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排序方式: 共有220条查询结果,搜索用时 218 毫秒
211.
Pere Grima Lourdes Rodero Xavier Tort-Martorell 《Quality and Reliability Engineering International》2020,36(7):2370-2378
Industrial contexts tend to be as much or more concerned about the probability of ignoring an effect when its influence on the response is relevant (Type II error) than about the probability of considering an effect to be active when in fact, it is not (Type I error). Here, we present a methodology for taking into account both types of error by fixing an effect value that is considered large enough to control the probability of it going unnoticed. In addition, we propose a plot to visualize the results obtained. 相似文献
212.
Dr. Karel Hernández Dr. Anna Szekrenyi Prof. Dr. Pere Clapés 《Chembiochem : a European journal of chemical biology》2018,19(13):1353-1358
The asymmetric aldol addition reaction mediated by aldolases is recognized as a green and sustainable method for carbon–carbon bond formation. Research in this area has unveiled their unprecedented synthetic potential toward diverse, new chemical structures; novel product families; and even as a technology for industrial manufacturing processes. Despite these advances, aldolases have long been regarded as strictly selective catalysts, particularly for nucleophilic substrates, which limits their broad applicability. In recent years, advances in screening technologies and metagenomics have uncovered novel C?C biocatalysts from superfamilies of widely known lyases. Moreover, protein engineering has revealed the extraordinary malleability of different carboligases to offer a toolbox of biocatalysts active towards a large structural diversity of nucleophile substrates. Herein, the nucleophile ambiguity of native and engineered aldolases is discussed with recent examples to prove this novel concept. 相似文献
213.
Isarain-Chávez E Cabot PL Centellas F Rodríguez RM Arias C Garrido JA Brillas E 《Journal of hazardous materials》2011,185(2-3):1228-1235
The beta-blocker propranolol hydrochloride has been degraded by electrochemical advanced oxidation processes like electro-Fenton (EF) and photoelectro-Fenton (PEF) using a single cell with a Pt anode and an air diffusion cathode (ADE) for H(2)O(2) electrogeneration and a combined system containing the above Pt/ADE pair coupled in parallel to a Pt/carbon-felt (CF) cell. Organics are mainly oxidized with hydroxyl radical (OH) formed from Fenton's reaction between added Fe(2+) and electrogenerated H(2)O(2). The PEF treatment in Pt/ADE-Pt/CF system yields almost total mineralization because OH production is enhanced by Fe(2+) regeneration from Fe(3+) reduction at the CF cathode and Fe(III) complexes with generated carboxylic acids are rapidly photodecarboxylated under UVA irradiation. Lower mineralization degree is found for PEF in Pt/ADE cell due to the little influence of UVA light on Fe(2+) regeneration. The homologous EF processes are much less potent as a result of the persistence of Fe(III)-carboxylate complexes. Aromatic intermediates such as 1-naphthol, 1,4-naphthoquinone and phthalic acid and generated carboxylic acids such as pyruvic, glycolic, malonic, maleic, oxamic, oxalic and formic are identified. While chloride ion remains stable, NH(4)(+) and NO(3)(-) ions are released to the medium. A reaction sequence for propranolol hydrochloride mineralization is proposed. 相似文献
214.
Guillermo de León Pere Grima Xavier Tort‐Martorell 《Quality and Reliability Engineering International》2011,27(4):489-497
When the results of an experimental design are analyzed, in which control factors and noise factors are involved, it may be difficult to determine the combination of values of the control factors that produce the best behavior of the response, addressing both its level (or distance from the target value) and its variability. This article presents an analysis proposal that is based on the model obtained for the response and uses, as its central element, a scatter plot of its expected value vs its standard deviation. In this plot, each point corresponds to a combination of values of the control factors; thus, it is easy to identify the points with better response behavior. In our opinion, this graph provides significant advantages over the other methods that have been proposed; among them is the fact that it is always a scatter plot, regardless of the number of factors that end up being active, and that it is easy to understand and use, especially with the possibilities offered by the current statistical software packages. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
215.
