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31.
辐射制备缓释抗癌药阿糖胞苷的研究 总被引:1,自引:0,他引:1
报告了甲基丙烯酸酯类在室温下进行辐射聚合制备缓释抗癌药阿糖胞苷(Ara-C)的研究结果。结果表明,不仅亲水性单体,而且疏水性单体(包括MMA、EMA和BMA等)都可用于辐射固化。加入到亲水性基质中的疏水性单体可以延缓药物的离体释放,其顺序是MMA<EMA<BMA,央MMA-HEMA共聚物中,Ara-C释放率随着基质中的MMA含量增加而降低。药物的离体释放还受许多困素的控制,结果显示:药物释放量随着 相似文献
32.
Arachidonic acid (AA)-induced platelet chemiluminescence (CL) was measured with a lumiphotometer. Quercetin remarkably inhibited the CL, the IC50 of quercetin was 3 mumol.L-1. When quercetin plus aspirin, which inhibits only cyclooxygenase, was added, the inhibitory rate of platelet-CL obviously increased (P < 0.01). On the other hand, the quercetin had a scavenging effect on superoxide anion radical using alkaline sodium dithionite solution generation. The IC50 was 20.9 mumol.L-1. In addition, superoxide dismutase of 0.1 mg.ml-1 inhibited the platelet-CL by 97.8%, while mannitol, a hydroxyl radical scavenger, only by 43.3% at a concentration of 80 mg.ml-1. These results suggest that the mechanism of the inhibiting AA-induced platelet-CL by quercetin was associated with scavenging the superoxide anion radical directly and with inhibiting the cyclooxygenase. 相似文献
33.
Adenomatous polyps are considered as the dominant precursor lesion of colorectal cancer. A phase III colorectal cancer prevention trial, conducted by the Arizona Cancer Center, concerns the ability of wheat bran fibre supplement to reduce the recurrence of adenomatous polyps. All participants in the study are to have had colorectal polyps detected and removed during a baseline (qualifying) colonoscopy within three months prior to enrolment. In this paper, our interest focuses on occurrence of adenomatous polyps at the baseline colonoscopy. We use a truncated Poisson model to fit these types of data. We develop a regression model to assess the effects of explanatory factors on the positive counting variable. We fit truncated Poisson parameters by a log-linear regression model and estimate regression parameters by the maximum likelihood procedure. Finally, we apply it to the baseline colonoscopy data from the Wheat Bran Fiber study. 相似文献
34.
Basic data of four fractions, PM1, PM6, PM7and PM8, derived from Pingshuo bituminous coal were obtained by ultimate analyses, mean molecular weight measure, GC/MS, 13C-NM R, 1H-NM R and FTIR technigues. A method of calculating the average molecular parameters of the fractions is introduced. Based on the calculated parameters, the molecular structure models of the fractions of PM6, PM;and PM8are constructed. Significant structural information about the saturated hydrocarbon and aromatic hydrocarbon with heteroatom groups is given also. 相似文献
35.
本文先将倒虹吸管的管径计算公式整理成等式左边只含管径的一次方法,右边含有管径高阶非线性的迭代函数,然后证明该迭代函数收敛,最后利用数学迭代原理给迭代函数右边赋初值,计算左边的管径。继续迭代下去,就能求出倒虹吸管的管径。 相似文献
36.
报道了以茈为荧光探针,探讨小剂量~(60)Co γ射线照射后小鼠胸腺细胞膜流动性的变化。结果表明,剂量在0.25-1.00Gy范围,胸腺细胞膜流动性降低与剂量之间呈明显线性关系。从0.50Gy起,辐照组荧光强度比值I_1/I_2与I_3/I_2与对照组的比较存有显著差异(P<0.05)。提示淋巴细胞膜流动性的变化可作为小剂量辐照早期效应的敏感指标。 相似文献
37.
38.
An observer-based robust adaptive nonlinear position and speed tracking controller is developed for a permanent magnet synchronous motor with initial rotor angle uncertainty. The unknown initial rotor position is treated as a constant motor parameter in the development of the controller. An incremental encoder, which provides relative position variation of the rotor, is used along with stator current signals to achieve stable control. However, the controller does not require the knowledge of motor parameters and it only assumes friction, external disturbances, and model uncertainties are bounded. By using state observers, the measurement of acceleration and load torque, which is required usually in the nonlinear controller design with high tracking performance, is avoided. The stability of the control system and tracking convergence are guaranteed using Lyapunov theory. Finally, the stability and efficacy of the proposed drive system are verified by experimental results. 相似文献
39.
The growth of Li1+xMn2O4 via detonation reaction was investigated with respect to the presence of an energetic precursor, such as the metallic nitrate and the degree of confinement of the explosive charge. The detonation products were characterized by scanning electron microscopy. Powder X-ray diffraction and transmission electron microscopy were used to characterize the products. Li1+xMn2O4 with 1-2 μm spherical morphology and more uniform secondary particles, but with smaller primary particles of diameters from 20 to 60 nm and a variety of morphologies were found. The oxides produced by this cheap method affirmed the validity of detonation synthesis of nano-size powders. 相似文献
40.