Diagnosis of lung nodule using Moran’s index and Geary’s coefficient in computerized tomography images

This paper analyzes the application of Moran’s index and Geary’s coefficient to the characterization of lung nodules as malignant or benign in computerized tomography images. The characterization method is based on a process that verifies which combination of measures, from the proposed measures, has been best able to discriminate between the benign and malignant nodules using stepwise discriminant analysis. Then, a linear discriminant analysis procedure was performed using the selected features to evaluate the ability of these in predicting the classification for each nodule. In order to verify this application we also describe tests that were carried out using a sample of 36 nodules: 29 benign and 7 malignant. A leave-one-out procedure was used to provide a less biased estimate of the linear discriminator’s performance. The two analyzed functions and its combinations have provided above 90% of accuracy and a value area under receiver operation characteristic (ROC) curve above 0.85, that indicates a promising potential to be used as nodules signature measures. The preliminary results of this approach are very encouraging in characterizing nodules using the two functions presented.

Dissimilarity-based classification of chromatographic profiles

This paper proposes a non-parametric method for the classification of thin-layer chromatographic (TLC) images from patterns represented in a dissimilarity space. Each pattern corresponds to a mixture of Gaussian approximation of the intensity profile. The methodology comprises various phases, including image processing and analysis steps to extract the chromatographic profiles and a classification phase to discriminate among two groups, one corresponding to normal cases and the other to three pathological classes. We present an extensive study of several dissimilarity-based approaches analysing the influence of the dissimilarity measure and the prototype selection method on the classification performance. The main conclusions of this paper are that, Match and Profile-difference dissimilarity measures present better results, and a new prototype selection methodology achieves a performance similar or even better than conventional methods. Furthermore, we also concluded that simplest classifiers, such as k-NN and linear discriminant classifiers (LDCs), present good performance being the overall classification error less than 10% for the four-class problem.     

Device for characterization of thermal effusivity of liquids using photothermal beam deflection

We propose and study a novel optoelectronic device for thermal characterization of materials. It is based on monitoring the photothermal deflection of a laser beam within a slab of a thermo-optic material in thermal contact with the sample under study. An optical angle sensor is used to measure the laser deflection providing a simple and experimental arrangement. We demonstrate its principle and a simple procedure to measure thermal effusivity of liquids. The proposed device could be implemented into a compact sensor head for remote measurements using electrical and fiber optic links.     

An Approach for Recovering Distributed System Architectures

Reasoning about software systems at the architectural level is key to effective software development, management, evolution and reuse. All too often, though, the lack of appropriate documentation leads to a situation where architectural design information has to be recovered directly from implemented software artifacts. This is a very demanding process, particularly when involving recovery of runtime abstractions (clients, servers, interaction protocols, etc.) that are typical to the design of distributed software systems. This paper presents an exploratory reverse engineering approach, called X-ray, to aid programmers in recovering architectural runtime information from a distributed system's existing software artifacts. X-ray comprises three domain-based static analysis techniques, namely component module classification, syntactic pattern matching, and structural reachability analysis. These complementary techniques can facilitate the task of identifying a distributed system's implemented executable components and their potential runtime interconnections. The component module classification technique automatically distinguishes source code modules according to the executables components they implement. The syntactic pattern matching technique in turn helps to recognise specific code fragments that may implement typical component interaction features. Finally, the structural reachability analysis technique aids in the association of those features to the code specific for each executable component. The paper describes and illustrates the main concepts underlying each technique, reports on their implementation as a suit of new and off-the-shelf tools, and, to give evidence of the utility of the approach, provides a detailed account of a successful application of the three techniques to help recover a static approximation of the runtime architecture for Field, a publicly-available distributed programming environment.     

CASANDRA: a prototype implementation of a system of network progressive transmission of medical digital images

In this paper, a prototype for progressive transmission of medical digital 2D images through the network, called CASANDRA, is presented. The prototype consists of the server part and the client part. In the server part, the images are acquired, stored, computed their wavelet transform and the wavelet coefficients stored, then transmitted progressively, when required, via TCP to the client. In the client part, with the inverse wavelet transform, the received wavelet coefficients are used to build successive improved reconstructions of the image.This prototype has been implemented and is being tested in the Radiotherapy Service of the Valencia University Hospital (Valencia, Spain).     

