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排序方式: 共有1691条查询结果,搜索用时 15 毫秒
991.
Pavel Propastin 《Lakes & Reservoirs: Research and Management》2012,17(3):161-169
The variation in Lake Balkhash water levels during the period from 1992 to 2010 and their relationship with climate dynamics were investigated in this study, using satellite altimetry data and meteorological records from climate stations located in the lake catchment basin. The altimetry‐derived water level demonstrated a general water level increase, reaching a mean value of 8.1 cm year?1 in July 2005, with a maximum value of 342.52 m. The increased Lake Balkhash water level was accompanied by an overall upward trend in precipitation and temperature in the catchment basin during the study period. A strong increase in the winter and spring temperature was the main contributor to the general upward temperature trend, whereas a significant change of summer and autumn precipitation was the major contributor to the annual precipitation trend. Neither precipitation nor temperature increased uniformly across the entire lake drainage basin. The study results identified the most pronounced climate change occurring in the mountainous part (>2000 m above sea level) of the basin, in the upper reaches of the Ili river, which is the main water inflow to the lake. Statistical analysis indicated the Lake Balkhash water level is strongly correlated with both precipitation and temperature. The correlations were investigated for three altitudinal strata (<1000 m, 1000–2000 m, >2000 m) corresponding to the lower, middle and upper reaches of the Ili river. The best correlations were obtained for the upper reaches of the Ili river, indicating a changing snow cover and glacier equilibrium are the main factors controlling the water level trends in Lake Balkhash. 相似文献
992.
Natalia A. Trifonova Roman Kamyshinsky Teodoro Coba de la Pea Maria I. Koroleva Olga Kulikova Victoria Lara-Dampier Pavel Pashkovskiy Mikhail Presniakov Jos J. Pueyo M. Mercedes Lucas Elena E. Fedorova 《International journal of molecular sciences》2022,23(18)
The maintenance of intracellular nitrogen-fixing bacteria causes changes in proteins’ location and in gene expression that may be detrimental to the host cell fitness. We hypothesized that the nodule’s high vulnerability toward salt stress might be due to alterations in mechanisms involved in the exclusion of Na+ from the host cytoplasm. Confocal and electron microscopy immunolocalization analyses of Na+/K+ exchangers in the root nodule showed the plasma membrane (MtNHX7) and endosome/tonoplast (MtNHX6) signal in non-infected cells; however, in mature infected cells the proteins were depleted from their target membranes and expelled to vacuoles. This mistargeting suggests partial loss of the exchanger’s functionality in these cells. In the mature part of the nodule 7 of the 20 genes encoding ion transporters, channels, and Na+/K+ exchangers were either not expressed or substantially downregulated. In nodules from plants subjected to salt treatments, low temperature-scanning electron microscopy and X-ray microanalysis revealed the accumulation of 5–6 times more Na+ per infected cell versus non-infected one. Hence, the infected cells’ inability to withstand the salt may be the integral result of preexisting defects in the localization of proteins involved in Na+ exclusion and the reduced expression of key genes of ion homeostasis, resulting in premature senescence and termination of symbiosis. 相似文献
993.
Eliades Charalambos Lenc Ladislav Král Pavel Papadopoulos Harris 《Machine Learning》2019,108(3):511-534
Machine Learning - Automatic face recognition (AFR) has gained the attention of many institutes and researchers in the past two decades due to its wide range of applications. This attention... 相似文献
994.
Kotyrba Martin Volna Eva Jarusek Robert Smolka Pavel 《Neural computing & applications》2021,33(23):16519-16531
Neural Computing and Applications - This article reflects research in the field of artificial intelligence and demonstrates a higher efficiency achievement of conventional clustering methods in... 相似文献
995.
Laurent Suissa Pavel Kotchetkov Jean-Marie Guigonis Emilie Doche Ophlie Osman Thierry Pourcher Sabine Lindenthal 《International journal of molecular sciences》2021,22(2)
The role of ketone bodies in the cerebral energy homeostasis of neurological diseases has begun to attract recent attention particularly in acute neurological diseases. In ketogenic therapies, ketosis is achieved by either a ketogenic diet or by the administration of exogenous ketone bodies. The oral ingestion of the ketone ester (KE), (R)-3-hydroxybutyl (R)-3-hydroxybutyrate, is a new method to generate rapid and significant ketosis (i.e., above 6 mmol/L) in humans. KE is hydrolyzed into β-hydroxybutyrate (βHB) and its precursor 1,3-butanediol. Here, we investigate the effect of oral KE administration (3 mg KE/g of body weight) on brain metabolism of non-fasted mice using liquid chromatography in tandem with mass spectrometry. Ketosis (Cmax = 6.83 ± 0.19 mmol/L) was obtained at Tmax = 30 min after oral KE-gavage. We found that βHB uptake into the brain strongly correlated with the plasma βHB concentration and was preferentially distributed in the neocortex. We showed for the first time that oral KE led to an increase of acetyl-CoA and citric cycle intermediates in the brain of non-fasted mice. Furthermore, we found that the increased level of acetyl-CoA inhibited glycolysis by a feedback mechanism and thus competed with glucose under physiological conditions. The brain pharmacodynamics of this oral KE strongly suggest that this agent should be considered for acute neurological diseases. 相似文献
996.
