The Clinical Data Intelligence Project

This article is about a new project that combines clinical data intelligence and smart data. It provides an introduction to the “Klinische Datenintelligenz” (KDI) project which is founded by the Federal Ministry for Economic Affairs and Energy (BMWi); we transfer research and development results (R&D) of the analysis of data which are generated in the clinical routine in specific medical domain. We present the project structure and goals, how patient care should be improved, and the joint efforts of data and knowledge engineering, information extraction (from textual and other unstructured data), statistical machine learning, decision support, and their integration into special use cases moving towards individualised medicine. In particular, we describe some details of our medical use cases and cooperation with two major German university hospitals.     

Textile-Based Sensors for Inspection of Composite Materials

The monitoring of mechanical deformation and damage of composite materials is normally performed by established analytical methods,such as strain gauges and opt...     

Freiwilliger Verzicht auf Essen und Trinken – zur ethischen Lagebestimmung eines ambivalenten Begriffs

Ethik in der Medizin - Wie ist der Freiwillige Verzicht auf Essen und Trinken und eine medizinische Begleitung dabei ethisch zu bewerten? Die ethische Bewertung des Freiwilligen Verzichts auf Essen...     

A bibliometric visualization of the economics and sociology of wealth inequality: a world apart?

Scientometrics - Wealth inequality research is fragmented across different social science disciplines. This article explores the potential of interdisciplinary perspectives by investigating the...     

Properties of Laplace Operators for Tetrahedral Meshes

Discrete Laplacians for triangle meshes are a fundamental tool in geometry processing. The so-called cotan Laplacian is widely used since it preserves several important properties of its smooth counterpart. It can be derived from different principles: either considering the piecewise linear nature of the primal elements or associating values to the dual vertices. Both approaches lead to the same operator in the two-dimensional setting. In contrast, for tetrahedral meshes, only the primal construction is reminiscent of the cotan weights, involving dihedral angles. We provide explicit formulas for the lesser-known dual construction. In both cases, the weights can be computed by adding the contributions of individual tetrahedra to an edge. The resulting two different discrete Laplacians for tetrahedral meshes only retain some of the properties of their two-dimensional counterpart. In particular, while both constructions have linear precision, only the primal construction is positive semi-definite and only the dual construction generates positive weights and provides a maximum principle for Delaunay meshes. We perform a range of numerical experiments that highlight the benefits and limitations of the two constructions for different problems and meshes.     

Analysis and refurbishment of damp cellar walls

In the following expertise report, the existing condition of the cellar of a semi‐detached house, which was built in a coupled construction, is analysed and considerations for a hygric refurbishment are discussed. First and foremost, it was necessary to find the cause of the damp present in the outside walls of the cellar of the building. In order to describe the current characteristics of the building, an inventory analysis was made of obvious building defects. This is summarised and described in the following report, which was the basis for all further proceeding. Building physics measurements and evaluations were carried out, building materials were examined for their physical properties and corresponding evaluations and analyses were carried out. Finally, all measurement results and findings were collected to provide a conclusive explanation for the existing defects to the building fabric of the building. This in turn was the foundation for all further measures to be taken in order to determine the necessary remediation concepts and changes to the interior design or the use of the rooms. The aim was to make the cellar space fully usable again and to be able to hand over a list of proposals for the necessary technical remediation measures to the client.     

Lipidated Stapled Peptides Targeting the Acyl Binding Protein UNC119

The acyl-binding UNC119 proteins mediate the activation and transport of various N-myristoylated proteins. In particular, UNC119a plays a crucial role in the completion of cytokinesis. Herein, we report the use of a lipidated peptide originating from the UNC119 binding partner Gnat1 as the basis for the design of lipidated, stabilized α-helical peptides that target UNC119a. By using the hydrocarbon peptide-stapling approach, cell-permeable binders of UNC119a were generated that induced the accumulation of cytokinetic and binucleated cells; this suggests UNC119a as a potential target for the inhibition of cytokinesis.