Desalination of brackish water by electrodialysis

The performance of an electrodialysis unit comprising interpolymer type cation and anion-exchange membranes developed in this institute in single-stage and two-stage operation for desalting of brackish waters having different total dissolved solids has been studied highlighting the energy requirement and pressure drop under different conditions. For higher salinity waters, a two-stage reduction is advantageous with lower power requirements and power index. The results will be useful for design and installation of ED plants in brackish water sectors.     

Purinergic Signalling in Allogeneic Haematopoietic Stem Cell Transplantation and Graft-versus-Host Disease

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for blood cancers and other haematological disorders. However, allo-HSCT leads to graft-versus-host disease (GVHD), a severe and often lethal immunological response, in the majority of transplant recipients. Current therapies for GVHD are limited and often reduce the effectiveness of allo-HSCT. Therefore, pro- and anti-inflammatory factors contributing to disease need to be explored in order to identify new treatment targets. Purinergic signalling plays important roles in haematopoiesis, inflammation and immunity, and recent evidence suggests that it can also affect haematopoietic stem cell transplantation and GVHD development. This review provides a detailed assessment of the emerging roles of purinergic receptors, most notably P2X7, P2Y₂ and A_2A receptors, and ectoenzymes, CD39 and CD73, in GVHD.     

Design and Performance Study of Dynamic Fractors in Any of the Four Quadrants

A fractor is a simple fractional-order system. Its transfer function is \(1/Fs^{\alpha }\); the coefficient, F, is called the fractance, and \(\alpha \) is called the exponent of the fractor. This paper presents how a fractor can be realized, using RC ladder circuit, meeting the predefined specifications on both F and \(\alpha \). Besides, commonly reported fractors have \(\alpha \) between 0 and 1. So, their constant phase angles (CPA) are always restricted between \(0^{\circ }\) and \(-90^{\circ }\). This work has employed GIC topology to realize fractors from any of the four quadrants, which means fractors with \(\alpha \) between \(-\)2 and +2. Hence, one can achieve any desired CPA between \(+180^{\circ }\) and \(-180^{\circ }\). The paper also exhibits how these GIC parameters can be used to tune the fractance of emulated fractors in real time, thus realizing dynamic fractors. In this work, a number of fractors are developed as per proposed technique, their impedance characteristics are studied, and fractance values are tuned experimentally.     

Bioadhesive Ranitidine Hydrochloride for Gastroretention with Controlled Microenvironmental pH

Ranitidine hydrochloride is a H₂ receptor blocker used in the treatment of gastric ulcers. Pharmacological factors, in addition to the dosage regimen, favor development of a sustained-release system for ranitidine especially in the therapeutic condition of erosive esophagitis. This investigation delves into the development of bioadhesive type of gastroretentive formulation (tablets) of ranitidine. The effect of mucoadhesive polymers such as Carbopol, hydroxypropyl methyl cellulose, and dextrose were studied. Mucoadhesion, in vitro drug release profile, water uptake, and swelling of the tablet were evaluated. Alkalizing agents were incorporated in an attempt to maintain an alkaline microenvironment within the tablet and improve the stability of the drug in acidic medium. The stability was evaluated using dye test and degradation studies. The drug release profiles were fit into various kinetic models.     

Pulsating flow of a couple stress fluid in a channel with permeable walls

The paper is concerned with an analytical study of the oscillatory flow of a couple stress fluid in a channel, bounded by two permeable walls. The couple stress fluid is considered to be injected into the medium through one of the walls with a given velocity and to be sucked off by the other wall with an equal velocity. The problem is solved by using a perturbation technique. Analytical expressions for the velocity and volumetric flow rate are derived for the oscillatory flow of the couple stress fluid flowing in the channel. By using the method of parametric variation, distribution of the velocity of the couple stress fluid, change in velocity profiles at different instants of time, change in volumetric flow rate with change in frequency and cross-flow Reynolds number are computed, by considering an illustrative example. The study reveals that both the velocity and the volumetric flow rate are quite sensitive to the couple stress parameter, the frequency of oscillation and also to the cross-flow Reynolds number. The study will be immensely useful in resolving different problems associated with oil industries.     