Increase of load‐carrying capacity of masonry with textile reinforced rendering / Erhöhung der Tragfähigkeit von Mauerwerk mit textilbewehrtem Putz
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Assit. Prof. Catherine Papanicolaou Prof. Thanasis C. Triantafillou Prof. Pere Roca Fabregat 《Mauerwerk》2015,19(1):40-51
Contemporary externally bonded structural upgrading schemes for masonry structures employ Fiber Reinforced Polymer (FRP) systems (a technique that was extended from concrete to masonry structures) and technical textiles (structural fiber grids) embedded in inorganic matrices. The latter account for a multitude of systems depending on the type of grid – fiber material, bundle treatment (dry, coated or even impregnated), grid geometry, manufacturing method etc. – and matrix – binder (e.g. cement or lime), rheology etc. – resulting in the derivation of many different acronyms (FRCM, TRM, CMG, IMG or other – see for definitions below). The mechanical behavior of such systems and their interaction with different substrates may vary significantly (e.g. dry vs. impregnated fiber grids embedded in mortars). This paper aims to summarize all reported efforts to increase the load‐carrying and/or deformation capacity of unreinforced masonry walls against in‐plane loading and second‐order phenomena (eccentric compressive loading). 相似文献
216.
Pere Llimós Muntal Dennis Øland Larsen Ivan H. H. Jørgensen Erik Bruun 《Analog Integrated Circuits and Signal Processing》2015,83(3):343-352
In this paper a high-voltage transmitting circuit aimed for capacitive micromachined ultrasonic transducers (CMUTs) used in scanners for medical applications is designed and implemented in a 0.35 \(\upmu\)m high-voltage CMOS process. The transmitting circuit is reconfigurable externally making it able to drive a wide variety of CMUTs. The transmitting circuit can generate several pulse shapes with voltages up to 100 V, maximum pulse range of 50 V, frequencies up to 5 MHz and different driving slew rates. Measurements are performed on the circuit in order to assess its functionality and power consumption performance. The design occupies an on-chip area of 0.938 mm\(^{2}\) and the power consumption of a 128-element transmitting circuit array that would be used in an portable ultrasound scanner is found to be a maximum of 181 mW. 相似文献
217.
Skrlep M Candek-Potokar M Mandelc S Javornik B Gou P Chambon C Santé-Lhoutellier V 《Meat science》2011,88(4):657-667
Two-dimensional electrophoresis was used to compare dry-cured biceps femoris insoluble protein fraction according to genotype (PRKAG3Ile199Val and CASTLys249Arg/Ser638Arg) as well as salt and pastiness level. The PRKAG3 affected mainly muscle metabolic enzymes, indicating its possible influence on muscle metabolism with heterozygotes Ile/Val appearing different from both homozygous genotypes. The effect of CAST was smaller, affecting the quantity of one actin fragment. Dry-cured ham salt and pastiness level affected a wide variety of protein spots including metabolic enzymes, plasma proteins, chaperones and myofibrillar proteins, including protein fragments, indicating the connection with proteolysis. Pastiness was associated with salt content, reflected also by the fact that many spots were affected by both factors. Despite the absence of extreme pastiness (or low salt samples), some protein spots (actin, MHC fragment, desmin fragment) exhibited important differences in intensity according to pastiness (and salt level) suggesting they could be used as potential quality markers. 相似文献
218.
