全文获取类型
收费全文 | 3222篇 |
免费 | 196篇 |
国内免费 | 4篇 |
专业分类
电工技术 | 64篇 |
综合类 | 1篇 |
化学工业 | 858篇 |
金属工艺 | 42篇 |
机械仪表 | 72篇 |
建筑科学 | 152篇 |
矿业工程 | 1篇 |
能源动力 | 104篇 |
轻工业 | 247篇 |
水利工程 | 11篇 |
石油天然气 | 3篇 |
武器工业 | 1篇 |
无线电 | 290篇 |
一般工业技术 | 583篇 |
冶金工业 | 141篇 |
原子能技术 | 27篇 |
自动化技术 | 825篇 |
出版年
2024年 | 5篇 |
2023年 | 42篇 |
2022年 | 131篇 |
2021年 | 150篇 |
2020年 | 76篇 |
2019年 | 90篇 |
2018年 | 100篇 |
2017年 | 92篇 |
2016年 | 144篇 |
2015年 | 115篇 |
2014年 | 147篇 |
2013年 | 220篇 |
2012年 | 202篇 |
2011年 | 233篇 |
2010年 | 193篇 |
2009年 | 192篇 |
2008年 | 180篇 |
2007年 | 169篇 |
2006年 | 119篇 |
2005年 | 94篇 |
2004年 | 118篇 |
2003年 | 96篇 |
2002年 | 63篇 |
2001年 | 51篇 |
2000年 | 43篇 |
1999年 | 39篇 |
1998年 | 28篇 |
1997年 | 29篇 |
1996年 | 35篇 |
1995年 | 28篇 |
1994年 | 26篇 |
1993年 | 20篇 |
1992年 | 19篇 |
1991年 | 10篇 |
1990年 | 6篇 |
1989年 | 11篇 |
1988年 | 2篇 |
1987年 | 12篇 |
1986年 | 5篇 |
1985年 | 16篇 |
1984年 | 17篇 |
1983年 | 9篇 |
1982年 | 7篇 |
1981年 | 7篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1975年 | 3篇 |
1973年 | 3篇 |
排序方式: 共有3422条查询结果,搜索用时 0 毫秒
91.
Corrigendum: Discovery of a Potent BTK Inhibitor with a Novel Binding Mode by Using Parallel Selections with a DNAEncoded Chemical Library 下载免费PDF全文
92.
In this paper, data are reported for the behaviour of some charcoals during combustion and devolatilization in a thermal analyser. 相似文献
93.
Michele Iuliani Sonia Simonetti Giulia Ribelli Andrea Napolitano Umile Giuseppe Longo Bruno Vincenzi Paolo Orsaria Vincenzo Denaro Giuseppe Tonini Daniele Santini Pantano Francesco 《International journal of molecular sciences》2022,23(5)
The CDK4/6 inhibitors (CDKi) palbociclib, ribociclib, and abemaciclib are currently approved in combination with anti-estrogen therapy for the treatment of advanced and/or metastatic hormone receptor-positive/HER2-neu-negative breast cancer patients. Given the high incidence of bone metastases in this population, we investigated and compared the potential effects of palbociclib, ribociclib, and abemaciclib on the breast cancer bone microenvironment. Primary osteoclasts (OCs) and osteoblasts (OBs) were obtained from human monocyte and mesenchymal stem cells, respectively. OC function was evaluated by tartrate-resistant acid phosphatase assay and real-time PCR; OB activity was assessed by an alizarin red assay. OB/breast cancer co-culture models were generated via the seeding of MCF-7 cells on a layer of OBs, and tumor cell proliferation was analyzed using flow cytometry. Here, we showed that ribociclib, palbociclib, and abemaciclib exerted similar inhibitory effects on the OC differentiation and expression of bone resorption markers without affecting OC viability. On the other hand, the three CDKi did not affect the ability of OB to produce bone matrix, even if the higher doses of palbociclib and abemaciclib reduced the OB viability. In OB/MCF-7 co-culture models, palbociclib demonstrated a lower anti-tumor effect than ribociclib and abemaciclib. Overall, our results revealed the direct effects of CDKi on the tumor bone microenvironment, highlighting differences potentially relevant for clinical practice. 相似文献
94.
