Philipp Walloch  Christian Hansen  Till Priegann  Prof. Dr. Dennis Schade  Prof. Eric Beitz 《ChemMedChem》2021,16(8):1283-1289

The protozoan parasite Plasmodium falciparum causes the most severe and prevailing form of malaria in sub-Saharan Africa. Previously, we identified the plasmodial lactate transporter, PfFNT, a member of the microbial formate–nitrite transporter family, as a novel antimalarial drug target. With the pentafluoro-3-hydroxy-pent-2-en-1-ones, we discovered PfFNT inhibitors that potently kill P. falciparum parasites in vitro. Four additional human-pathogenic Plasmodium species require attention, that is, P. vivax, most prevalent outside of Africa, and the regional P. malariae, P. ovale and P. knowlesi. Herein, we show that the plasmodial FNT variants are highly similar in terms of protein sequence and functionality. The FNTs from all human-pathogenic plasmodia and the rodent malaria parasite were efficiently inhibited by pentafluoro-3-hydroxy-pent-2-en-1-ones. We further established a phenotypic yeast-based FNT inhibitor screen, and found very low compound cytotoxicity and monocarboxylate transporter 1 off-target activity on human cells, particularly of the most potent FNT inhibitor BH267.meta, allowing these compounds to proceed towards animal model malaria studies.  相似文献   

    

Kepa Zulueta  Alex Arrillaga  Philipp S. Stelzer  Iñaki Martinez 《应用聚合物科学杂志》2021,138(33):50826

Sheet molding compounds (SMC) are ready-to-mold thermoset composite materials reinforced with discontinuous fibers, usually compression molded. Finite element (FE) based compression molding tools can be employed to optimize this process; FE tools require to define material models using raw material data measured through different characterization techniques. In this study, the cure kinetics of an epoxy-based carbon fiber SMC has been characterized by means of differential scanning calorimetry (DSC) and moving die rheometer (MDR) techniques. Based on these datasets, Claxton-Liska and Kamal-Souror models have been set and the compression molding of a validation plate was performed, both experimentally and virtually. The results indicate that, even if both characterization techniques are valid for SMC curing characterization, MDR technique enables the characterization of the material at real molding temperatures and the model based on MDR leads to more accurate results.  相似文献   

    

Jonas Schulz  Philipp Aziz  Hans-Jörg Bart 《化学，工程师，技术》2021,93(7):1080-1087

The fundamental differences in hydrodynamics of the froth and spray regime account for the ongoing interest in search for the point of phase inversion. This short communication presents a new approach for identification of phase inversion on sieve trays in terms of an image-based measurement technique. Image analysis of entrained droplets reveals a distinct increase in Sauter mean diameter and droplet frequency during phase inversion. Further measurement methods like pressure drop, gravimetric analysis of entrained liquid, froth height assessment and photographic observation of the flow regime serve as a reference value and complement the discussion. A flow map based on the experimental data comprises each regime and shows a good agreement with phase inversion correlations from literature.  相似文献   

    

Philipp Weidner  Milad Mehdianpour  Thomas Ummenhofer 《Stahlbau》2016,85(9):620-629

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Philipp Niederhofer  Kathrin Eger  Patrik Schwingenschlgl  Marion Merklein 《国际钢铁研究》2020,91(5)

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Erik Forke  Philipp Niederhofer  Mirko Albrecht  Andr Hüllmann  Verena Krusel  Till Schneiders  Michael Gehde 《国际钢铁研究》2020,91(5)

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Gregory Dardelle  Marlène Jacquemond  Philipp Erni 《Advanced materials (Deerfield Beach, Fla.)》2017,29(23)

Composite polyurea/coacervate core/shell capsules are formed by coupling associative biopolymer phase separation with interfacial polymerization. They combine the excellent chemical stability of synthetic polymer barriers with the strong adhesive properties of protein‐based complex coacervates, inspired by biological underwater glues. To encapsulate volatile oil droplets, a primary coacervate hydrogel capsule is formed by a protein and weak polyanion and is reinforced with a polyurea membrane synthesized in situ at the interface between the coacervate and the oil core. The polyurea layer provides an excellent permeability barrier against diffusion of small volatile molecules while the coacervate portion of the shell enhances adhesion on the targeted substrate.  相似文献   

    

Manuel Schnabel  Mariaconcetta Canino  Kai Schillinger  Philipp Lper  Caterina Summonte  Peter R. Wilshaw  Stefan Janz 《Progress in Photovoltaics: Research and Applications》2016,24(9):1165-1177

Monolithic tandem cells involving a top cell with Si nanocrystals embedded in SiC (Si NC/SiC) and a c‐Si bottom cell have been prepared. Scanning electron microscopy shows that the intended cell architecture is achieved and that it survives the 1100 °C anneal required to form Si NCs. The cells exhibit mean open‐circuit voltages V_oc of 900–950 mV, demonstrating tandem cell functionality, with ≤580 mV arising from the c‐Si bottom cell and ≥320 mV arising from the Si NC/SiC top cell. The cells are successfully connected using a SiC/Si tunnelling recombination junction that results in very little voltage loss. The short‐circuit current densities j_sc are, at 0.8–0.9 mAcm⁻², rather low and found to be limited by current collection in the top cell. However, equivalent circuit simulations demonstrate that in current‐mismatched tandem cells such as the ones studied here, higher j_sc, when accompanied by decreased V_oc, can arise from shunts or breakdown in the limiting cell rather than improved current collection from the limiting cell. This indicates that V_oc is a better optimisation parameter than j_sc for tandem cells where the limiting cell exhibits poor junction characteristics. The high‐temperature‐stable cell architecture developed in this work, coupled with simulations highlighting potential pitfalls in tandem cell analysis, provides a suitable route for optimisation of Si NC layers for photovoltaics on a tandem cell device level. Copyright © 2016 John Wiley & Sons, Ltd.  相似文献   

    

Patricia Zamora  Tanya Georgieva  Inmaculada Salcedo  Nico Elzinga  Philipp Kuntke  Cees JN Buisman 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2017,92(5):1035-1045

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Aline S. Muniz‐Wypych  Mayara M. da Costa  Angelo R. S. Oliveira  Philipp M. Neu  Sigurd Schober  Martin Mittelbach  Luiz P. Ramos  Maria Aparecida F. César‐Oliveira 《European Journal of Lipid Science and Technology》2017,119(11)

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