Recent advances in steel cleanliness

At Klöckner Edelstahl in Georgsmarienhütte improvements in steel cleanliness mentioned in this report were concentrated on the tundish and pouring channel. Sealing of the tundish with inert gas curbed reoxidation so that total oxygen after about 1 minute of casting was around 10 ppm, whereas this value was reached only after 25 minutes of casting in the case without inert gas sealing. Reoxidation in the pouring channel may be a danger because of the high pressure drops recorded. Therefore, stringent measures must be observed to prevent reoxidation in the tundish and the pouring channel.     

Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa

Desmosomes are highly organized intercellular adhesive junctions that are particularly prominent in epidermis and other tissues experiencing mechanical stress. Desmoplakin, a constitutive component of the desmosomal plaque, is the most abundant protein present in such junctions and plays a critical role in linking the intermediate filament network to the plasma membrane in these tissues. Here we report the first mutation in the gene encoding desmoplakin. The identified mutation, resulting in a null allele and haploinsufficiency, was observed in genomic DNA from a kindred with the dominantly inherited skin disorder, striate palmoplantar keratoderma. Affected individuals had a linear pattern of skin thickening on the fingers and palms and circumscribed areas of skin thickening on the soles. Affected skin demonstrated loosening of intercellular connections, disruption of desmosome-keratin intermediate filament interactions and a proportion of rudimentary desmosomal structures. The disorder mapped to chromosome 6p21 with a maximum lod score of 10.67. The mutation was a heterozygous C-->T transition in exon 4 of the desmoplakin gene and predicted a premature termination codon in the N-terminal region of the peptide. This is the first reported mutation of desmo-plakin and also the first inherited skin disorder in which haploinsufficiency of a structural component has been implicated. It identifies dosage of desmoplakin as critical in maintaining epidermal integrity.     

An Innovative Power-Gating Technique for Leakage and Ground Bounce Control in System-on-a-Chip (SOC)

Leakage has become one of the most dominant factors of power consumption and signal integrity of nanometer-scale integrated circuits. Recently, power-gating structures have proven to be effective in controlling leakage. In this paper an alternative dual-V _th reduced power-gating structure is proposed for better reduction of leakage currents, especially for low-power and high-performance portable devices. The proposed technique maintains an intermediate power-saving state as well as the conventional power cut-off state. The experimental results have demonstrated that the proposed technique can significantly reduce leakage current and associated power consumptions during the HOLD and CUT-OFF modes. In addition, an analysis of ground bounce due to power-mode transition in power-gating structures is presented. It is demonstrated that the proposed technique provides a way to control ground bounce during power-mode transition. Due to the presence of the intermediate state, its stepwise turning on feature will provide higher reduction of the magnitudes of peak current and voltage glitches in the power distribution network as well as the minimum time required to stabilize power and ground as compared to other similar techniques.     

PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application

High-frequency needle ultrasound transducers with an aperture size of 0.4 mm were fabricated using lead magnesium niobate-lead titanate (PMN-33% PT) as the active piezoelectric material. The active element was bonded to a conductive silver particle matching layer and a conductive epoxy backing through direct contact curing. An outer matching layer of parylene was formed by vapor deposition. The active element was housed within a polyimide tube and a 20-gauge needle housing. The magnitude and phase of the electrical impedance of the transducer were 47 omega and -38 degrees, respectively. The measured center frequency and -6 dB fractional bandwidth of the PMN-PT needle transducer were 44 MHz and 45%, respectively. The two-way insertion loss was approximately 15 dB. In vivo high-frequency, pulsed-wave Doppler patterns of blood flow in the posterior portion and in vitro ultrasonic backscatter microscope (UBM) images of the rabbit eye were obtained with the 44-MHz needle transducer.     

