Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the Chemoprevention of Colorectal Cancer

Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. Although conclusive evidence is still lacking, epidemiologic studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) has chemopreventive properties against CRC. Similarly, regular consumption of mesalazine, a drug structurally related to NSAIDs, seems to reduce the risk of CRC in patients with ulcerative colitis. These observations are supported by a large body of experimental data showing the ability of such drugs to inhibit multiple pathways that sustain colon carcinogenesis. This review summarizes the current information on the molecular mechanisms by which NSAIDs and mesalazine could interfere with CRC cell growth and survival.     

A comparison of two new take-away strategies and their relation to rating and ranking of extrinsic properties of dry cured ham

This paper is a study of the relationship between rating, ranking and take-away choices of dry cured ham. Extrinsic attributes related to country of origin, ageing time and price are considered and we study average population results as well as individual differences. Two tests with different sample size and different take-away strategies are explored. The results show that the ranking and rating data provide similar information in both tests. From an average point of view the stated results have also similarities with the take-away results, but with some notable differences. Relatively large individual differences in ranking of the products were observed in the two tests. Another finding in this study is that information about type of meal has a strong effect on the ranks of the products for all responses.     

Small stationary reformers for H2 production from hydrocarbons

This paper describes the activities performed in ENEA (Italian National Agency for New Technologies, Energy and Environment) during the last years in order to investigate the hydrogen production from largely available hydrocarbons, such as natural gas [1] and LPG (Liquefied Petroleum Gas), aimed at feeding Polymer Electrolyte Fuel Cells (PEFC) in the 1–5 kW electric power range.     

Multisensor data fusion for physical activity assessment

This paper presents a sensor fusion method for assessing physical activity (PA) of human subjects, based on support vector machines (SVMs). Specifically, acceleration and ventilation measured by a wearable multisensor device on 50 test subjects performing 13 types of activities of varying intensities are analyzed, from which activity type and energy expenditure are derived. The results show that the method correctly recognized the 13 activity types 88.1% of the time, which is 12.3% higher than using a hip accelerometer alone. Also, the method predicted energy expenditure with a root mean square error of 0.42 METs, 22.2% lower than using a hip accelerometer alone. Furthermore, the fusion method was effective in reducing the subject-to-subject variability (standard deviation of recognition accuracies across subjects) in activity recognition, especially when data from the ventilation sensor were added to the fusion model. These results demonstrate that the multisensor fusion technique presented is more effective in identifying activity type and energy expenditure than the traditional accelerometer-alone-based methods.     

Effect of acute corticotropin releasing factor on pituitary-adrenocortical responsiveness in elderly women and men

Aging is related to critical changes of the hypothalamo-pituitary-adrenal function. A decline in serum DHEA levels has been demonstrated in healthy elderly subjects, while ACTH and cortisol concentrations remain at normal values. The purpose of the present study was to investigate the effect of aging on pituitary-adrenal responsiveness to hCRF in subjects of both sexes. A group of 12 physically and mentally healthy elderly subjects and a group of 12 young controls of both sexes have been selected. Blood samples were collected before and after i.v. bolus injection of hCRF; ACTH, cortisol and DHEA levels were then determined by RIA. Basal ACTH and cortisol levels did not result statistically different between controls and elderly subjects, while DHEA showed a clear and significant age-related decrease (p < 0.01). Following the hCRF injection, the responses of ACTH, cortisol and DHEA in aged subjects were higher than in young controls; ACTH (p < 0.03) and cortisol (p < 0.01) were higher in aged women than in men. The present study demonstrated that aging is associated with an increased responsiveness of ACTH, cortisol and DHEA to exogenous hCRF supply. A hyperactivation of the pituitary-adrenal secretory activity may explain the age-related of the same axis. Gender probably has a significant influence on basal and stimulated hormonal secretion. In conclusion, hCRF test may become a useful clinical tool in establishing a neuroendocrine correlation with central disturbances associated to aging.     

Mechanically interlocked gold and silver nanoparticles using metallosupramolecular catenane chemistry

We have employed the toolbox of metallosupramolecular chemistry to mechanically interlock gold and silver nanoparticles. A specifically designed PEGthiol-functionalized bis(phenanthroline)copper(I) complex acts to 'catenate' the nanoparticles. The interlocked assemblies were characterised by three complementary techniques: DLS, SERS and TEM.