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21.
This paper deals with the weight minimization of planar steel trusses by adopting a differential evolution-based algorithm. Square hollow sections are considered. The design optimization refers to size, shape and topology. The design variables are represented by the geometrical dimensions of the cross sections of the different components of the truss, directly involving the size of the structure, and by some geometrical parameters affecting the outer shape of the truss. The topology is included in the optimization search in a particular way, since the designer at different runs of the algorithm can change the number of bays keeping constant the total length of the truss, to successively choose the best optimal solution. The minimum weight optimum design is posed as a single-objective optimization problem subject to constraints formulated in accordance with the current Eurocode 3. The optimal solution is obtained by a Differential Evolutionary (DE) algorithm. In the DE algorithm, a particular combination of mutation and crossover operators is adopted in order to achieve the best solutions and a specific way for dealing with constraints is introduced. The effectiveness of the proposed approach is shown with reference to two case-studies. The analysis results prove the versatility of the optimizer algorithm with regard to the three optimization categories of sizing, shape, topology as well as its high computational performances and its efficacy for practical applications. In particular useful practical indications concerning the geometrical dimensions of the various involved structural elements can be deduced by the optimal solutions: in a truss girder the cross section of the top chord should be bigger than the one of the bottom chord as well as diagonals should be characterized by smaller cross sections with respect to the top and bottom chords in order to simultaneously optimize the weight and ensure an optimal structural behaviour.  相似文献   
22.
23.

Objective

Current magnetic resonance imaging (MRI) axon diameter measurements rely on the pulsed gradient spin-echo sequence, which is unable to provide diffusion times short enough to measure small axon diameters. This study combines the AxCaliber axon diameter fitting method with data generated from Monte Carlo simulations of oscillating gradient spin-echo sequences (OGSE) to infer micron-sized axon diameters, in order to determine the feasibility of using MRI to infer smaller axon diameters in brain tissue.

Materials and methods

Monte Carlo computer simulation data were synthesized from tissue geometries of cylinders of different diameters using a range of gradient frequencies in the cosine OGSE sequence . Data were fitted to the AxCaliber method modified to allow the new pulse sequence. Intra- and extra-axonal water were studied separately and together.

Results

The simulations revealed the extra-axonal model to be problematic. Rather than change the model, we found that restricting the range of gradient frequencies such that the measured apparent diffusion coefficient was constant over that range resulted in more accurate fitted diameters. Thus a careful selection of frequency ranges is needed for the AxCaliber method to correctly model extra-axonal water, or adaptations to the method are needed. This restriction helped reduce the necessary gradient strengths for measurements that could be performed with parameters feasible for a Bruker BG6 gradient set. For these experiments, the simulations inferred diameters as small as 0.5 μm on square-packed and randomly packed cylinders. The accuracy of the inferred diameters was found to be dependent on the signal-to-noise ratio (SNR), with smaller diameters more affected by noise, although all diameter distributions were distinguishable from one another for all SNRs tested.

Conclusion

The results of this study indicate the feasibility of using MRI with OGSE on preclinical scanners to infer small axon diameters.
  相似文献   
24.

Objective

Simultaneous modeling of true 2-D spectroscopy data, or more generally, interrelated spectral datasets has been described previously and is useful for quantitative magnetic resonance spectroscopy applications. In this study, a combined method of reference-lineshape enhanced model fitting and two-dimensional prior-knowledge fitting for the case of diffusion weighted MR spectroscopy is presented.

Materials and methods

Time-dependent field distortions determined from a water reference are applied to the spectral bases used in linear-combination modeling of interrelated spectra. This was implemented together with a simultaneous spectral and diffusion model fitting in the previously described Fitting Tool for Arrays of Interrelated Datasets (FiTAID), where prior knowledge conditions and restraints can be enforced in two dimensions.

Results

The benefit in terms of increased accuracy and precision of parameters is illustrated with examples from Monte Carlo simulations, in vitro and in vivo human brain scans for one- and two-dimensional datasets from 2-D separation, inversion recovery and diffusion-weighted spectroscopy (DWS). For DWS, it was found that acquisitions could be substantially shortened.

Conclusion

It is shown that inclusion of a measured lineshape into modeling of interrelated MR spectra is beneficial and can be combined also with simultaneous spectral and diffusion modeling.
  相似文献   
25.
26.
胡硕  周寒宇 《中外建筑》2013,(11):80-81
本文通过对儿童游乐场景观要素的分析,结合国内外优秀案例,针对如何优化儿童游乐场所的空间环境质量、如何增强游乐场所趣味性等问题,进行了初步的研究分析,对创造优质的儿童游乐场有一定的指导意义。  相似文献   
27.
文章根据生态旅游型的综合项目规划的内容目标,结合博望城一九龙半岛板块规划项目,在项目规划设计中引入树生之脉设计理念,因地势、顺地形,力图探索打造一个山水灵动的都市乐园、清雅寄合的怡养居所。  相似文献   
28.
从技术与设计结合这一老话题出发,介绍高年级设计课的有关专题实践。这一课题将技术集成作为目标指向,围绕装配技术和节能设计两个核心,双轨并行,具有多节点的整体构架。为了让学生中观深度、综合性把握多种建筑技术,强调手法化、构件化、体系化、集成化和可视化的设计要求。  相似文献   
29.
在当下电子信息迅猛发展的时代,信息技术已经逐渐成为了人们生活当中不可或缺的一个重要部分,同时也影响着人们的生存观念和生活方式,进而对建筑的设计也产生了不小的影响和冲击。以日本建筑师伊东丰雄获得普利茨克奖为契机,在对伊东丰雄以往作品进行回顾和探讨的同时,从大家所熟悉的空间流动性为线索来解析在伊东丰雄的建筑中所包含的不同寻常的特质以及这种特质的转变。通过对建筑流动性转变的浅析,再次解读伊东在对于建筑创作的过程当中与同僚的不同之处。  相似文献   
30.
Zhu  Xuefang  He  Meng  Xiao  Ling  Liu  Haozhuo  Hu  Mancheng  Li  Shuni  Zhai  Quanguo  Chen  Yu  Jiang  Yucheng 《Journal of Applied Electrochemistry》2022,52(6):979-987
Journal of Applied Electrochemistry - A novel nitrite electrochemical biosensor is constructed by glassy carbon electrodes (GC) coated by chloroperoxidase (CPO) -Au nanoparticles-MoS2 nanoflowers...  相似文献   
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