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41.
Patrycja Bober Jaroslav Stejskal Miroslava Trchová Jiřina Hromádková Jan Prokeš 《Reactive and Functional Polymers》2010,70(9):656-662
Two non-conducting chemicals, aniline and silver nitrate, dissolved in formic acid solutions, yielded a composite of two conducting products, polyaniline and silver. As the concentration of formic acid increased, an alternative reaction, the reduction of silver nitrate with formic acid to silver became dominant, and the content of silver in the composites increased. The formation of polyaniline was confirmed by UV–visible, FTIR, and Raman spectroscopies. The typical conductivity of composites was 43 S cm?1 at 84 wt.% of silver. Silver nanowires coated with polyaniline nanobrushes are produced at low concentrations of formic acid, the granular silver particles covered with polyaniline dominate at high acid concentrations. 相似文献
42.
Joanna Pilch Patrycja Kowalik Agata Kowalczyk Piotr Bujak Artur Kasprzak Ewa Paluszkiewicz Ewa Augustin Anna M. Nowicka 《International journal of molecular sciences》2022,23(3)
Targeted drug delivery by nanocarriers molecules can increase the efficiency of cancer treatment. One of the targeting ligands is folic acid (FA), which has a high affinity for the folic acid receptors, which are overexpressed in many cancers. Herein, we describe the preparation of the nanoconjugates containing quantum dots (QDs) and β-cyclodextrin (β-CD) with foliate-targeting properties for the delivery of anticancer compound C-2028. C-2028 was bound to the nanoconjugate via an inclusion complex with β-CD. The effect of using FA in QDs-β-CD(C-2028)-FA nanoconjugates on cytotoxicity, cellular uptake, and the mechanism of internalization in cancer (H460, Du-145, and LNCaP) and normal (MRC-5 and PNT1A) cells was investigated. The QDs-β-CD(C-2028)-FA were characterized using DLS (dynamic light scattering), ZP (zeta potential), quartz crystal microbalance with dissipation (QCM-D), and UV-vis spectroscopy. The conjugation of C-2028 with non-toxic QDs or QDs-β-CD-FA did not change the cytotoxicity of this compound. Confocal microscopy studies proved that the use of FA in nanoconjugates significantly increased the amount of delivered compound, especially to cancer cells. QDgreen-β-CD(C-2028)-FA enters the cells through multiple endocytosis pathways in different levels, depending on the cell line. To conclude, the use of FA is a good self-navigating molecule in the QDs platform for drug delivery to cancer cells. 相似文献
43.
Anna Janik Urszula Perliska-Lenart Katarzyna Gawarecka Justyna Augustyniak Ewelina Bratek-Gerej Przemysaw Bernat Sebastian Pisyk Patrycja Skalmowska Grayna Palamarczyk Ewa Swiezewska Joanna S. Kruszewska 《International journal of molecular sciences》2022,23(1)
Protein glycosylation requires dolichyl phosphate as a carbohydrate carrier. Dolichols are α-saturated polyprenols, and their saturation in S. cerevisiae is catalyzed by polyprenyl reductase Dfg10 together with some other unknown enzymes. The aim of this study was to identify such enzymes in Candida. The Dfg10 polyprenyl reductase from S. cerevisiae comprises a C-terminal 3-oxo-5-alpha-steroid 4-dehydrogenase domain. Alignment analysis revealed such a domain in two ORFs (orf19.209 and orf19.3293) from C. albicans, which were similar, respectively, to Dfg10 polyprenyl reductase and Tsc13 enoyl-transferase from S. cerevisiae. Deletion of orf19.209 in Candida impaired saturation of polyprenols. The Tsc13 homologue turned out not to be capable of saturating polyprenols, but limiting its expression reduce the cellular level of dolichols and polyprenols. This reduction was not due to a decreased expression of genes encoding cis-prenyltransferases from the dolichol branch but to a lower expression of genes encoding enzymes of the early stages of the mevalonate pathway. Despite the resulting lower consumption of acetyl-CoA, the sole precursor of the mevalonate pathway, it was not redirected towards fatty acid synthesis or elongation. Lowering the expression of TSC13 decreased the expression of the ACC1 gene encoding acetyl-CoA carboxylase, the key regulatory enzyme of fatty acid synthesis and elongation. 相似文献
44.
45.
