Bulk nanocomposite made of ZnO lamellae embedded in the ZnWO4 matrix: growth from the melt

Journal of Materials Science - Zinc oxide (ZnO) nanostructures exhibiting high exciton binding energy and efficient radiative recombination, even at the room temperature, are of increasing interest...     

Dynamic spectrum access in terrestrial TV band: assessment of prospects in Kenya

Wireless connectivity has become a significant part of human life all over the world, both in developing and developed countries. In order to provide sufficient coverage without the densification of cellular networks, relatively low carrier frequencies should be used. This paper considers the reuse of the digital terrestrial television (DTT) band for cellular system operation in Kenya, while protecting incumbent TV signal reception according to the Dynamic Spectrum Alliance (DSAL) rules. A state of the art model for DTT coverage and allowed cellular system power calculation is tested using real data for Kenya. Suggestions regarding future DSAL rules amendments are provided. Moreover, the amount of spectrum resources available for cellular system operation in the DTT band in Kenya is estimated against varying system parameters.

     

Stream-based semi-supervised learning for recommender systems

To alleviate the problem of data sparsity inherent to recommender systems, we propose a semi-supervised framework for stream-based recommendations. Our framework uses abundant unlabelled information to improve the quality of recommendations. We extend a state-of-the-art matrix factorization algorithm by the ability to add new dimensions to the matrix at runtime and implement two approaches to semi-supervised learning: co-training and self-learning. We introduce a new evaluation protocol including statistical testing and parameter optimization. We then evaluate our framework on five real-world datasets in a stream setting. On all of the datasets our method achieves statistically significant improvements in the quality of recommendations.     

Epoxy resin modified with soybean oil containing cyclic carbonate groups

Carbonated soybean oil (CSO) containing five‐membered cyclic carbonate groups has been obtained in the reaction of epoxidized soybean oil with carbon dioxide in the presence of KI activated by 18‐crown‐6 under 6 MPa CO₂ pressure at 130°C. The CSO was used for modification of bisphenol‐A based epoxy resin. The composition epoxide‐cyclic carbonate was cured using polyamine hardeners by one‐step and two‐step procedures. All cured compositions were characterized for their thermal and mechanical properties and compared with the parent epoxy network. The optimal properties were obtained for compositions containing CSO and cured by one‐step method when phase separation takes place. The mechanical properties were discussed in terms of morphology observed by SEM. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 2904‐2914, 2006     

The influence of stylus flight on change of surface topography parameters

Theoretical and experimental work on stylus flight is described. The paper describes the development of a simulation model for assessing the magnitude of surface topography distortion by stylus flight. Experiments on the surfaces support the theoretical model, which predicts stylus flight. The measurements of different surface topographies (including surfaces after grinding, turning, honing, milling) were done using Talyscan 150 measuring instrument with four traversing speeds (0.5, 1, 2 and 3 mm/s). The results of theoretical considerations and experiments were compared. The effect of stylus flight on surface topography parameters of measured surfaces basing on experimental investigation was assessed. The tendency was found that slope decreased, decrease of amplitude parameters and increase of horizontal parameters took place, but these effects were different for various surface types. The simulation procedure assured good accuracy of surface topography parameters changes.Based on theoretical investigation, the effect of stylus flight and stylus tip radius on parameters of computer-generated profiles was predicted. The choice of traversing speed to different types of surfaces was done. The parameters of biggest changes caused by error in measurement due to stylus kinematics were selected.     

A dynamic call admission scheme for VBR traffic in ATM networks

The role of call admission control (CAC) in high-speed networks is to maintain the network utilization at a high level, while ensuring that the quality of service (QoS) requirements of the individual calls are met. We use the term static CAC to describe schemes that always allocate the same bandwidth to a specific group of multiplexed calls, independent of the other traffic sharing the link. Dynamic CAC, on the other hand, denotes a scheme in which the bandwidth allocation to a group of calls sharing a queue is influenced by the traffic in other queues destined for the same outgoing link. We propose a generic dynamic call admission scheme for VBR and ABR traffic whose aim is to reduce the blocking rate for VBR calls at the expense of a higher blocking rate for ABR calls. Our scheme is generic because it builds up on a pre-existing static scheme, e.g., one based on a simple notion of effective bandwidth. Our simple approach results in a significant reduction of the blocking rate for VBR traffic (several orders of magnitude), if the bandwidth requirements of a single call are a reasonably small fraction of the link capacity. At the same time, the deterioration of service for ABR traffic can be contained. This revised version was published online in August 2006 with corrections to the Cover Date.     

