Hot embossing of diffractive optically variable images in biaxially-oriented polypropylene

The hot embossing of grating-based optically variable devices has been demonstrated in biaxially-oriented polypropylene (BOPP). Embossing of the grating structures was examined over a range of temperatures (80-155 °C) at 135 kN force. However, only at temperatures above the glass transition temperature, T_g, was high quality replication achieved over a full embossing area of 80 × 80 mm. The embossing of several different types of optically variable device has been examined including portrait, non-portrait and 3-dimensional images. The images embossed into BOPP have displayed an optically variable effect when viewed in transmitted light.     

Comparing the streaming of FGS encoded video at different aggregation levels: frame,GoP, and scene

Fine granularity scalability (FGS), a new coding technique that has recently been added to the MPEG‐4 video coding standard, allows for the flexible scaling of each individual video frame at very fine granularity. This flexibility makes FGS video very well suited for rate‐distortion optimized streaming mechanisms, which minimize the distortion (i.e. maximize the quality) of the streamed video by transmitting the optimal number of bits for each individual frame. The per‐frame optimization of the transmission schedule, however, puts a significant computational burden on video servers and intermediate streaming gateways. In this paper we investigate the rate‐distortion optimized streaming at different video frame aggregation levels. We find that compared to the optimization for each individual video frame, optimization at the level of video scenes reduces the computational effort dramatically, while reducing the video quality only very slightly. Copyright © 2005 John Wiley & Sons, Ltd.     

Stable single-frequency fiber ring laser for 25-GHz ITU-T grids utilizing saturable absorber filter

A stable single-frequency fiber ring laser is proposed that operates in a single mode for more than an hour by incorporating unpumped erbium-doped fiber (EDF) as a saturable absorber filter and optimizing the length of EDF used as gain medium. This laser can be continuously tuned to 25-GHz spacing that precisely matches the ITU-T grids by temperature control of etalon filter. This laser had a signal-to-source spontaneous emission ratio higher than 70 dB, and lasing frequencies of 361 channels was matched to ITU-T grids with excellent flatness. Frequency offset from the ITU-T grid was less than 0.14 GHz. The linewidth and the relative intensity noise value was less than 1.3 kHz and 130 dB/Hz (above 250 kHz), respectively.     

Accuracy of carotid strain estimates from ultrasonic wall tracking: a study based on multiphysics simulations and in vivo data

We used a multiphysics model to assess the accuracy of carotid strain estimates derived from a 1-D ultrasonic wall tracking algorithm. The presented tool integrates fluid-structure interaction (FSI) simulations with an ultrasound simulator (Field II), which allows comparison of the ultrasound (US) images with a ground truth. Field II represents tissue as random points on which US waves reflect and whose position can be updated based on the flow field and vessel wall deformation from FSI. We simulated the RF-signal of a patient-specific carotid bifurcation, including the blood pool as well as the vessel wall and surrounding tissue. Distension estimates were obtained from a wall tracking algorithm using tracking points at various depths within the wall, and further processed to assess radial and circumferential strain. The simulated data demonstrated that circumferential strain can be estimated with reasonable accuracy (especially for the common carotid artery and at the lumen-intima and media-adventitia interface), but the technique does not allow to reliably assess intra-arterial radial strain. These findings were supported by in vivo data of 10 healthy adults, showing similar circumferential and radial strain profiles throughout the arterial wall. We concluded that these deviations are present due to the complex 3-D vessel wall deformation, the presence of specular reflections and, to a lesser extent, the spatially varying beam profile, with the error depending on the phase in the cardiac cycle and the scanning location.     

A comparison between high-pass and low-pass \Updelta\Upsigma modulators

In this paper, high-pass (HP) $\Updelta\Upsigma$ modulators are compared against the traditional low-pass (LP) $\Updelta\Upsigma$ modulators. The objective of this comparison is to point out the advantages and drawbacks of the two modulators thereby allowing choosing the most suited for a given application. The metrics of comparison are the noise floor, power consumption, area and the effect of the non-idealities of all the basic blocks (i.e., operational transconductance amplifier, quantizer, switches and clocks). The comparative analysis shows that HP modulators are more suited for narrow band applications because of their immunity against DC-offset and flicker noise. For medium and wide band applications, LP modulators are preferred because of their higher robustness against switch imperfections and clock jitter.     

Design of Low-Voltage Highly Linear Switched-R-MOSFET-C Filters

This paper discusses the design, analysis and performance of a low-voltage, highly linear switched-R-MOSFET-C filter. High linearity, even at a low supply voltage, is achieved through the use of duty-cycle-controlled tuning. Tuning MOSFETs are switched completely on while conducting, such that their nonlinear resistance is much smaller than the linear filter resistors, resulting in low distortion. The MOSFETs are also placed inside the filter feedback loop which further reduces distortion. Because tuning is done in the time domain, rather than in the voltage domain, the tuning range is independent of the supply voltage. The filter achieves -77 dB total harmonic distortion (THD) using a 0.6-V supply, and -90 dB THD using a 0.8-V supply, with a 0.6-Vpp differential 2 kHz sine input. The prototype IC, implemented in a 0.18-mum CMOS process, occupies an area of 0.7 mm² and consumes 1 mW of power from a 0.6-V supply.     