Guidance of a mobile robot using an array of static cameras located in the environment

This paper presents a new proposal for positioning and guiding mobile robots in indoor environments. The proposal is based on the information provided by static cameras located in the movement environment. This proposal falls within the scope of what are known as intelligent environments; in this case, the environment is provided with cameras that, once calibrated, allow the position of the robots to be obtained. Based on this information, control orders for the robots can be generated using a radio frequency link. In order to facilitate identification of the robots, even under extremely adverse ambient lighting conditions, a beacon consisting of four circular elements constructed from infrared diodes is mounted on board the robots. In order to identify the beacon, an edge detection process is carried out. This is followed by a process that, based on the algebraic distance, obtains the estimated ellipses associated with each element of the beacon. Once the beacon has been identified, the coordinates of the centroids for the elements that make up the beacon are obtained on the various image planes. Based on these coordinates, an algorithm is proposed that takes into account the standard deviation of the error produced in the various cameras in ascertaining the coordinates of the beacon’s elements. An odometric system is also used in guidance that, in conjunction with a Kalman Filter, allows the position of the robot to be estimated during the time intervals required to process the visual information provided by the cameras.

Arity and alternation: a proper hierarchy in higher order logics

We study the effect of simultaneously bounding the maximal-arity of the higher-order variables and the alternation of quantifiers in higher-order logics, as to their expressive power on finite structures (or relational databases). Let $\mathit{AA}^i(r,m)$ be the class of (i?+?1)-th order logic formulae where all quantifiers are grouped together at the beginning of the formulae, forming m alternating blocks of consecutive existential and universal quantifiers, and such that the maximal-arity (a generalization of the concept of arity, not just the maximal of the arities of the quantified variables) of the higher-order variables is bounded by r. Note that, the order of the quantifiers in the prefix may be mixed. We show that, for every i?≥?1, the resulting $\mathit{AA}^i(r,m)$ hierarchy of formulae of (i?+?1)-th order logic is proper. This extends a result by Makowsky and Pnueli who proved that the same hierarchy in second-order logic is proper. In both cases the strategy used to prove the results consists in considering formulae which, represented as finite structures, satisfy themselves. As the well known diagonalization argument applies here, this gives rise, for each order i and each level of the $\mathit{AA}^i(r,m)$ hierarchy of arity and alternation, to a class of formulae which is not definable in that level, but which is definable in a higher level of the same hierarchy. We then use a similar argument to prove that the classes of $\Sigma^i_m \cup \Pi^i_m$ formulae in which the higher-order variables of all orders up to i?+?1 have maximal-arity at most r, also induce a proper hierarchy in each higher-order logic of order i?≥?3. It is not known whether the correspondent hierarchy in second-order logic is proper. Using the concept of finite model truth definitions introduced by M. Mostowski, we give a sufficient condition for that to be the case.     

Local Stability of an Endoreversible Heat Engine Working in an Ecological Regime

We present a local stability analysis of an endoreversible engine working in an ecological regime, for three common heat transfer laws. From our local stability analysis we conclude that the system is stable for every value of the heat conductivity g, the heat capacity C and the ratio of temperatures with T ₁ > T ₂. After a small perturbation the system decays exponentially to the steady state determined by two different relaxation times. We observe that the stability of the system improves as increases whereas the steady-state energetic properties of the engine decline. Moreover, we compare the stability properties of the engine working in the ecological regime and under maximum power output. Finally, qualitative phase-space portraits for the evolution of the system are presented for representative cases.     

Analysis of the HLA class I associated peptide repertoire in a hepatocellular carcinoma cell line reveals tumor-specific peptides as putative targets for immunotherapy

HLA class I molecules present peptides on the cell surface to CD8(+) T cells. The repertoire of peptides that associate to class I molecules represents the cellular proteome. Therefore, cells expressing different proteomes could generate different class I-associated peptide repertoires. A large number of peptides have been sequenced from HLA class I alleles, mostly from lymphoid cells. On the other hand, T cell immunotherapy is a goal in the fight against cancer, but the identification of T cell epitopes is a laborious task. Proteomic techniques allow the definition of putative T cell epitopes by the identification of HLA natural ligands in tumor cells. In this study, we have compared the HLA class I-associated peptide repertoire from the hepatocellular carcinoma (HCC) cell line SK-Hep-1 with that previously described from lymphoid cells. The analysis of the peptide pool confirmed that, as expected, the peptides from SK-Hep-1 derive from proteins localized in the same compartments as in lymphoid cells. Within this pool, we have identified 12 HLA class I peptides derived from HCC-related proteins. This confirms that tumor cell lines could be a good source of tumor associated antigens to be used, together with MS, to define putative epitopes for cytotoxic T cells from cancer patients.