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排序方式: 共有600条查询结果,搜索用时 10 毫秒
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Laurent Bédouet Florentina Pascale Michel Bonneau Alexandre Laurent 《Drug development and industrial pharmacy》2015,41(1):85-94
Intra-articular drug delivery systems (DDSs) are envisaged as interesting alternative to locally release non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen to reduce pain in patients with osteoarthritis. The present study examines the efficacy of S-(+)-ibuprofen on cartilage degradation as drug candidate for DDS loading. Humeral cartilage and joint capsule explants were collected from healthy sheep shoulder joints and they were cultured in mono- or in co-culture for 13?days with LPS in combination with S-(+)-ibuprofen at 50?µM and 1?mM. S-(+)-ibuprofen (50?µM) blocked prostaglandins production in LPS-activated explants but did not reduce cartilage degradation. By contrast, 1?mM S-(+)-ibuprofen treatment of cartilage explants reduced nitric oxide synthesis by 51% (p?=?0.0072), proteoglycans degradation by 35% (p?=?0.0114) and expression of serum amyloid protein – the main protein induced upon LPS challenge – by 44% (p?0.0001). On contrary, in presence of synovial membrane, the protective effects of S-(+)-ibuprofen on cartilage damages were significantly diminished. At 1mM, S-(+)-ibuprofen reduced the cell lysis during culture of cartilage and joint capsule either in mono- or in co-culture. This study performed on sheep explants shows that 1?mM S-(+)-ibuprofen inhibited cartilage degradation via a mechanism independent of cyclooxygenase inhibition. Reduction of prostaglandins synthesis at 50?µM in all treatment groups and reduction of cartilage degradation observed at 1?mM suggest that S-(+)-ibuprofen could be considered as a promising drug candidate for the loading of intra-articular DDS. 相似文献
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Rapid computation of the QR factorization of a matrix is fundamental to many scientific and engineering problems. The paper presents a family of algorithms parameterized by the number of processors available P, arithmetic grain aggregation parameters g1, g2, …, gP, and communication grain aggregation parameter h, which computer the QR factorization of a matrix A ∈ Cm × n with minimal latency. The approach is particularly well suited for dedicated distributed memory architectures such as linear arrays of INMOS Transputers, Texas Instruments C40s or Analog Devices 21060s. 相似文献
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Mazel V Richardin P Debois D Touboul D Cotte M Brunelle A Walter P Laprévote O 《Analytical chemistry》2007,79(24):9253-9260
A new protocol is implemented to demonstrate the presence of blood in the patina of African art objects from Mali. Divided into three steps, the protocol first consists in demonstrating the presence of proteins and localizing them in the sample's cross sections using time-of-flight secondary ion mass spectrometry (TOF-SIMS) and synchrotron-based infrared microspectrometry (microFT-IR). In a second time, TOF-SIMS is used to investigate heme, which is a blood marker. If heme is missing, which could mean that it is too degraded to be detected, X-ray microfluorescence (microXRF) and X-ray absorption near-edge microspectroscopy (microXANES) are used to prove the presence of iron in the protein area and to get a fingerprint of its chemical environment. This permits us thus to demonstrate that iron is indeed linked with proteins and not with mineral phases of the sample. Coupled with the ritual context of the objects, this constitutes a proof of the use of blood. Thanks to this protocol, which has the major advantage of avoiding false positive results, the presence of blood has been demonstrated in seven out of the eight studied samples. 相似文献
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Isabelle L. Di Ma?o Pascale Barbier Diane Allegro Cédric Brault Vincent Peyrot 《International journal of molecular sciences》2014,15(8):14697-14714
The interaction between the microtubule associated protein, tau and the microtubules is investigated. A fluorescence resonance energy transfer (FRET) assay was used to determine the distance separating tau to the microtubule wall, as well as the binding parameters of the interaction. By using microtubules stabilized with Flutax-2 as donor and tau labeled with rhodamine as acceptor, a donor-to-acceptor distance of 54 ± 1 Å was found. A molecular model is proposed in which Flutax-2 is directly accessible to tau-rhodamine molecules for energy transfer. By titration, we calculated the stoichiometric dissociation constant to be equal to 1.0 ± 0.5 µM. The influence of the C-terminal tails of αβ-tubulin on the tau-microtubule interaction is presented once a procedure to form homogeneous solution of cleaved tubulin has been determined. The results indicate that the C-terminal tails of α- and β-tubulin by electrostatic effects and of recruitment seem to be involved in the binding mechanism of tau. 相似文献
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Vertically aligned carbon nanotube‐based composite: Elaboration and monitoring of the nanotubes alignment 下载免费PDF全文
Mickael Huard Florent Roussel Stéphan Rouzière Stéphanie Patel Mathieu Pinault Martine Mayne‐L'Hermite Pascale Launois 《应用聚合物科学杂志》2014,131(1)
We present the different elaboration steps of a composite formed of carbon nanotubes (CNT) carpet embedded in an epoxy polymer. Detailed characterization at each step of the elaboration process is performed. The good alignment of CNT in as‐grown carpets is kept all along the elaboration process of the composite, as it is measured at both macro and microscopic scales by X‐ray scattering. We also ensured by X‐ray fluorescence measurements that the iron‐based catalyst particles used for the synthesis were removed from the carpet after a high temperature post‐annealing treatment. These measurements give valuable information for further applications involving unidirectional nanotube composites and membranes, where CNT alignment is a key parameter. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 39730. 相似文献
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Pascale Satgé de Caro Zéphirin Mouloungui Antoine Gaset 《Journal of the American Oil Chemists' Society》1997,74(3):235-240
Alkyl glycidyl ethers and bis glycidyl ethers, synthesized in a heterogeneous weakly hydrous medium, were condensed with primary
or secondary amines to obtain 3-alkyloxy propanolamines or bis alkyloxy propanolamines in a regioselective manner. The compounds
were characterized by conventional spectroscopic methods, and complete nuclear magnetic resonance data are given. Their high-temperature
stability, their good emulsifying power, their oxidation, and corrosion inhibition make these compounds suitable for solubilizing
ethanol-diesel fuel blends. 相似文献