Jenifer Masip Rosa Jorba Miguel Lpez-Dupla Pere Domingo Yolanda María Pacheco Graciano García-Pardo Esteban Martínez Consuelo Vilads Sergi Veloso Vernica Alba Montserrat Olona Francesc Vidal Frederic Gmez-Bertomeu Joaquim Peraire Anna Rull 《International journal of molecular sciences》2022,23(15)
Nuclear magnetic resonance (NMR)-based advanced lipoprotein tests have demonstrated that LDL and HDL particle numbers (LDL-P and HDL-P) are more powerful cardiovascular (CV) risk biomarkers than conventional cholesterol markers. Of interest, in people living with HIV (PLHIV), predictors of preclinical atherosclerosis and vascular dysfunction may be associated with impaired immune function. We previously stated that immunological non-responders (INR) were at higher CV risk than immunological responders (IR) before starting antiretroviral therapy (ART). Using Liposcale® tests, we characterized the lipoprotein profile from the same cohort of PLHIV at month 12 and month 36 after starting ART, intending to explore what happened with these indicators of CV risk during viral suppression. ART initiation dissipates the differences in lipoprotein-based CV risk markers between INR and IR, and only an increase in the number of HDL-P was found in INR + IR when compared to controls (p = 0.047). Interestingly, CD4+ T-cell counts negatively correlated with medium HDL-P concentrations at month 12 in all individuals (ρ = −0.335, p = 0.003). Longitudinal analyses showed an important increase in LDL-P and HDL-P at month 36 when compared to baseline values in both IR and INR. A proper balance between a proatherogenic and atherogenic environment may be related to the reconstitution of CD4+ T-cell count in PLHIV. 相似文献
219.
Jordi Guiteras Elena Crespo Pere Fontova Nuria Bolaos Montse Gom Esther Castao Oriol Bestard Josep M. Griny Joan Torras 《International journal of molecular sciences》2022,23(15)
Systemic lupus erythematosus is a complex autoimmune disorder mostly mediated by B-cells in which costimulatory signals are involved. This immune dysregulation can cause tissue damage and inflammation of the kidney, resulting in lupus nephritis and chronic renal failure. Given the previous experience reported with CTLA4-Ig as well as recent understanding of the PD-1 pathway in this setting, our group was encouraged to evaluate, in the NZBWF1 model, a human fusion recombinant protein (Hybri) with two domains: CTLA4, blocking the CD28—CD80 costimulatory pathway, and PD-L2, exacerbating the PD-1–PD-L2 coinhibitory pathway. After achieving good results in this model, we decided to validate the therapeutic effect of Hybri in the more severe MRL/lpr model of lupus nephritis. The intraperitoneal administration of Hybri prevented the progression of proteinuria and anti-dsDNA antibodies to levels like those of cyclophosphamide and reduced the histological score, infiltration of B-cells, T-cells, and macrophages and immune deposition in both lupus-prone models. Additionally, Hybri treatment produced changes in both inflammatory-related circulating cytokines and kidney gene expression. To summarize, both in vivo studies revealed that the Hybri effect on costimulatory-coinhibitory pathways may effectively mitigate lupus nephritis, with potential for use as a maintenance therapy. 相似文献
220.
Letian Dai Pere Roca i Cabarrocas Huaxia Ban Zhiguo Zhang Qiang Sun Xiongjie Li Anjie Gu Wanpeng Yang Haixuan Yu Yan Shen Mingkui Wang 《Small (Weinheim an der Bergstrasse, Germany)》2023,19(22):2208062
This work reports for the first time a highly efficient single-crystal cesium tin triiodide (CsSnI3) perovskite nanowire solar cell. With a perfect lattice structure, low carrier trap density (≈5 × 1010 cm−3), long carrier lifetime (46.7 ns), and excellent carrier mobility (>600 cm2 V−1 s−1), single-crystal CsSnI3 perovskite nanowires enable a very attractive feature for flexible perovskite photovoltaics to power active micro-scale electronic devices. Using CsSnI3 single-crystal nanowire in conjunction with highly conductive wide bandgap semiconductors as front-surface-field layers, an unprecedented efficiency of 11.7% under AM 1.5G illumination is achieved. This work demonstrates the feasibility of all-inorganic tin-based perovskite solar cells via crystallinity and device-structure improvement for the high-performance, and thus paves the way for the energy supply to flexible wearable devices in the future. 相似文献