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91.
Polina P Kuzhir Alesya G Paddubskaya Sergey A Maksimenko Tommi Kaplas Yuri Svirko 《Nanoscale research letters》2013,8(1):60
We analyzed the electromagnetic (EM) shielding effectiveness in the Ka band (26 to 37 GHz) of highly amorphous nanometrically thin pyrolytic carbon (PyC) films with lateral dimensions of 7.2 × 3.4 mm2, which consists of randomly oriented and intertwined graphene flakes with a typical size of a few nanometers. We discovered that the manufactured PyC films, whose thickness is thousand times less than the skin depth of conventional metals, provide a reasonably high EM attenuation. The latter is caused by absorption losses that can be as high as 38% to 20% in the microwave frequency range. Being semi-transparent in visible and infrared spectral ranges and highly conductive at room temperature, PyC films emerge as a promising material for manufacturing ultrathin microwave (e.g., Ka band) filters and shields. 相似文献
92.
Amino‐terminated polylactide micelles with an external poly(ethylene oxide) corona as carriers of drug‐loaded anionic liposomes 下载免费PDF全文
Andrey V Sybachin Polina O Khlynina Vasiliy V Spiridonov Irina G Panova Nikolay S Melik‐Nubarov Alexander A Yaroslavov 《Polymer International》2018,67(10):1352-1358
Micelles were prepared from a mixture of NH2‐terminated poly(l ‐lactide) and poly(d ,l ‐lactide)‐block‐poly(ethylene oxide) (molar ratio of 3:7). The micelles were complexed with bilayer lipid vesicles (liposomes) composed of anionic palmitoyloleoylphosphatidylserine and zwitterionic dioleoylphosphatidylcholine in a molar ratio of 3:7. The micelles and micelle–liposome complexes were characterized using dynamic light scattering, laser electrophoresis, fluorimetry, transmission electron microscopy, enzymatic hydrolysis and cell viability with the following main findings. (i) Average diameter of micelle cores was found to be 70 ± 10 nm. (ii) Each micelle carried ca 20 000 amino groups. (iii) In a pH 7 solution the impact of the protonated NH2 groups in the total surface of micelles was negligible owing to their screening by bulky poly(ethylene oxide) blocks. (iv) The micelles were stable in slightly acidic and neutral aqueous solutions, but aggregated in slightly alkaline solutions. (v) The micelles showed no cytotoxicity up to 0.04 mg mL?1 concentration (the maximum concentration in the experiment). (vi) Each micelle adsorbed ca 30 anionic liposomes loaded with the antitumor antibiotic doxorubicin; the liposomes retained their integrity upon binding with micelles. (vii) The initial micelles and the micelle–liposome complexes showed two‐week stability to enzymatic hydrolysis. © 2018 Society of Chemical Industry 相似文献
93.
E. V. Kalinina N. B. Strokan A. M. Ivanov A. A. Sitnikova A. V. Sadokhin A. Yu. Azarov V. G. Kossov R. R. Yafaev 《Semiconductors》2008,42(1):86-91
Results obtained in a study of spectrometric characteristics of arrays of four detectors based on 4H-SiC ion-implantation-doped p +-n junctions in the temperature range 25–140 °C are reported for the first time. The junctions were fabricated by ion implantation of aluminum into epitaxial 4H-SiC layers of thickness ≤45 μm, grown by chemical vapor deposition with uncompensated donor concentration N d ? N a = (4–6) × 1014 cm?3. The structural features of the ion-implantation-doped p +-layers were studied by secondary-ion mass spectrometry, transmission electron microscopy, and Rutherford backscattering spectroscopy in the channeling mode. Parameters of the diode arrays were determined by testing in air with natural-decay alpha particles with an energy of 3.76 MeV. The previously obtained data for similar single detectors were experimentally confirmed: the basic characteristics of the detector arrays, the charge collection efficiency and energy resolution, are improved as the working temperature increases. 相似文献
94.
A. B. Lysenko O. L. Kosinskaya G. V. Borisova T. V. Kalinina 《The Physics of Metals and Metallography》2012,113(6):588-593
Using a mathematical model of nonequilibrium crystallization of polymorphous metals with a narrow range of stability of the high-temperature modification, we have conducted numerical analysis of the kinetics of the formation of the metastable polytype of cerium (??-Ce) that is fixed by melt quenching at cooling rates more than ??105 K/s. Agreement between the calculation data and the results of X-ray diffraction phase analysis of rapidly quenched foils has been obtained at a physically reasonable value of the model parameter having the meaning of the degree of metastability of ??-Ce. 相似文献
95.
