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61.
Journal of Computer Virology and Hacking Techniques - With macOS increasing popularity, the number, and variety of macOS malware are rising as well. Yet, very few tools exist for dynamic analysis... 相似文献
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Dr. Jakob Franke Dr. Jeongwoon Kim John P. Hamilton Dr. Dongyan Zhao Gina M. Pham Krystle Wiegert-Rininger Emily Crisovan Linsey Newton Brieanne Vaillancourt Dr. Evangelos Tatsis Prof. Dr. C. Robin Buell Prof. Dr. Sarah E. O'Connor 《Chembiochem : a European journal of chemical biology》2019,20(1):83-87
Genome mining is a routine technique in microbes for discovering biosynthetic pathways. In plants, however, genomic information is not commonly used to identify novel biosynthesis genes. Here, we present the genome of the medicinal plant and oxindole monoterpene indole alkaloid (MIA) producer Gelsemium sempervirens (Gelsemiaceae). A gene cluster from Catharanthus roseus, which is utilized at least six enzymatic steps downstream from the last common intermediate shared between the two plant alkaloid types, is found in G. sempervirens, although the corresponding enzymes act on entirely different substrates. This study provides insights into the common genomic context of MIA pathways and is an important milestone in the further elucidation of the Gelsemium oxindole alkaloid pathway. 相似文献
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Applied Intelligence - Recommendation systems play an important role in boosting purchasing consumption for many manufacturers by helping consumers find the most appropriate items. Furthermore,... 相似文献
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Diem-Huong Nguyen Tran Thi Hiep Nguyen Thanh Nguyet Nguyen Vo Linh Phuong Tran Pham Do Minh Hoang Vo Cuu Khoa Nguyen Long Giang Bach Dai Hai Nguyen 《应用聚合物科学杂志》2019,136(20):47544
Curcumin (CUR) is a natural active ingredient that attracted much attention for its chemotherapeutic activity against tumors without causing toxicity in healthy cells. However, it has certain limitations for being used in chemotherapy such as low aqueous solubility and hydrolytic instability in the physiological environment. In this study, self-assembled poly(ethylene glycol) methyl ether-grafted gelatin (Gel-mPEG) nanogels were fabricated as delivery systems to improve the applicability of CUR in cancer treatment. CUR-loaded Gel-mPEG nanogels exhibited desired size range, relatively colloidal stability, and provided enhanced CUR stability in aqueous solutions. Especially, they showed significant high CUR loading capacity and better anticancer activity than free CUR as compared to previously reported CUR-loaded nanogels according to the best of our knowledge. Moreover, the in vitro release of CUR from the nanogels was controlled and prolonged up to 96 h. These results demonstrated that Gel-mPEG nanogels are the promising modality for the efficient delivery of CUR in cancer treatment. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019 , 136, 47544. 相似文献
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Viet Hung Pham Thanh Truong Dang Tran Viet Cuong Seung Hyun Hur Byung-Seon Kong Eui Jung Kim Jin Suk Chung 《Korean Journal of Chemical Engineering》2012,29(5):680-685
We report the effect of temperature on the extent of graphene oxide reduction by hydrazine and the dispersibility of the resulting
chemically converted graphene (CCG) in polar organic solvents. The extent of graphene oxide reduction at high temperatures
was only slightly higher than at low temperatures (30–50 °C), while the dispersibility of the resulting CCG in organic solvents
decreased markedly with increasing temperature. The low dispersibility of CCGs prepared at high temperatures was greatly affected
by reduction and influenced by the formation of an irreversible agglomerate of CCG at high temperatures. The reduction of
graphene oxide at low temperatures is necessary to prepare highly dispersible CCG in organic solvents. CCG prepared at 30
°C is dispersible in N-methyl-2-pyrrolidone concentrations as high as 0.71 mg/mL. The free-standing paper made of this CCG
possessed an electrical conductivity of more than 22,000 S/m, one of the highest values ever reported. 相似文献
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Bulk ultrafine-grained nickel specimens having grain sizes in the range of 0.25-5 μm were consolidated by hot isostatic pressing technique. The resulting microstructures were characterized by transmission electron microscopy and X-ray diffraction analysis. Compression tests were carried out at room temperature and at strain rate of 1.6×10−4 s−1. It was found that the measured yield strength does not follow the Hall-Petch law as a consequence of the presence of oxide phase. Therefore, the use of micromechanics based model, which takes into account only the Hall-Petch relationship at grain level for predicting the grain sized effects on mechanical behavior of this kind of materials, is not accurate yet. In this study, a modification made to the generalized self-consistent model was proposed for studying both grain size and oxide phase dependence of ultrafine-grained materials behavior. Because of the novel modification, an optimization procedure with two steps was required to identify the parameters of micromechanical model. An acceptable agreement between experimental and numerical results was achieved. Moreover, the influence of texture on the yield strength and the application of the proposed model to the spark plasma sintering processed materials were also discussed. 相似文献
70.
D. T. Pham I. A. Nicholas 《International Journal of Adaptive Control and Signal Processing》2001,15(8):865-881
Low‐temperature desulphurization (LTD) is a low‐cost alternative to conventional wet scrubbing for removing sulphur dioxide from flue gas produced by power generating plants. A problem in the design of conventional controllers to achieve and maintain process conditions for optimal desulphurisation is the lack of mathematical models to characterise the complex desulphurization process and unexpected environ mental disturbances. The aim of the work reported in this paper was to replace a skilled human operator who could successfully regulate the LTD plant through manipulation of low‐level controllers with a competitive neurofuzzy system, which possesses both the learning ability of neural networks and the structural transparency of fuzzy logic systems. A hierarchical control structure was adopted whereby the competitive neurofuzzy method was used at the top level for co‐ordinating actions of low‐level conventional controllers. This approach would considerably simplify the task of designing the control system and has been shown to yield high‐level controllers with performances at least equalling that of expert operators, as demonstrated in this paper. Copyright © 2001 John Wiley & Sons, Ltd. 相似文献