In this study the effect of an anionic surfactant (sodium dodecyl sulfate SDS) and oils (hydrocarbons: C12–C16) on the formation
and phase behavior of the systems of oil/monoacylglycerols (MAG):SDS/propylene glycol/water has been investigated. The effects
of the surfactant mixture on the phase behavior and the concentration of water or oil in the systems were studied at three
temperatures (50, 55, 60 °C). Electrical conductivity measurement, FT-IR spectroscopy and differential scanning calorimetry
methods were applied to determine the structure and type of the microemulsions formed. The dimension of microemulsion droplets
was characterized by dynamic light scattering. It has been stated that the concentration of SDS has a strong influence on
the shape and extent of the microemulsion areas. Addition of an ionic surfactant to the mixture with MAG promotes an increase
in the area of microemulsion formation in the phase diagrams, and these areas of the isotropic region change with the temperature.
It was shown that the presence in the systems of a surfactant more hydrophilic than MAG caused an increase in water content
in the microemulsions. It was found that, depending on temperature and concentration of the surfactant mixture, it was possible
to obtain a W/O type microemulsion with a dispersed particles size distribution ranging from 20 to 50 nm and containing about
17–38% water in the system. Among different alkanes (from C12 to C16), hexadecane embedded microemulsions showed a maximum
water solubilization capacity. 相似文献
46.
Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology
47.
P. Luches S. Benedetti L. Pasquini F. Boscherini M. Zając J. Korecki R. Rüffer S. Valeri 《Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms》2010,268(3-4):361-364
We used nuclear hyperfine spectroscopies and a 57Fe probe layer approach to study the depth-dependent magnetic properties of ultrathin Fe films on NiO(0 0 1), a system exhibiting exchange bias. Conversion electron Mössbauer spectroscopy and nuclear resonance scattering of synchrotron radiation were employed. The samples were two Fe films with a thickness (8–10 ML) slightly above the critical thickness for the onset of ferromagnetism at room temperature, in which a 2 ML-thick probe layer, enriched in the 57Fe Mössbauer isotope, was embedded at different depths from the Fe/NiO interface. Both techniques indicate that inside the film Fe has a metallic character, while at the interface with NiO different Fe phases are present. The main conclusion is that already a few monolayers from the interface with NiO the magnetic properties of Fe are bulk-like. 相似文献
48.
The aim of the present article was an attempt to compare the influence of the presence of a diesel particulate filter (DPF) on the content of contaminants (Fe, Cr, Ni, Pb) and the level of changes of physical and chemical parameters (such as kinematic viscosity, TBN, TAN) in engine oils during their service life. The article presents changes occurring in engine oils at various stages of use. Medium infrared Eralitics ERASPEC OIL FT-IR spectrometer and XOS HDMaxine (powered by High Definition X-ray Fluorescence) were used. Based on the conducted experiment, statistically significant differences in diesel fuel content were noticed. 相似文献
49.
Inflammatory bowel disease (IBD) is one of the leading gut chronic inflammation disorders, especially prevalent in Western countries. Recent research suggests that mitochondria play a crucial role in IBD development and progression to the more severe disease—colorectal cancer (CRC). In this review, we focus on the role of mitochondrial mutations and dysfunctions in IBD and CRC. In addition, main mitochondria-related molecular pathways involved in IBD to CRC transition are discussed. Additionally, recent publications dedicated to mitochondria-targeted therapeutic approaches to cure IBD and prevent CRC progression are discussed. 相似文献
50.
Daria Podstawczyk Martyna Nizioł Patrycja Szymczyk-Ziółkowska Marta Fiedot-Toboła 《Advanced functional materials》2021,31(15):2009664
4D printing has emerged as an important technique for fabricating 3D objects from programmable materials capable of time-dependent reshaping. In the present investigation, novel 4D thermoinks composed of laponite (LAP), an interpenetrating network of poly(N-isopropylacrylamide) (PNIPAAm), and alginate (ALG) are developed for direct printing of shape-morphing structures. This approach consists of the design and fabrication of 3D honeycomb-patterned hydrogel discs self-rolling into tubular constructs under the stimulus of temperature. The shape morphing behavior of hydrogels is due to shear-induced anisotropy generated via 3D printing. The compositionally tunable hydrogel discs can be programmed to exhibit different actuation behaviors at different temperatures. Upon immersion in 12 °C water, singly crosslinked sheets roll up into a tubular construct. When transferred to 42 °C water, the tubes first rapidly unfold and then slightly curve up in the opposite direction. Through a dual photocrosslinking of PNIPAAm, it is possible to inverse temperature-dependent shape morphing and induce self-folding at higher and unrolling at lower temperatures. The extensive self-assembling motion is essential to developing thermal actuators with broad applications in, e.g., soft robotics and active implantology, whereas controllable self-rolling of planar hydrogels is of the highest interest to biomedical engineering as it allows for effective fabrication of hollow tubes. 相似文献