Dena Shahriari Gabriel Loke Ian Tafel Seongjun Park Po‐Han Chiang Yoel Fink Polina Anikeeva 《Advanced materials (Deerfield Beach, Fla.)》2019,31(30)
Microchannel scaffolds accelerate nerve repair by guiding growing neuronal processes across injury sites. Although geometry, materials chemistry, stiffness, and porosity have been shown to influence nerve growth within nerve guidance scaffolds, independent tuning of these properties in a high‐throughput manner remains a challenge. Here, fiber drawing is combined with salt leaching to produce microchannels with tunable cross sections and porosity. This technique is applicable to an array of biochemically inert polymers, and it delivers hundreds of meters of porous microchannel fibers. Employing these fibers as filaments during 3D printing enables the production of microchannel scaffolds with geometries matching those of biological nerves, including branched topographies. Applied to sensory neurons, fiber‐based porous microchannels enhance growth as compared to non‐porous channels with matching materials and geometries. The combinatorial scaffold fabrication approach may advance the studies of neural regeneration and accelerate the development of nerve repair devices. 相似文献
96.
Yulia V. Vakhitova Tatiana S. Kalinina Liana F. Zainullina Anastasiya Yu. Lusta Anna V. Volkova Nikita V. Kudryashov Tatiana A. Gudasheva Alexander A. Shimshirt Ilya A. Kadnikov Mikhail V. Voronin Sergei B. Seredenin 《International journal of molecular sciences》2021,22(24)
Induction of BDNF-TrkB signaling is associated with the action mechanisms of conventional and fast-acting antidepressants. GSB-106, developed as a small dimeric dipeptide mimetic of BDNF, was previously shown to produce antidepressant-like effects in the mouse Porsolt test, tail suspension test, Nomura water wheel test, in the chronic social defeat stress model and in the inflammation-induced model of depression. In the present study, we evaluated the effect of chronic per os administration of GSB-106 to Balb/c mice under unpredictable chronic mild stress (UCMS). It was observed for the first time that long term GSB-106 treatment (1 mg/kg, 26 days) during ongoing UCMS procedure ameliorated the depressive-like behaviors in mice as indicated by the Porsolt test. In addition, chronic per os administration of GSB-106 resulted in an increase in BDNF levels, which were found to be decreased in the prefrontal cortex and hippocampus of mice after UCMS. Furthermore, prolonged GSB-106 treatment was accompanied by an increase in the content of pTrkB706/707 in the prefrontal cortex and by a pronounced increase in the level of pTrkB816 in both studied brain structures of mice subjected to UCMS procedure. In summary, the present data show that chronic GSB-106 treatment produces an antidepressant-like effect in the unpredictable chronic mild stress model, which is likely to be associated with the regulation of the BDNF-TrkB signaling. 相似文献
97.
Anna E. Bugrova Polina A. Strelnikova Maria I. Indeykina Alexey S. Kononikhin Natalia V. Zakharova Alexander G. Brzhozovskiy Evgeny P. Barykin Stanislav I. Pekov Maria S. Gavrish Alexey A. Babaev Anna M. Kosyreva Anna Y. Morozova Daniil A. Degterev Vladimir A. Mitkevich Igor A. Popov Alexander A. Makarov Evgeny N. Nikolaev 《International journal of molecular sciences》2022,23(1)
Alzheimer’s disease (AD) is the leading cause of dementia among the elderly. Neuropathologically, AD is characterized by the deposition of a 39- to 42-amino acid long β-amyloid (Aβ) peptide in the form of senile plaques. Several post-translational modifications (PTMs) in the N-terminal domain have been shown to increase the aggregation and cytotoxicity of Aβ, and specific Aβ proteoforms (e.g., Aβ with isomerized D7 (isoD7-Aβ)) are abundant in the senile plaques of AD patients. Animal models are indispensable tools for the study of disease pathogenesis, as well as preclinical testing. In the presented work, the accumulation dynamics of Aβ proteoforms in the brain of one of the most widely used amyloid-based mouse models (the 5xFAD line) was monitored. Mass spectrometry (MS) approaches, based on ion mobility separation and the characteristic fragment ion formation, were applied. The results indicated a gradual increase in the Aβ fraction of isoD7-Aβ, starting from approximately 8% at 7 months to approximately 30% by 23 months of age. Other specific PTMs, in particular, pyroglutamylation, deamidation, and oxidation, as well as phosphorylation, were also monitored. The results for mice of different ages demonstrated that the accumulation of Aβ proteoforms correlate with the formation of Aβ deposits. Although the mouse model cannot be a complete analogue of the processes occurring in the human brain in AD, and several of the observed parameters differ significantly from human values supposedly due to the limited lifespan of the model animals, this dynamic study provides evidence on at least one of the possible mechanisms that can trigger amyloidosis in AD, i.e., the hypothesis on the relationship between the accumulation of isoD7-Aβ and the progression of AD-like pathology. 相似文献
98.