Road to Metastasis: The TWEAK Pathway as a Discriminant between Metastasizing and Non-Metastasizing Thick Melanomas

Cutaneous melanoma (CM) is the most aggressive form of skin cancer, and its worldwide incidence is rapidly increasing. Early stages can be successfully treated by surgery, but once metastasis has occurred, the prognosis is poor. However, some 5–10% of thick (≥2 mm) melanomas do not follow this scenario and run an unpredictable course. Little is known about the factors that contribute to metastasis in some patient with thick melanomas and the lack thereof in thick melanoma patients who never develop metastatic disease. We were therefore interested to study differential gene expression and pathway analysis and compare non-metastatic and metastatic thick melanomas. We found that the TNF-like weak inducer of apoptosis (TWEAK) pathway was upregulated in thick non-metastasizing melanomas. MAP3K14 (NIK1), BIRC2 (cIAP1), RIPK1, CASP7, CASP8, and TNF play an important role in inhibiting proliferation and invasion of tumor cells via the activation of the non-canonical NF-κB signaling pathway. In particular, this pathway sensitizes melanoma cells to TNF-alpha and activates the apoptosis module of the TWEAK pathway in thick non-metastasizing melanomas. Hence, our study suggests a potential role of the TWEAK pathway in inhibiting thick melanoma from metastasis. Exploitation of these genes and the pathway they control may open future therapeutic avenues.     

The Mutation in wbaP cps Gene Cluster Selected by Phage-Borne Depolymerase Abolishes Capsule Production and Diminishes the Virulence of Klebsiella pneumoniae

Klebsiella pneumoniae is considered one of the most critical multidrug-resistant pathogens and urgently requires new therapeutic strategies. Capsular polysaccharides (CPS), lipopolysaccharides (LPS), and exopolysaccharides (EPS) are the major virulence factors protecting K. pneumoniae against the immune response and thus may be targeted by phage-based therapeutics such as polysaccharides-degrading enzymes. Since the emergence of resistance to antibacterials is generally considered undesirable, in this study, the genetic and phenotypic characteristics of resistance to the phage-borne CPS-degrading depolymerase and its effect on K. pneumoniae virulence were investigated. The K63 serotype targeting depolymerase (KP36gp50) derived from Klebsiella siphovirus KP36 was used as the selective agent during the treatment of K. pneumoniae 486 biofilm. Genome-driven examination combined with the surface polysaccharide structural analysis of resistant mutant showed the point mutation and frameshift in the wbaP gene located within the cps gene cluster, resulting in the loss of the capsule. The sharp decline in the yield of CPS was accompanied by the production of a larger amount of smooth LPS. The modification of the surface polysaccharide layers did not affect bacterial fitness nor the insensitivity to serum complement; however, it made bacteria more prone to phagocytosis combined with the higher adherence and internalization to human lung epithelial cells. In that context, it was showed that the emerging resistance to the antivirulence agent (phage-borne capsule depolymerase) results in beneficial consequences, i.e., the sensitization to the innate immune response.     

Programming of Embryonic Development

Assisted reproductive techniques (ART) and parental nutritional status have profound effects on embryonic/fetal and placental development, which are probably mediated via “programming” of gene expression, as reflected by changes in their epigenetic landscape. Such epigenetic changes may underlie programming of growth, development, and function of fetal organs later in pregnancy and the offspring postnatally, and potentially lead to long-term changes in organ structure and function in the offspring as adults. This latter concept has been termed developmental origins of health and disease (DOHaD), or simply developmental programming, which has emerged as a major health issue in animals and humans because it is associated with an increased risk of non-communicable diseases in the offspring, including metabolic, behavioral, and reproductive dysfunction. In this review, we will briefly introduce the concept of developmental programming and its relationship to epigenetics. We will then discuss evidence that ART and periconceptual maternal and paternal nutrition may lead to epigenetic alterations very early in pregnancy, and how each pregnancy experiences developmental programming based on signals received by and from the dam. Lastly, we will discuss current research on strategies designed to overcome or minimize the negative consequences or, conversely, to maximize the positive aspects of developmental programming.