Noise reduction in rhythmic and multitrial biosignals with applications to event-related potentials

A new noise reduction algorithm is presented for signals displaying repeated patterns or multiple trials. Each pattern is stored in a matrix, forming a set of events, which is termed multievent signal. Each event is considered as an affine transform of a basic template signal that allows for time scaling and shifting. Wavelet transforms, decimated and undecimated, are applied to each event. Noise reduction on the set of coefficients of the transformed events is applied using either wavelet de- noising or principal component analysis (PCA) noise reduction methodologies. The method does not require any manual selection of coefficients. Nonstationary multievent synthetic signals are employed to demonstrate the performance of the method using normalized mean square error against classical wavelet and PCA based algorithms. The new method shows a significant improvement in low SNRs (typically <0 dB). On the experimental side, evoked potentials in a visual oddball paradigm are used. The reduced-noise visual oddball event-related potentials reveal gradual changes in morphology from trial to trial (especially for N1-P2 and N2-P3 waves at Fz), which can be hypothetically linked to attention or decision processes. The new noise reduction method is, thus, shown to be particularly suited for recovering single-event features in non- stationary low SNR multievent contexts.     

Capillary Network‐Like Organization of Endothelial Cells in PEGDA Scaffolds Encoded with Angiogenic Signals via Triple Helical Hybridization

Survival of tissue engineered constructs after implantation depends on proper vascularization. The differentiation of endothelial cells into mature microvasculature requires dynamic interactions between cells, scaffold, and growth factors, which are difficult to recapitulate in artificial systems. Previously, photocrosslinked poly(ethylene glycol) diacrylate (PEGDA) hydrogels displaying collagen mimetic peptides (CMPs), dubbed PEGDA‐CMP, that can be further conjugated with bioactive molecules via CMP‐CMP triple helix hybridization were reported. Here, it is shown that a bifunctional peptide featuring pro‐angiogenic domain mimicking vascular endothelial growth factor (VEGF) and a collagen mimetic domain that can fold into a triple helix conformation can hybridize with CMP side chains of the PEGDA‐CMP hydrogel, which results in presentation of insoluble VEGF‐like signals to endothelial cells. Presentation of VEGF‐like signals on the surface of micropatterned scaffolds in this way transforms cells from a quiescent state to elongated and aligned phenotype suggesting that this system could be used to engineer organized microvasculature. It is also shown that the pro‐angiogenic peptide, when applied topically in combination with modified dextran/PEGDA hydrogels, can enhance neovascularization of burn wounds in mice demonstrating the potential clinical use of CMP‐mediated matrix‐bound bioactive molecules for dermal injuries.     

Inductively heated shape memory polymer for the magnetic actuation of medical devices

Presently, there is interest in making medical devices such as expandable stents and intravascular microactuators from shape memory polymer (SMP). One of the key challenges in realizing SMP medical devices is the implementation of a safe and effective method of thermally actuating various device geometries in vivo. A novel scheme of actuation by Curie-thermoregulated inductive heating is presented. Prototype medical devices made from SMP loaded with nickel zinc ferrite ferromagnetic particles were actuated in air by applying an alternating magnetic field to induce heating. Dynamic mechanical thermal analysis was performed on both the particle-loaded and neat SMP materials to assess the impact of the ferrite particles on the mechanical properties of the samples. Calorimetry was used to quantify the rate of heat generation as a function of particle size and volumetric loading of ferrite particles in the SMP. These tests demonstrated the feasibility of SMP actuation by inductive heating. Rapid and uniform heating was achieved in complex device geometries and particle loading up to 10% volume content did not interfere with the shape recovery of the SMP.     

Real-Time 3-D Sensing, Visualization and Recognition of Dynamic Biological Microorganisms

We introduce optical imaging techniques for three-dimensional (3-D)visualization and identification of microorganisms. Three-dimensional sensing and reconstruction is performed by single-exposure on-line (SEOL)digital holography. A coherent microscope-based Mach-Zehnder interferometer records Fresnel digital holograms of microorganisms. Complex amplitude holographic images are computationally reconstructed at different depths by an inverse Fresnel transformation. For pattern recognition/identification, two approaches are addressed. One is 3-D morphology-based recognition and the other is shape-tolerant 3-D recognition. In the first approach, a series of image recognition techniques is used to analyze 3-D geometrical shapes of microorganisms, which is composed of magnitude and phase distributions. Segmentation, feature extraction, graph matching, feature selection, training, and decision rules are presented. For the second approach, a number of sampling segments are arbitrarily extracted from the reconstructed 3-D biological microorganism. These samples are processed using a number of cost functions and statistical inference theory for the equality of means and equality of variances between the sampling segments. Experimental results with sphacelaria alga, tribonema aequale alga, and polysiphonia alga are presented.