Iliya Petriev Polina Pushankina Nikita Shostak Mikhail Baryshev 《International journal of molecular sciences》2022,23(1)
A method for obtaining composite gas-diffusion PdCu–Nb–PdCu membranes modified with a nanostructured crystalline coating was developed to increase the performance of Nb-based membranes. A modifying functional layer with a controlled size and composition was synthesized by electrochemical deposition, which made it possible to determine a certain geometric shape for palladium nanocrystallites. Developed PdCu–Nb–PdCu membranes have demonstrated flux values up to 0.232 mmol s−1 m−2 in the processes of diffusion purification of hydrogen at 400 °C. A very significant difference in the hydrogen fluxes through the modified and non-modified composite PdCu–Nb–PdCu membranes reached 1.73 times at the lower threshold temperature of 300 °C. Cu doping of protective layer did not affect the selective properties of the membranes, which was confirmed by the obtained high selectivity values up to 1323, and made it possible to reduce the noble metal content. The research data indicate that the modification of the membrane surface significantly accelerates the hydrogen transfer process at sufficiently low temperatures due to the acceleration of dissociative–associative processes on the surface. The reported approach demonstrates new possibilities for creating productive and cost-efficient membranes based on niobium. 相似文献
99.
Irma Tikanadze Manoni Kurtanidze Marina Rukhadze Ketevan Nanobashvili Polina Toidze George Bezarashvili Ketevan Sigua 《Journal of surfactants and detergents》2020,23(2):339-346
The microenvironment of water droplets of sodium bis (2-ethylhexyl) sulfosuccinate (AOT) and sodium cholate mixed reverse microemulsions was studied. Structural changes of water pockets in mixed reverse micelles were investigated by IR spectroscopy. The O-H stretching vibrational absorption spectra in the region of 3000–3800 cm−1 were fit to three subpeaks with the Monte Carlo method. It was revealed that additives of sodium cholate suppress free water fraction in the water droplets of reverse micelles from 31% to 20% and support rising of bound fraction from 53% to 65%. The binding of optical probe ortho-nitroaniline to the mixed reverse micelles was determined by UV–visible spectroscopy. It was found that introducing of additives of sodium cholate below its critical micelle concentration (CMC) causes increasing of values of binding constant Kb twice compared with reverse micelles modified with pure water. However, values of the binding constant were reduced 4-fold at concentrations of sodium cholate higher than its CMC. Electrical conductivity of the reverse mixed micellar solutions (AOT + sodium cholate) was measured. Water-induced percolation in conductance of mixed reverse microemulsions occurs at a lower value of water/surfactant molar ratio (W) under the influence of sodium cholate, viz. electrical percolation threshold decreases from W = 32 to W = 15. The size of water droplets was estimated with the dynamic light scattering method. It was found that additives of sodium cholate below and higher than the CMC results in increasing and decreasing of hydrodynamic diameters of the water droplets, respectively, but sizes of water droplets decrease at concentrations of sodium cholate higher than its CMC. 相似文献
100.
Polina Lizunkova Elin Engdahl Gbor Borbly Chris Gennings Christian Lindh Carl-Gustaf Bornehag Joëlle Rüegg 《International journal of molecular sciences》2022,23(4)
Endocrine Disrupting Chemicals (EDCs) are man-made compounds that alter functions of the endocrine system. Environmental mixtures of EDCs might have adverse effects on human health, even though their individual concentrations are below regulatory levels of concerns. However, studies identifying and experimentally testing adverse effects of real-life mixtures are scarce. In this study, we aimed at evaluating an epidemiologically identified EDC mixture in an experimental setting to delineate its cellular and epigenetic effects. The mixture was established using data from the Swedish Environmental Longitudinal Mother and child Asthma and allergy (SELMA) study where it was associated with lower birth weight, an early marker for prenatal metabolic programming. This mixture was then tested for its ability to change metabolic programming of human mesenchymal stem cells. In these cells, we assessed if the mixture induced adipogenesis and genome-wide DNA methylation changes. The mixture increased lipid droplet accumulation already at concentrations corresponding to levels measured in the pregnant women of the SELMA study. Furthermore, we identified differentially methylated regions in genes important for adipogenesis and thermogenesis. This study shows that a mixture reflecting human real-life exposure can induce molecular and cellular changes during development that could underlie adverse outcomes. 相似文献