A new rectangular window based image cropping method for generalization of brain neoplasm classification systems

Classification of brain neoplasm images is one of the most challenging research areas in the field of medical image processing. The main objective of this study is to design a brain neoplasm classification system that can be trained using multiple various sized MR images of different institutions. The proposed method is a generalized classification system; it can be used in a single institute or in a number of institutions at the same time, without any restriction on image size. The generalization and unbiased capability of the proposed method can bring researchers on a single platform to work on some standard forms of computer aided diagnosis system with more efficient diagnostic capabilities. In this study, a suitable size of moveable rectangular window is used between segmentation and feature extraction stages. A semiautomatic, localized region based active contour method is used for segmentation of brain neoplasm region. Discrete wavelet transform for feature extraction, principal component analysis for feature selection and support vector machine is used as classifier. For the first time MR images of 2 sizes and from different institutions are used in training and testing of brain neoplasm classifier. Three glioma grades were classified using 92 MR images. The proposed method achieved the highest accuracy of 88.26%, the highest sensitivity of 92.23% and the maximum specificity of 93.93%. In addition, the proposed method is computationally less complex, requires shorter processing time and is more efficient in terms of storage capacity.     

Internationalisation for Survival: The Case of New Ventures

The aim is to deepen our understanding about the internationalisation–survival relationship in the case of new ventures in traditional manufacturing sectors. Hypotheses were tested through Cox’s proportional hazard regressions on a sample of 3,350 firms aged 10 years or less, from the textile-clothing and footwear industry in Spain. A vast majority of new ventures that were both established and closed down over that time are purely domestic firms. That means, a firm increases its likelihood of survival when it becomes international. The highest failure risk relates to those new ventures which are territorially agglomerated and are domestically oriented. Internationalisation is an unconditional strategy for surviving in the case of new manufacturing ventures. In addition, location and efficiency in the activity both matter when operating in international markets. Statistical tests show that an interactive effect of agglomeration and internationalisation exists, while no support for the interaction between age and internationalisation is found. Future research should investigate the trade-off between growth and survival forces to determine the optimum moment to go international and to characterise the strategic choices followed by those new ventures that survive longest.     

Role of Fuzzy Approach towards Fault Detection for Distributed Components

Component-based software development is rapidly introducing numerous new paradigms and possibilities to deliver highly customized software in a distributed environment. Among other communication, teamwork, and coordination problems in global software development, the detection of faults is seen as the key challenge. Thus, there is a need to ensure the reliability of component-based applications requirements. Distributed device detection faults applied to tracked components from various sources and failed to keep track of all the large number of components from different locations. In this study, we propose an approach for fault detection from component-based systems requirements using the fuzzy logic approach and historical information during acceptance testing. This approach identified error-prone components selection for test case extraction and for prioritization of test cases to validate components in acceptance testing. For the evaluation, we used empirical study, and results depicted that the proposed approach significantly outperforms in component selection and acceptance testing. The comparison to the conventional procedures, i.e., requirement criteria, and communication coverage criteria without irrelevancy and redundancy successfully outperform other procedures. Consequently, the F-measures of the proposed approach define the accurate selection of components, and faults identification increases in components using the proposed approach were higher (i.e., more than 80 percent) than requirement criteria, and code coverage criteria procedures (i.e., less than 80 percent), respectively. Similarly, the rate of fault detection in the proposed approach increases, i.e., 92.80 compared to existing methods i.e., less than 80 percent. The proposed approach will provide a comprehensive guideline and roadmap for practitioners and researchers.     

Vibration of clamped moderately thick general cross-ply plates using a generalized Navier approach

A hitherto unavailable analytical solution to the free vibration problem of general cross-ply laminated rigidly clamped rectangular plates, incorporating first-order shear deformation, and rotatory and in-plane inertias into the formulation, is presented. A recently developed boundary continuous displacement-based generalized Navier solution technique is used to solve the five highly coupled linear second-order partial differential equations with constant coefficients, and the associated geometric boundary conditions. The assumed solution functions are in the form of double Fourier series, which satisfy the rigidly clamped boundary conditions a priori in a manner similar to the conventional Navier method. Convergence characteristics of the natural frequencies of both symmetric and antisymmetric cross-ply plates are numerically established. Other numerical results presented herein include (i) comparison with the corresponding available first-order shear deformation theory-based Galerkin and classical lamination theory-based boundary-discontinuous analytical solutions, and (ii) study of the effects of thickness and aspect ratio on the natural frequencies.