Georgy A. Nevinsky Ol'ga D. Zakharova Ivan Yu. Kompaneets Anna M. Timofeeva Pavel S. Dmitrenok Natalia I. Menzorova 《Journal of dairy science》2021,104(6):6431-6448
In the milk of healthy women, antibodies were found with different catalytic activities (abzymes), which are absent in the sera of other healthy people. Moreover, it was previously shown that DNase antibodies-abzymes of patients with autoimmune diseases are cytotoxic to cancer cells. In this work, it was first shown that IgG and secretory IgA (sIgA) do not possess embryotoxicity; they practically do not affect the development of fertilized eggs of sea urchins but demonstrate sperm toxicity. After addition to the eggs of sperm preincubated with IgG and sIgA, the number of unfertilized eggs was increased, in the case of sIgA 1.6-fold higher than that for IgG. The suppression of the growth of MCF-7 breast cancer cells by sIgA was 2.2 times more effective than with IgG antibodies. The relative enzymatic activity of milk sIgA was higher than IgG (-fold): 1.9 (DNase), 4.6 (amylase), 1.7 (peroxidase), 1.3 (protease), 3.7 [hydrolysis of poly(C)], 3.3 [hydrolysis of poly(U)], and 1.7 (oxidation of 3,3′-diaminobenzidine). One of the possible reasons for the observed difference between sIgA and IgG could be that all 6 catalytic activities of sIgA were, on average, 2.6 times higher than that for IgG. Correlation coefficients between all the relative 6 enzymatic activities of IgG and sIgA and their toxicity to sea urchin sperm and to cancer cells were calculated. Maximum correlation coefficients were observed for DNase (+0.71), protease (+0.64) activities for sIgA, as well as protease (+0.59) and RNase (+0.77) of IgG with their toxicity toward sperm. The correlation coefficients were also high between peroxidase activity (+0.85) of sIgA and poly(U) hydrolysis by IgG (+0.58) with their suppression of tumor cell growth. It has been suggested that the catalytic activities of abzymes may be important in the manifestation of their sperm toxicity and inhibition of cancer cell growth. 相似文献
997.
Ivan E. Gorban Mikhail A. Soldatov Vera V. Butova Pavel V. Medvedev Olga A. Burachevskaya Anna Belanova Peter Zolotukhin Alexander V. Soldatov 《International journal of molecular sciences》2020,21(24)
Synthesis of the MIL-100 metal-organic framework particles was carried out by hydrothermal (HT) and microwave (MW)-assisted methods. Transmission electron microscopy showed formation of microparticles in the course of hydrothermal synthesis and nanoparticles for microwave-assisted synthesis. Powder X-ray diffraction confirmed formation of larger crystallites for hydrothermal synthesis. Particle aggregation in aqueous solution was observed by dynamic light scattering. However, the stability of both samples could be improved in acetic acid solution. Nitrogen sorption isotherms showed high porosity of the particles. ᶫ-leucine molecule was used as a model molecule for loading in the porous micro- and nanoparticles. Loading was estimated by FTIR spectroscopy and thermogravimetric analysis. UV-VIS spectroscopy quantified ᶫ-leucine release from the particles in aqueous solution. Cytotoxicity studies using the HeLa cell model showed that the original particles were somewhat toxic, but ᶫ-leucine loading ameliorated the toxic effects, likely due to signaling properties of the amino acid. 相似文献
998.
Osinenko Pavel Devadze Grigory Streif Stefan 《International Journal of Control, Automation and Systems》2020,18(9):2177-2185
International Journal of Control, Automation and Systems - The eigenvalue problem plays a central role in linear algebra and its applications in control and optimization methods. In particular,... 相似文献
999.
Dinara Sobola Pavel Kaspar Pavel Tofel Vladimír Holcman 《Microscopy research and technique》2020,83(2):196-201
Modern day pencil lead is a material of many possibilities. Manufacture process is fast, easy, and well established, yet the full potential of its use still remains to be uncovered. Graphite content ratio to binding clays determines basic properties of the lead like its toughness and color, but more interesting qualities like conductivity and reactivity as well. Properly employed electrochemical etching with a bubble membrane creates sharp and smooth graphite tips, which can be, given enough graphite content, used as probes in several measurement techniques. Observing and adjusting the tip creation process and the results for use in further research are the objectives of this paper. 相似文献
1000.
Wireless Personal Communications - Man has explored less than 5% of three-fourths of the water on Earth. This is mostly due to lack of cheap and effective under-water transportation. Submarines and... 相似文献