inclusion of maximum daily air temperatures (Ta) measured at the tower sites further improved this relationship. Sixteen-day composite values of EVI and Ta were combined to predict ET across species and tower sites (r2 = 0.74); the regression equation was used to scale ET for 2000-2004 over large river reaches with Ta from meteorological stations. Measured and estimated ET values for these river segments were moderate when compared to historical, and often indirect, estimates and ranged from 851-874 mm yr− 1. ET of individual plant communities ranged more widely. Cottonwood (Populus spp.) and willow (Salix spp.) stands generally had the highest annual ET rates (1100-1300 mm yr− 1), while mesquite (Prosopis velutina) (400-1100 mm yr− 1) and saltcedar (Tamarix ramosissima) (300-1300 mm yr− 1) were intermediate, and giant sacaton (Sporobolus wrightii) (500-800 mm yr− 1) and arrowweed (Pluchea sericea) (300-700 mm yr− 1) were the lowest. ET rates estimated from the flux towers and by remote sensing in this study were much lower than values estimated for riparian water budgets using crop coefficient methods for the Middle Rio Grande and Lower Colorado River. 相似文献
107.
Immune and Anticancer Responses Elicited by Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccines Modified by a TLR2 or TLR9 Agonist
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Dr. Abu‐Baker M. Abdel‐Aal Dr. Vani Lakshminarayanan Dr. Pamela Thompson Nitin Supekar Judy M. Bradley Dr. Margreet A. Wolfert Prof. Dr. Peter A. Cohen Prof. Dr. Sandra J. Gendler Prof. Dr. Geert‐Jan Boons 《Chembiochem : a European journal of chemical biology》2014,15(10):1508-1513
The mucin MUC1 is overexpressed and aberrantly glycosylated by many epithelial cancer cells manifested by truncated O‐linked saccharides. Although tumor‐associated MUC1 has generated considerable attention because of its potential for the development of a therapeutic cancer vaccine, it has been difficult to design constructs that consistently induce cytotoxic T‐lymphocytes (CTLs) and ADCC‐mediating antibodies specific for the tumor form of MUC1. We have designed, chemically synthesized, and immunologically examined vaccine candidates each composed of a glycopeptide derived from MUC1, a promiscuous Thelper peptide, and a TLR2 (Pam3CysSK4) or TLR9 (CpG‐ODN 1826) agonist. It was found that the Pam3CysSK4‐containing compound elicits more potent antigenic and cellular immune responses, resulting in a therapeutic effect in a mouse model of mammary cancer. It is thus shown, for the first time, that the nature of an inbuilt adjuvant of a tripartite vaccine can significantly impact the quality of immune responses elicited against a tumor‐associated glycopeptide. The unique adjuvant properties of Pam3CysSK4, which can reduce the suppressive function of regulatory T cells and enhance the cytotoxicity of tumor‐specific CTLs, are likely responsible for the superior properties of the vaccine candidate 1 . 相似文献
108.
Cooper M. Lynne; Frone Michael R.; Russell Marcia; Mudar Pamela 《Canadian Metallurgical Quarterly》1995,69(5):990
The present study proposed and tested a motivational model of alcohol use in which people are hypothesized to use alcohol to regulate both positive and negative emotions. Two central premises underpin this model: (a) that enhancement and coping motives for alcohol use are proximal determinants of alcohol use and abuse through which the influence of expectancies, emotions, and other individual differences are mediated and (b) that enhancement and coping motives represent phenomenologically distinct behaviors having both unique antecedents and consequences. This model was tested in 2 random samples (1 of adults, 1 of adolescents) using a combination of moderated regression and path analysis corrected for measurement error. Results revealed strong support for the hypothesized model in both samples and indicate the importance of distinguishing psychological motives for alcohol use. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
109.
D'Onofrio Brian M.; Turkheimer Eric; Emery Robert E.; Slutske Wendy S.; Heath Andrew C.; Madden Pamela A.; Martin Nicholas G. 《Canadian Metallurgical Quarterly》2005,114(4):570
Parental divorce is associated with a number of emotional and behavioral problems in young-adult offspring, but theoretical and empirical considerations suggest that the relation may be partially or fully accounted for by passive gene-environment correlation or environmental selection characteristics. The current study used the Children of Twins Design to explore whether shared environmental or genetic factors confound the relationship between parental marital instability and measures of psychopathology. Comparisons of the offspring of adult twins in Australia on 3 factors of abnormal behavior, including drug and alcohol, behavioral, and internalizing problems, suggest that environmental influences associated with divorce account for the higher rates of psychopathology. The results are consistent with a causal connection between marital instability and psychopathology in young-adult offspring. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
110.
Cunningham Sean D.; Thomas Pamela Dixon; Warschausky Seth 《Canadian Metallurgical Quarterly》2007,52(3):331
Objective: To examine gender differences in the peer relations of children with congenital neurodevelopmental conditions (NDC). Participants: Thirty-four children with cerebral palsy or spina bifida and 41 typically developing (TD) children, ages 6-12. Measures: Personality Inventory for Children-Second Edition (PIC-2), Social Network Inventory for Children-Child Version, and the Friendship Quality Questionnaire-Revised (FQQ-R). Results: Children with NDC report smaller social networks and lower quality of friendships than TD peers. Group × Gender interaction effects were not significant. Conclusion: Prior to adolescence, the social differences and risks associated with NDC do not appear to be gender specific. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献