Karthik Sathiyanadan Florian Alonso Sonia Domingos-Pereira Tania Santoro Lauriane Hamard Valrie Cesson Paolo Meda Denise Nardelli-Haefliger Jacques-Antoine Haefliger 《International journal of molecular sciences》2022,23(6)
Connexin37 (Cx37) and Cx40 form intercellular channels between endothelial cells (EC), which contribute to the regulation of the functions of vessels. We previously documented the participation of both Cx in developmental angiogenesis and have further shown that loss of Cx40 decreases the growth of different tumors. Here, we report that loss of Cx37 reduces (1) the in vitro proliferation of primary human EC; (2) the vascularization of subcutaneously implanted matrigel plugs in Cx37−/− mice or in WT using matrigel plugs supplemented with a peptide targeting Cx37 channels; (3) tumor angiogenesis; and (4) the growth of TC-1 and B16 tumors, resulting in a longer mice survival. We further document that Cx37 and Cx40 function in a collaborative manner to promote tumor growth, inasmuch as the injection of a peptide targeting Cx40 into Cx37−/− mice decreased the growth of TC-1 tumors to a larger extent than after loss of Cx37. This loss did not alter vessel perfusion, mural cells coverage and tumor hypoxia compared to tumors grown in WT mice. The data show that Cx37 is relevant for the control of EC proliferation and growth in different tumor models, suggesting that it may be a target, alone or in combination with Cx40, in the development of anti-tumoral treatments. 相似文献
95.
Francesco Borgia Lucia Peterle Paolo Custurone Mario Vaccaro Giovanni Pioggia Sebastiano Gangemi 《International journal of molecular sciences》2022,23(6)
Acne Vulgaris (AV) and Hidradenitis suppurativa (HS) are common chronic inflammatory skin conditions that affect the follicular units that often coexist or are involved in differential diagnoses. Inflammation in both these diseases may result from shared pathways, which may partially explain their frequent coexistence. MicroRNAs (miRNAs) are a class of endogenous, short, non-protein coding, gene-silencing or promoting RNAs that may promote various inflammatory diseases. This narrative review investigates the current knowledge regarding miRNAs and their link to AV and HS. The aim is to examine the role of these molecules in the pathogenesis of AV and HS and to identify possible common miRNAs that could explain the similar characteristics of these two diseases. Five miRNA (miR-155 miR-223-, miR-21, and miRNA-146a) levels were found to be altered in both HS and AV. These miRNAs are related to pathogenetic aspects common to both pathologies, such as the regulation of the innate immune response, regulation of the Th1/Th17 axis, and fibrosis processes that induce scar formation. This review provides a starting point for further studies aimed at investigating the role of miRNAs in AV and HS for their possible use as diagnostic-therapeutic targets. 相似文献
96.
Claudia Malerba Francesco Biccari Cristy Leonor Azanza RicardoMirco D’Incau Paolo ScardiAlberto Mittiga 《Solar Energy Materials & Solar Cells》2011,95(10):2848-2854
The optical absorption coefficient of thin film and bulk Cu2O at room temperature is obtained from an accurate analysis of their transmittance and reflectance spectra. These absorption spectra are modeled, together with the low temperature data reported in the literature, using an analytical expression to assess and quantify the role of the different absorption mechanisms. The results suggest that direct forbidden transitions and indirect transitions play an almost equally relevant role. A table of the optical constants of Cu2O single crystal is given for reference. 相似文献
97.
In the perspective of reducing land occupation of built environments, the most efficient strategy is to increase the reuse of obsolete or abandoned constructions instead of designing new buildings. This is particularly true regarding public buildings, usually characterized by considerable dimensions. The paper is focused on this issue, particularly on its energy implications. It analyzes the headquarters of the “G. D’Annunzio” University in Pescara, Italy, initially designed for commercial use and later converted to a university building during its construction. The authors first carried out a numerical analysis of the building energy performance in its current state and then they proposed some improvement interventions evaluating their incidence on the annual energy balance of the building, showing how the most commonly used energy saving strategies do not give the best results in any case, being greatly influenced by the climatic zone in which the building is located. Starting from these considerations, the authors carried out the analysis by considering three different Italian climatic conditions so as to determine their influence on the building energy performance and to define the best strategy for energy requalification in each climatic zone. 相似文献
98.
Alberto Casagrande Joanna Jarmolowska Marcello Maria Turconi Pierpaolo Busan Piero Paolo Battaglini 《International journal of human-computer interaction》2018,34(12):1085-1104
One application of the P300 brain electric signal is sentence spelling, which enables subjects who have lost control of their motor pathways to communicate by selecting characters in a matrix containing all alphabet symbols. This technology still suffers from both low communication/high error rates. A P300 speller, named PolyMorph, which jointly introduces the selection matrix polymorphism (reducing the matrix size by removing useless symbols) and sentence-based predictions (which forecast words on the basis of language statistics) is presented. This is accomplished by using a custom dynamic knowledge-base, tailored to the subject lexicon, and updated in real time with the selections of the subject. The effectiveness of the presented speller is measured in vivo and in silico. The results suggest that the use of PolyMorph increases the number of spelt characters per time unit and reduces the error rate. 相似文献
99.
Paolo Bonavoglia 《Cryptologia》2018,42(3):205-221
Letters, notes, and above all an original notebook by Luigi Sacco dated 1916 have shed new light on the establishment and development of the “Ufficio (or Reparto) Crittografico” of the Italian Army Headquarters in World War I. Three decrypted messages, unpublished until now, are included with Sacco’s comments. 相似文献
100.