In vitro antioxidant activity of different cultivars of banana flower (Musa paradicicus L.) extracts available in India

Abstract: Six different cultivars of banana flowers (Musa paradicicus) (Kathali, Bichi, Shingapuri, Kacha, Champa, and Kalabou) were analyzed for the content of polyphenol expressed as gallic acid equivalent and flavonoid expressed as quercetein equivalent, and the in vitro total antioxidative activities of the flower extracts were compared with standard and expressed as trolox equivalent. The reducing power, 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) and 2,2‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) radical cation (ABTS?⁺) scavenging activities, inhibition of lipid peroxidation in a linoleic acid emulsion system, and liposome peroxidation system were measured and compared with respective standard antioxidants. Iron‐mediated Fenton reaction was carried out to evaluate the protective effect of the extract of banana flower (Kacha cultivar) against H₂O₂‐induced DNA damage. The Kacha variety contains the maximum amount of polyphenol (11.94 ± 0.03 mg of gallic acid equivalent/g of dry weight) and flavonoid (0.174 ± 0.001 g of quercetin equivalent/g of polyphenol). It also has the highest total antioxidant capacity, DPPH radical scavenging activity, and ABTS?⁺ radical scavenging activity with a least EC₅₀ value of 0.051 mg/mL. Hepatic cell damage in iron‐mediated Fenton reaction caused by free radicals is reduced by the banana flower extract. On the basis of the results obtained, the banana flowers are found to be a potential source of natural antioxidants. This is the first report on the antioxidant properties of the extracts from banana flowers. The study suggests that the flowers of M. paradicicus that are found in India and consumed as vegetable can provide valuable functional ingredients that help in the prevention of oxidative stress.     

Feasibility Study of Virtual Target Scoring Using High‐Speed Imaging Techniques

Measurements of consistency and accuracy are standard techniques to assess the performance of a weapon in case of direct fire kill mechanism. It is often determined from the scoring pattern of a witnessing target erected at a known distance in an open range making use of an in‐line CCD camera with suitable long‐range optics or using an array of acoustic/optical sensors in the close vicinity of the target. In the case of indoor range, acoustic and optical sensors are used to determine the same preferably for small‐caliber ammunitions. However, all these indirect methods are subjected to the constraint of triangulation error. In case of high‐caliber ammunitions, especially fired from tank guns, witnessing targets and acoustics methods are used although it is time‐consuming and labor‐intensive in nature. To overcome these difficulties a virtual scoring method is proposed. Herein, a high‐speed video camera is used for in‐line image acquisition of the projectile at the desired distance using long‐range optics. The virtual target is defined making use of an optical detector placed at the target distance and under the trajectory, where a trigger is generated when the projectile passes over it. This hardware trigger is sent to the high‐speed video camera and then the spatial coordinates of the projectile in the virtual plane is determined off‐line making use of necessary image processing and image analysis. A feasibility study of this technique was performed in a scaled‐down model and laid down in greater details.     

A robust return‐map algorithm for general multisurface plasticity

Three new contributions to the field of multisurface plasticity are presented for general situations with an arbitrary number of nonlinear yield surfaces with hardening or softening. A method for handling linearly dependent flow directions is described. A residual that can be used in a line search is defined. An algorithm that has been implemented and comprehensively tested is discussed in detail. Examples are presented to illustrate the computational cost of various components of the algorithm. The overall result is that a single Newton‐Raphson iteration of the algorithm costs between 1.5 and 2 times that of an elastic calculation. Examples also illustrate the successful convergence of the algorithm in complicated situations. For example, without using the new contributions presented here, the algorithm fails to converge for approximately 50% of the trial stresses for a common geomechanical model of sedementary rocks, while the current algorithm results in complete success. Because it involves no approximations, the algorithm is used to quantify the accuracy of an efficient, pragmatic, but approximate, algorithm used for sedimentary‐rock plasticity in a commercial software package. The main weakness of the algorithm is identified as the difficulty of correctly choosing the set of initially active constraints in the general setting. Copyright © 2016 John Wiley & Sons, Ltd.     

Effect of the nature and amount of dietary energy on lipid composition of rat bone marrow

The effect of the nature and amount of dietary calories on the lipid composition of bone marrow of rats was studied. Male weanling rats were fed 3 isocaloric diets, containing high carbohydrate, normal protein, and high protein, and a fourth high fat diet for 49 days. Feeding of the high carbohydrate, high protein, and high fat diets caused a significant increase in the level of total lipids compared to the normal protein diet. This increase of total lipids was due primarily to the increase in the level of triglycerides. There was no significant difference in fatty acid composition of either nonpolar or polar lipids of bone marrow among rats fed high carbohydrate diet and those fed normal protein diet. A comparison of fatty acid compositions between bone marrow lipids of rats fed high protein diet and the other 2 isocaloric diets revealed that the proportion of palmitic acid was higher and the proportion of oleic acid was lower in animals fed high protein diet than in animals fed the other 2 diets. Compared to the 3 isocaloric low fat diets, dietary feeding of high fat diet caused a decrease in the proportion of palmitic and palmitoleic acids and an increase in the proportion of oleic and linoleic acids in total fatty acids of both nonpolar and polar lipids.